Molecular Pathways, Screening and Follow-up of Colorectal Carcinogenesis: An Overview
Colorectal cancer (CRC) is the development of cancer from the colon or rectum. This kind of cancer presents with a broad spectrum of neoplasms from benign to metastatic forms. The development of the majority of colon cancers appears from adenomatous polyps or adenomas systematically. At least three molecular pathways are involved in CRC pathogenesis including chromosomal instability (CIN), microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP). Methods such as fecal occult blood tests (FOBTs), colonoscopy, flexible sigmoidoscopy (FOS), computed tomographic colonography (CTC), and fecal DNA are comm...
Source: Current Cancer Therapy Reviews - June 30, 2020 Category: Cancer & Oncology Source Type: research
Meet our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 30, 2020 Category: Cancer & Oncology Source Type: research
Development of MatLab Coding for Early Detection of Leukemia through Automated Analysis of RBCs
Background: Bone marrow biopsy has become an integral part of leukemia diagnosis and its treatment. Several advancements are being made towards the analysis of digital images of biopsy samples. Recently, the FDA approved the procedures of digital health. In tune with that, digital image analysis has become propelled. With the advent of high-throughput technologies, the scientific community focuses on the red blood cells (RBCs) for early detection of cancer, including leukemia. The reasons are due to their abundance in peripheral blood and hence, easily accessible compared to the bone marrow biopsy procedure. High magnifica...
Source: Current Cancer Therapy Reviews - June 10, 2020 Category: Cancer & Oncology Source Type: research
Development, Characterization and Anticancer Evaluation of Silver Nanoparticles from Dalbergia sissoo Leaf Extracts
Conclusion: The particle size of nanoparticles was found to lie in the range of 10 to 50 nm. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 10, 2020 Category: Cancer & Oncology Source Type: research
Dickkopf-1 and β-catenin as Biomarkers for Early Diagnosis of Hepatocellular Carcinoma
Background & Aims: The clinical value of alpha-fetoprotein (AFP) as a marker to detect early hepatocellular carcinoma (HCC) has been questioned owing to its low sensitivity and specificity. The purpose of this work was to investigate whether serum Wnt/β-catenin and DKK1 levels in chronic hepatitis C patients could be used as early predictors for the risk of HCC development. Methods: The study was conducted on 37 healthy controls, and 150 CHC patients were divided into three groups: CHC, liver cirrhosis (LC), and HCC patients. AFP, AFP-L3, β-catenin, and DKK-1 were assayed by ELISA. Results: Both β-catenin an...
Source: Current Cancer Therapy Reviews - June 10, 2020 Category: Cancer & Oncology Source Type: research
Demographic and Clinical Evaluation of Patients with Pancreatic Cancer in Mashhad University of Medical Sciences During 2002-2013
This study includes all data from real charts of patients with a definitive diagnosis of pancreatic cancer, admitted to Ghaem, Imam Reza, and Omid hospitals from 2002 to 2013. All the data which were available in lab results, exams, and patient files, were used accordingly. Results: 348 pancreatic cancer patients entered the study. About 61.5% of the subjects were men. Mean age was 59.67±14.37 years. Main complaints were abdominal pain (42.53%), jaundice (13.79%) or both (37.07%). We found a positive history of cancer in the first-degree relatives of 3.7% of patients, with the most prevalent being gastric cancer (46.1%). ...
Source: Current Cancer Therapy Reviews - June 10, 2020 Category: Cancer & Oncology Source Type: research
Solanum nigrum Anticancer Effect Through Epigenetic Modulations in Breast Cancer Cell Lines
Background: DNA methylation plays an important role in the regulation of gene expression in mammalian cells and often occurs at CpG islands in the genome. It is more reversible than genetic variations and has therefore attracted much attention for the treatment of many diseases, especially cancer. In the present study, we investigated the effect of Solanum nigrum Extract (SNE) on the methylation status of the VIM and CXCR4 genes in breast cancer cell lines. Methods: The Trypan blue assay was used to study the effect of SNE at various concentrations of 0, 0.1, 1.5, 2.5, 3.5 and 5 mg/ml for 48 h on the survival of three huma...
Source: Current Cancer Therapy Reviews - June 10, 2020 Category: Cancer & Oncology Source Type: research
Brachial Plexopathy as a Complication of Radiotherapy: A Systematic Review
Conclusion: From our findings, we can conclude that the issue of radiation-induced brachial plexus complication in human is of great concern. Common symptoms associated with this complication include paresthesia, numbness, pain and weakness. We recommend the use of individual dose planning and computer-assisted image segmentation techniques that support rapid and reliable contouring of the brachial plexus. Also, the radiation dose to the brachial plexus should be limited as much as possible to reduce the risk of brachial plexopathy. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 10, 2020 Category: Cancer & Oncology Source Type: research
New Researches about Combinatorial Therapeutic Regimen on Cancer Treatment
Cancer is a refractory disease, which brings physical, mental and economic sufferings on patients and their families. The activation of oncogenes and/or the deletion of tumor repressors result in uncontrolled tumor survival and proliferation. Therapeutic resistance and cancer recurrence are common issues during the course of clinical treatment. Since each single treatment can’t eradicate tumor cells completely, the development of combinatorial therapeutic regimen is in the spotlight for several decades. Combinatorial therapeutic regimen, a treatment modality that combines two or more therapeutic agents, targets key pathw...
Source: Current Cancer Therapy Reviews - June 10, 2020 Category: Cancer & Oncology Source Type: research
Molecular Pathways, Screening and Follow-up of Colorectal Carcinogenesis: An Overview
Colorectal cancer (CRC) is the development of cancer from the colon or rectum. This kind of cancer presents with a broad spectrum of neoplasms from benign to metastatic forms. The development of the majority of colon cancers appears from adenomatous polyps or adenomas systematically. At least three molecular pathways are involved in CRC pathogenesis including chromosomal instability (CIN), microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP). Methods such as fecal occult blood tests (FOBTs), colonoscopy, flexible sigmoidoscopy (FOS), computed tomographic colonography (CTC), and fecal DNA are comm...
Source: Current Cancer Therapy Reviews - June 10, 2020 Category: Cancer & Oncology Source Type: research
Meet our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - June 10, 2020 Category: Cancer & Oncology Source Type: research
Identifying the Optimal Fractionation Schedules for Improved Response Rates and Survival in Patients with Metastatic Melanoma Treated with Ipilimumab and Radiotherapy
Conclusion: This hypothesis-generating study suggests that patients who cannot receive ablative intent radiotherapy may be more likely to benefit from concurrent radiotherapy with ipilimumab if their fractionation schedule has a BED above 46.5 - 50.9 Gy. Prospective trials evaluating this question should be considered. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research
Virtual Screening of Novel Hybrid Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Exploring Multiple Targeted Cancer Therapy by an In Silico Approach
Conclusion: The study concluded that compound 2sa, 5sa, 6sa, and 7sa could be further explored for multiple targeted cancer therapy. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research
Cancer Immunotherapy: An Effective Tool in Cancer Control and Treatment
Conclusion: In the review, we described the significance of immunotherapy in the management of various types of cancer. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research
Possible Biomarkers and Therapeutic Targets for the Management of Cervical Cancer
Conclusion: In this study, we will discuss cervical cancer, its cause, symptoms, pathophysiology and treatments. Early screening and detection can help in reducing the overall burden of cervical cancer in the near future. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research
