Environmental and Molecular Mutagenesis This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A longitudinal study of atrazine and 2,4 ‐D exposure and oxidative stress markers among iowa corn farmers
Reactive oxygen species, potentially formed through environmental exposures, can overwhelm an organism's antioxidant capabilities resulting in oxidative stress. Long‐term oxidative stress is linked with chronic diseases. Pesticide exposures have been shown to cause oxidative stress in vivo. We utilized a longitudinal study of corn farmers and non‐farming controls in Iowa to examine the impact of exposure to the widely used herbicides atrazine and 2,4‐dichlorophenoxyacetic acid (2,4‐D) on markers of oxidative stress. 225 urine samples were collected during five agricultural time periods (pre‐planting, planting, gr...
Source: Environmental and Molecular Mutagenesis - January 23, 2017 Category: Molecular Biology Authors: Catherine C. Lerro, Laura E. Beane Freeman, L ützen Portengen, Daehee Kang, Kyoungho Lee, Aaron Blair, Charles F. Lynch, Berit Bakke, Anneclaire J. De Roos, Roel C.H. Vermeulen Tags: Research Article Source Type: research

Issue Information
(Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - January 23, 2017 Category: Molecular Biology Tags: Issue Information Source Type: research

Developmental programming: Interaction between prenatal BPA and postnatal overfeeding on cardiac tissue gene expression in female sheep
Epidemiologic studies and studies in rodents point to potential risks from developmental exposure to BPA on cardiometabolic diseases. Furthermore, it is becoming increasingly evident that the manifestation and severity of adverse outcomes is the result of interaction between developmental insults and the prevailing environment. Consistent with this premise, recent studies in sheep found prenatal BPA treatment prevented the adverse effects of postnatal obesity in inducing hypertension. The gene networks underlying these complex interactions are not known. mRNA‐seq of myocardium was performed on four groups of four female ...
Source: Environmental and Molecular Mutagenesis - January 11, 2017 Category: Molecular Biology Authors: L.A. Koneva, A.K. Vyas, R.C. McEachin, M. Puttabyatappa, H. ‐S. Wang, M.A. Sartor, V. Padmanabhan Tags: Research Article Source Type: research

In vitro responses to known in vivo genotoxic agents in mouse germ cells
Genotoxic compounds have induced DNA damage in male germ cells and have been associated with adverse clinical outcomes including enhanced risks for maternal, paternal and offspring health. DNA strand breaks represent a great threat to the genomic integrity of germ cells. Such integrity is essential to maintain spermatogenesis and prevent reproduction failure. The Comet assay results revealed that the incubation of isolated germ cells with n‐ethyl‐n‐nitrosourea (ENU), 6‐mercaptopurine (6‐MP) and methyl methanesulphonate (MMS) led to increase in length of Olive tail moment and % tail DNA when compared with the untr...
Source: Environmental and Molecular Mutagenesis - December 31, 2016 Category: Molecular Biology Authors: Khaled Habas, Martin H. Brinkworth, Diana Anderson Tags: Research Article Source Type: research

Contribution of ATM and ATR kinase pathways to p53 ‐mediated response in etoposide and methyl methanesulfonate induced DNA damage
This study evaluated chemical specificity of the p53 pathway response by manipulating p53 or its upstream kinases and assessing the effect on DNA damage and cellular responses to prototype chemicals: etoposide (ETP, topoisomerase II inhibitor) and methyl methane sulfonate (MMS, alkylating agent). p53‐deficient cells demonstrated reduced accumulation of the p53 target proteins MDM2, p21, and Wip1; reduced apoptotic response; and increased DNA damage (p‐H2AX and micronuclei) with both chemicals. However, p53 was not essential for cell cycle arrest in HT1080 or HCT116 cells. The two chemicals induced different patterns of...
Source: Environmental and Molecular Mutagenesis - December 31, 2016 Category: Molecular Biology Authors: Bin Sun, Susan M. Ross, Sean Rowley, Yeyejide Adeleye, Rebecca A. Clewell Tags: Research Article Source Type: research

Tumor ‐associated APE1 variant exhibits reduced complementation efficiency but does not promote cancer cell phenotypes
We report herein that the tumor‐associated APE1 variant, R237C, shows reduced complementation efficiency of the methyl methanesulfonate hypersensitivity and impaired cell growth exhibited by APE1‐deficient mouse embryonic fibroblasts. Overexpression of wild‐type APE1 or the R237C variant in the nontransformed C127I mouse cell line had no effect on proliferation, cell cycle status, steady‐state DNA damage levels, mitochondrial function, or cellular transformation. A human cell line heterozygous for an APE1 knockout allele had lower levels of endogenous APE1, increased cellular sensitivity to DNA‐damaging agents, i...
Source: Environmental and Molecular Mutagenesis - December 31, 2016 Category: Molecular Biology Authors: Jennifer L. Illuzzi, Daniel R. McNeill, Paul Bastian, Boris Brenerman, Robert Wersto, Helen R. Russell, Fred Bunz, Peter J. McKinnon, Kevin G. Becker, David M. Wilson Tags: Research Article Source Type: research

