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Toxicological characterization of ZnO nanoparticles in malignant and non ‐malignant cells
This study was designed to systematically investigate cytotoxicity, apoptosis, cell cycle alterations, and genotoxicity induced by ZnO‐NP. Moreover, it was an aim of the investigations to specify the diverse effects of nanoparticle exposure in malignant in comparison with non‐malignant cells. Therefore, human head and neck squamous cell carcinoma‐derived FaDu cells were incubated with 4–20 µg/ml of ZnO‐NPs for 1–48 hr and tested for cell viability, cell cycle alterations, apoptosis and caspase‐3 gene expression as a sensitive marker of molecular apoptotic processes with regard to time‐ and dose‐depende...
Source: Environmental and Molecular Mutagenesis - November 18, 2017 Category: Molecular Biology Authors: Helena Moratin, Agmal Scherzad, Thomas Gehrke, Pascal Ickrath, Katrin Radeloff, Norbert Kleinsasser, Stephan Hackenberg Tags: Research Article Source Type: research

Genotoxicity of 11 heavy metals detected as food contaminants in two human cell lines
Environmental and Molecular Mutagenesis,Volume 59, Issue 3, Page 202-210, April 2018. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - November 18, 2017 Category: Molecular Biology Source Type: research

Toxicological characterization of ZnO nanoparticles in malignant and non ‐malignant cells
Environmental and Molecular Mutagenesis,Volume 59, Issue 3, Page 247-259, April 2018. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - November 18, 2017 Category: Molecular Biology Source Type: research

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Environmental and Molecular Mutagenesis,Volume 59, Issue 3, Page 202-210, April 2018. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - November 18, 2017 Category: Molecular Biology Source Type: research

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Environmental and Molecular Mutagenesis,Volume 59, Issue 3, Page 247-259, April 2018. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - November 18, 2017 Category: Molecular Biology Source Type: research

Genotoxicity of 11 heavy metals detected as food contaminants in two human cell lines
In this study, the genotoxic and cytotoxic properties of 15 different oxidation statuses of 11 different heavy metals were investigated using high‐throughput screening (γH2AX assay) in two human cell lines (HepG2 and LS‐174T) representative of target organs (liver and colon) for food contaminants. Base on their lowest observed adverse effect concentration, the genotoxic potency of each heavy metal in each cell line was ranked in decreasing order, NaAsO2 > CdCl2 > PbCl2 (only in LS‐174T cells) > As2O5 > SbCl3 > K2TeO3 > As2O3. No significant genotoxicity was observed with the...
Source: Environmental and Molecular Mutagenesis - November 18, 2017 Category: Molecular Biology Authors: B. Kopp, D. Zalko, M. Audebert Tags: Research Article Source Type: research

Issue Information
(Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - November 14, 2017 Category: Molecular Biology Tags: Issue Information Source Type: research

Prenatal diethylstilbestrol exposure and cancer risk in women
Environmental and Molecular Mutagenesis, EarlyView. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - November 10, 2017 Category: Molecular Biology Source Type: research

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Environmental and Molecular Mutagenesis, Ahead of Print. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - November 10, 2017 Category: Molecular Biology Source Type: research

Oxidative stress and inflammation mediate the effect of air pollution on cardio ‐ and cerebrovascular disease: A prospective study in nonsmokers
Environmental and Molecular Mutagenesis,Volume 59, Issue 3, Page 234-246, April 2018. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - November 8, 2017 Category: Molecular Biology Source Type: research

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Environmental and Molecular Mutagenesis,Volume 59, Issue 3, Page 234-246, April 2018. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - November 8, 2017 Category: Molecular Biology Source Type: research

Glycosylphosphatidylinositol (GPI) anchored protein deficiency serves as a reliable reporter of Pig ‐a gene Mutation: Support from an in vitro assay based on L5178Y/Tk+/− cells and the CD90.2 antigen
Lack of cell surface glycosylphosphatidylinositol (GPI)‐anchored protein(s) has been used as a reporter of Pig‐a gene mutation in several model systems. As an extension of this work, our laboratory initiated development of an in vitro mutation assay based on the flow cytometric assessment of CD90.2 expression on the cell surface of the mouse lymphoma cell line L5178Y/Tk+/−. Cells were exposed to mutagenic and nonmutagenic compounds for 24 hr followed by washout and incubation for an additional 7 days. Following this mutant manifestation time, cells were labeled with fluorescent antibodies against CD90.2 and CD45 anti...
Source: Environmental and Molecular Mutagenesis - November 8, 2017 Category: Molecular Biology Authors: Jeffrey C. Bemis, Svetlana L. Avlasevich, Carson Labash, Page McKinzie, Javier Revollo, Vasily N. Dobrovolsky, Stephen D. Dertinger Tags: Research Article Source Type: research

A regenerative erythropoietic response does not increase the frequency of Pig ‐a mutant reticulocytes and erythrocytes in Sprague‐Dawley rats
The in vivo rodent Pig‐a mutation assay is a sensitive test to identify exposure to mutagenic substances, and has been proposed as an assay for the identification of impurities for pharmaceuticals. Red blood cells (RBCs) and reticulocytes (RETs) are analyzed by flow cytometry after exposure to potentially mutagenic chemicals for cells deficient in the cell surface anchored protein CD59, representing mutation in the X‐linked Pig‐a gene. The full potential of the assay as well as its limitations are currently being explored. The current study investigated the effects of regenerative erythropoietic bone marrow responses...
Source: Environmental and Molecular Mutagenesis - October 27, 2017 Category: Molecular Biology Authors: John Nicolette, Joel Murray, Paul Sonders, Bruce Leroy Tags: Brief Communication Source Type: research

Limited ability of DNA polymerase kappa to suppress benzo[a]pyrene ‐induced genotoxicity in vivo
In this study, we examined genotoxicity of benzo[a]pyrene (BP) to determine whether Polk actually suppressed BP‐induced genotoxicity as predicted by biochemistry and in vitro cell culture studies. Seven‐week‐old inactivated Polk KI and wild‐type (WT) mice were treated with BP at doses of 5, 15, or 50 mg/(kg·day) for three consecutive days by intragastric gavage, and mutations in the colon and micronucleus formation in the peripheral blood were examined. Surprisingly, no differences were observed in the frequencies of mutations and micronucleus formation at 5 or 50 mg/kg doses. Inactivated Polk KI mice exhibited ap...
Source: Environmental and Molecular Mutagenesis - October 27, 2017 Category: Molecular Biology Authors: Kenichi Masumura, Naomi Toyoda ‐Hokaiwado, Naoko Niimi, Petr Grúz, Naoko A. Wada, Akira Takeiri, Kou‐ichi Jishage, Masayuki Mishima, Takehiko Nohmi Tags: Research Article Source Type: research

Issue Information
(Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - October 16, 2017 Category: Molecular Biology Tags: Issue Information Source Type: research