The Role of Bacterial Superantigens in the Immune Response: From Biology to Cancer Treatment
Conclusion: Superantigens induce the proliferation of T lymphocytes and antigen-presenting cells by binding to MHCII molecules and V beta regions in T cell receptors. Therefore, the presentation of tumor cell antigens is increased. Additionally, the production of important cytokines by T cells and APCs contributes to the stimulation of immune response against tumor cells. The manipulation of bacterial vector systems through incorporating genesrelated to SAgs and other immune response factors is a good strategy for the immune system stimulating and eradicating tumor cells along with other immunotherapy agents. (Source: Curr...
Source: Current Cancer Therapy Reviews - April 5, 2021 Category: Cancer & Oncology Source Type: research
Carbohydrate-functionalized Liposomes in Cancer Therapy
Existing cancer treatments are often accompanied by adverse side effects that can greatly reduce the quality of life of cancer patients; this sets the platform for the development and application of nanocarrier-based platforms for the delivery of anticancer drugs. Among these nanocarriers, liposomes have demonstrated excellent potential in drug delivery applications. Furthermore, the overexpression of certain receptors on cancer cells has led to the development of active targeting approaches where liposome surfaces are decorated with ligands against these receptors. Given the central role that sugars play in cancer biology...
Source: Current Cancer Therapy Reviews - April 5, 2021 Category: Cancer & Oncology Source Type: research
Meet Our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - April 5, 2021 Category: Cancer & Oncology Source Type: research
Preface
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - April 5, 2021 Category: Cancer & Oncology Source Type: research
Acknowledgements to Reviewers
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research
Titanium Oxide Nanoparticles Improve the Chemotherapeutic Action of Erlotinib in Liver Cancer Cells
Conclusion: Our data showed that loading ERL on TiO2NPs was more efficient than AuNPs. However, both nanocarriers were efficient compared with control. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research
Association of CA 15-3 and CEA with Liver Metastases in Patients with Breast Cancer
Conclusion: The increase in the levels of CEA and ALP can be diagnostic markers for liver metastases from breast cancer. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research
Drug Delivery Approaches for Doxorubicin in the Management of Cancers
Conclusion: In the review, we described the significance of DOX in the form of different delivery approaches in the management of cancers with a reduction in the associated toxicity. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research
Immunoliposomes: Synthesis, Structure, and their Potential as Drug Delivery Carriers
Immunoliposomes have emerged as attractive drug targeting vehicles for cancer treatment. This review presents the recent advances in the design of immunoliposomes encapsulating a variety of chemotherapeutic agents. We provided an overview of different routes that can be used to conjugate antibodies to the surfaces of liposomes, as well as several examples of stimuliresponsive immunoliposome systems and their therapeutic potential for cancer treatment. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research
The Important Role of Oncolytic Viruses in Common Cancer Treatments
Oncolytic viruses (OV) are considered as promising tools in cancer treatment. In addition to direct cytolysis, the stimulation of both innate and adaptive immune responses is the most important mechanism in oncolytic virotherapy that finally leads to the long-standing tumor retardations in the advanced melanoma clinical trials. The OVs have become a worthy method in cancer treatment, due to their several biological advantages including (1) the selective replication in cancer cells without affecting normal cells; (2) the lack of resistance to the treatment; (3) cancer stem cell targeting; (4) the ability to be spread; and (...
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research
Hepatoblastoma: Review of Pathology, Diagnosis and Modern Treatment Strategies
Hepatoblastoma (HB) is the most common primary malignant hepatic tumor of childhood and, occurring predominantly in the first two years of life. Approximately 100 cases are diagnosed every year in the United States of America. The management of HB has changed markedly over the last three decades. Alfa feto protein (AFP) and beta human chorionic gonadotrophin (beta HCG) are the main tumor markers and are markers for diagnosis and follow up. International collaborative efforts have led to the implementation of the Pre - Treatment Extent of the Disease PRETEXT staging system consensus classification to assess upfront resectab...
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research
MiR-492 as an Important Biomarker for Early Diagnosis and Targeted Treatment in Different Cancers
Recent studies have led to a more detailed understanding of the roles played by microRNAs in health and disease, and their potential use as biomarkers in physiological and pathophysiological processes involving cancer initiation and progression. MiR-492 is encoded by a pseudogene, has a key role in some human cancer cells and its overexpression in tissues, and it has been proposed that it can be used as a good biomarker for management and early diagnosis of some cancers including breast cancer, colorectal and ovarian cancer, hepatocellular cancer, retinoblastoma and pancreatic cancer. The aim of this review was to summariz...
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research
Exploring Nanoemulsion for Liver Cancer Therapy
Cancer is a leading cause of mortality worldwide, accounting for 8.8 million deaths in 2015. Among these, at least 0.78 million people died of liver cancer alone. The recognized risk factors for liver cancer include chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, exposure to dietary aflatoxin, fatty liver disease, alcohol-induced cirrhosis, obesity, smoking, diabetes, and iron overload. The treatment plan for early diagnosed patients includes radiation therapy, tumour ablation, surgery, immunotherapy, and chemotherapy. Some sort of drug delivery vehicles has to be used when the treatment plan is targ...
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research
Meet our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 20, 2020 Category: Cancer & Oncology Source Type: research
Vagaries of the Host Response in the Development of Hepatitis B-related Hepatocellular Carcinoma: A Case Series
The hepatitis B virus (HBV) is one of the leading causes of hepatocellular carcinoma (HCC) worldwide. In the endemic region, the infection is commonly spread through vertical transmission in which mother and child possess genetically identical viral genotypes in the setting of similar host genomes. Despite these genetic similarities, clinical outcomes from chronic hepatitis B (CHB) can vary widely, ranging from lifelong asymptomatic infection to terminal HCC. Presented here are the longitudinal observations over multiple decades of three family clusters, including monozygotic twins with non-discordant HCC, that demonstrate...
Source: Current Cancer Therapy Reviews - September 14, 2020 Category: Cancer & Oncology Source Type: research
