Anti-angiogenic Treatment in Metastatic Colorectal Cancer: Current Issues and Future Aims
We describe the principal mechanisms of resistance to anti-VEGF therapy and discuss potential biomarkers to be investigated in the near future. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research
Immunology Behind Tumors: A Mini Review
Conclusion: This review is focused not only on the mechanism by which the immune system protects us but also on the ways in which it can inflict the body and how to modulate it with therapy. Thus, understanding the interaction of a tumor with the immune system provides insights into mechanisms that can be utilized to elicit anti-tumor immune responses. Here, we have recapitulated the function of the tumor microenvironment and immune checkpoints. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research
Meet our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research
A Connecting Switch Among Aging, Diabetes and Tumor: Avenue Leading to Cancer Therapeutics
In recent, curiosity is at the forefront to understand the complexity of cancer driven by genetic, molecular and epigenetic programming due to life style, environmental pressure and metabolite adaptations. On the other hand, complex and heterogeneous nature of cancer is linked to the metabolic and molecular landscape of diabetic complications. This Letter to editor connects the dots and highlights the need to view cancer beyond the mirror of genetic and epigenetic aberration as metabolic disturbances. In this commentary, the author highlights the major contributions from two elegant papers from Cha et al. (2018) and Wu et ...
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research
Chitosan Nanoparticles as a Carrier for Indigofera intricata Plant Extract: Preparation, Characterization and Anticancer Activity
Conclusion: Our results revealed that traditional medicinal plants could be an excellent source of natural anticancer agents and the chitosan-extract nanoparticles is a promising formulation strategy to enhance their clinical effectiveness. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research
Serotonin (5HTR2A and 5HTR3A) and GABA (GABAB) Receptor Genes Overexpression are Correlated with Non-small Cell Lung Cancer (NSCLC)
Conclusion: According to our findings, 5-HT and GABA may be involved in the regulation of tumorigenesis via their receptors, thus playing an important role in lung cancer. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research
Possible Considerations for the Management of Turcot’s Syndrome?
Conclusion: TS is a disease that affects mostly members of families with multiple genetic mutations and types of cancers. And because of the unknown mechanisms of inheritance, it is useful to establish guidelines for the approach of those patients, in order to minimize the high mortality rate. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research
Statins: A Conceivable Remedial Role for the Regulation of Cancer Progression
The mevalonate pathway (also known as the cholesterol biosynthesis pathway) plays a crucial metabolic role in normal cell function as well as in the pathological environment. It leads to the synthesis of sterol and non-sterol isoprenoid biomolecules which subserve a variety of cellular functions. It is known to be deregulated in many disease processes. Statins and bisphosphonates are prominent inhibitors of the mevalonate pathway. They inhibit cell proliferation and activate apoptotic signalling and suppress tumour growth. Statins subdue metastatic spread of tumours by virtue of their ability to suppress invasion and angio...
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research
A Review on Important Histone Acetyltransferase (HAT) Enzymes as Targets for Cancer Therapy
In this study, we have reviewed the important roles of HATs in different human malignancies. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research
Beyond PD-1/PD-L1 Axis Blockade: New Combination Strategies in Metastatic Melanoma Treatment
Metastatic melanoma treatment has dramatically changed in the last few years, having a breakthrough with the introduction of targeted agents and immunotherapy. PD-1/PD-L1 pathway is one of the physiologic mechanisms of peripheral immune tolerance, but it also represents a mechanism of tumor immune escape. PD-1/PD-L1 inhibitors represent new immune-checkpoint drugs currently used in metastatic melanoma treatment. Resistance to PD-1/PD-L1 axis blockade, which is the main cause of therapeutic failure during therapeutic use of these drugs, could be linked to several mechanism of immune escape. In fact, other inhibitory recepto...
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research
Implementing Cancer Exercise Rehabilitation: An Update on Recommendations for Clinical Practice
A growing body of research evidence supports the benefit of exercise for cancer survivors both during and after cancer treatment. The purpose of this paper is to provide an update on our previously published review in 2006 on the state of the evidence supporting exercise for survivors of cancer as well as guidelines for integrating exercise programming in the cancer clinical setting. First, we provide a brief overview on the benefits of exercise as well as preliminary evidence supporting the implementation of community-based exercise programs. Second, we summarize the principles and goals of exercise, and the identified ba...
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research
Systemic Therapies for Metastatic Testicular Germ Cell Tumors: Past, Present and Future
Testicular germ cell tumors (TGCTs) are unique to that of most other solid tumors because they are highly curable in the metastatic setting. While the use of cisplatin-based chemotherapy continues to drive cure in this patient population, important improvements in the delivery of therapy, creation of risk-adjusted treatment paradigms, and salvage-therapy options have further enhanced survival as well. The future holds promise for a more multidisciplinary approach to care, through advancements in biochemical markers and a better understanding of how surgical and radiotherapy approaches can integrate into our existing manage...
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research
Meet our Associate Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - July 11, 2019 Category: Cancer & Oncology Source Type: research
Review of Patent Series eBook "Topics in Anti-Cancer Research, Volume 6, 2017"
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 22, 2019 Category: Cancer & Oncology Source Type: research
Purification and Characterization of a Protease Inhibitor with Anticancer Potential from Bacillus endophyticus JUPR15
Conclusion: The isolate exhibited promising anticancer activity on in-vitro Hela and HepG2 cancer cell lines, showing its application potentials. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 22, 2019 Category: Cancer & Oncology Source Type: research