Copper oxide nanoparticles and copper sulphate act as antigenotoxic agents in drosophila melanogaster
The biological reactivity of metal and metal oxide nanomaterials is attributed to their redox properties, which would explain their pro‐ or anti‐cancer properties depending on exposure circumstances. In this sense, copper oxide nanoparticles (CuONP) have been proposed as a potential anti‐tumoral agent. The aim of this study was to assess if CuONP can exert antigenotoxic effects using Drosophila melanogaster as an in vivo model. Genotoxicity was induced by two well‐known genotoxic compounds, namely potassium dichromate (PD) and ethyl methanesulfonate (EMS). The wing‐spot assay and the comet assay were used as biom...
Source: Environmental and Molecular Mutagenesis - November 30, 2016 Category: Molecular Biology Authors: Mohamed Alaraby, Alba Hern ández, Ricard Marcos Tags: Research Article Source Type: research

High pesticide exposure events and DNA methylation among pesticide applicators in the agricultural health study
Pesticide exposure has been associated with acute and chronic adverse health effects. DNA methylation (DNAm) may mediate these effects. We evaluated the association between experiencing unusually high pesticide exposure events (HPEEs) and DNAm among pesticide applicators in the Agricultural Health Study (AHS), a prospective study of applicators from Iowa and North Carolina. DNA was extracted from whole blood from male AHS pesticide applicators (n = 695). Questionnaire data were used to ascertain the occurrence of HPEEs over the participant's lifetime. Pyrosequencing was used to quantify DNAm in CDH1, GSTp1, and MGMT pr...
Source: Environmental and Molecular Mutagenesis - November 30, 2016 Category: Molecular Biology Authors: Jennifer A. Rusiecki, Laura E. Beane Freeman, Matthew R. Bonner, Melannie Alexander, Ligong Chen, Gabriella Andreotti, Kathryn H. Barry, Lee E. Moore, Hyang ‐Min Byun, Freya Kamel, Michael Alavanja, Jane A. Hoppin, Andrea Baccarelli Tags: Research Article Source Type: research

Issue Information
(Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - November 20, 2016 Category: Molecular Biology Tags: Issue Information Source Type: research

Cover Image
(Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - November 20, 2016 Category: Molecular Biology Tags: Cover Image Source Type: research

DNA methylation changes in Mexican children exposed to arsenic from two historic mining areas in San Luis potos í
In this study, we examined the methylation status of Alu and long interspersed nucleotide elements (LINE‐1) and their association with levels of urinary arsenic in 84 Mexican children between 6 and 12 years old from two historic mining areas in the State of San Luis Potosí, Mexico. Urinary arsenic levels were determined by atomic absorption spectrophotometry and DNA methylation analysis was performed in peripheral blood leukocytes by bisulfite‐pyrosequencing. The geometric mean of urinary arsenic was 26.44 µg/g Cr (range 1.93–139.35). No significant differences in urinary arsenic or methylation patterns due to gend...
Source: Environmental and Molecular Mutagenesis - November 8, 2016 Category: Molecular Biology Authors: Jorge Alejandro Alegr ía‐Torres, Leticia Carrizales‐Yánez, Fernando Díaz‐Barriga, Fernando Rosso‐Camacho, Valeria Motta, Letizia Tarantini, Valentina Bollati Tags: Research Article Source Type: research

Mutations in apoptotic genes and micronucleus occurrence in vinyl chloride ‐exposed workers in China
Conclusion: Genetic polymorphisms in genes related to apoptosis process may have an impact on chromosomal damage induced by vinyl chloride. Environ. Mol. Mutagen., 2016. © 2016 Wiley Periodicals, Inc. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - October 31, 2016 Category: Molecular Biology Authors: Nannan Feng, Guoqiao Zheng, Yanhui Hao, Yong Li, Yandan Xu, Xiaowen Xu, Guanghui Zhang, Jinwei Wang, Yongliang Li, Paul Brandt ‐Rauf, Zhao‐lin Xia Tags: Research Article Source Type: research

Issue Information
(Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - October 13, 2016 Category: Molecular Biology Tags: Issue Information Source Type: research

Cover Image
(Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - October 13, 2016 Category: Molecular Biology Tags: Cover Image Source Type: research

The micro ‐Ames test: A direct comparison of the performance and sensitivities of the standard and 24‐well plate versions of the bacterial mutation test
We describe methods and results used in direct comparisons of the sensitivity of micro and standard systems using the same cultures, formulations, etc. Initial testing utilized the plate incorporation method and, later, the pre‐incubation method. In a subsequent phase of testing, a four‐way direct comparison was made between the pre‐incubation and plate incorporation methods in both systems using some direct‐acting mutagens. Tests used only those strain/S9/chemical combinations where a response was expected. Historical control results accumulated during testing are also presented. Spontaneous and induced revertant ...
Source: Environmental and Molecular Mutagenesis - September 30, 2016 Category: Molecular Biology Authors: Raymond Proudlock, Kristie Evans Tags: Research Article Source Type: research