Key Signaling Pathways Engaged in Cancer Management: Current Update
Conclusion: A noteworthy challenge for future medication advancement is to detail a synthesis treatment influencing distinctive targets to enhance the treatment of cancer. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research
Exploring Promises of siRNA in Cancer Therapeutics
Since the discovery of the RNA interference (RNAi) in 2006, several attempts have been made to use it for designing and developing drug treatments for a variety of diseases, including cancer. In this mini-review, we focus on the potential of small interfering RNAs (siRNA) in anticancer treatment. We first describe the significant barriers that exist on the path to clinical application of siRNA drugs. Then the current delivery approaches of siRNAs using lipids, polymers, and, in particular, polymeric carriers that overcome the aforementioned obstacles have been reviewed. Also, few siRNA mediated drugs currently in clinical ...
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research
Role of the Hsp90-Immunophilin Heterocomplex in Cancer Biology
The identification of new factors that may function as cancer markers and become eventual pharmacologic targets is a challenge that may influence the management of tumor development and management. Recent discoveries connecting Hsp90-binding immunophilins with the regulation of signalling events that can modulate cancer progression transform this family of proteins in potential unconventional factors that may impact on the screening and diagnosis of malignant diseases. Immunophilins are molecular chaperones that group a family of intracellular receptors for immunosuppressive compounds. A subfamily of the immunophilin famil...
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research
Recent Advances of Novel Therapeutic Agents from Botanicals for Prevention and Therapy of Breast Cancer: An Updated Review
Breast cancer is among the foremost common malignancies and the second leading cause for cancer-related deaths in females. Varied treatment approaches are projected to cause a subject matter reduction in the fatality rate. Carcinoma treatment is highly challenging due to therapeutic resistance and reoccurrence. Several studies have revealed that bioactive compounds isolated from natural products such as plants, vegetables, and marine origins have a therapeutic and preventive role in breast carcinoma. Utilization of these bioactive agents in amelioration of cancer as complementary and alternative therapy increases day by da...
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research
Targeted Nanomedicines: In the Right Route Towards Improved Therapies
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research
Preface
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research
Meet our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 6, 2020 Category: Cancer & Oncology Source Type: research
Acknowledgements to reviewers
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research
The Cancer Hygiene Hypothesis: From Theory to Therapeutic Helminths
Conclusion: Here we discuss the major implications of these findings for the association between microorganisms and cancer, and also between some immune pathologies, like autoimmune diseases, and cancer. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research
In Silico Analysis and Molecular Docking Studies of Novel 6,7-dihydropyrano [2,3-d] pyrimidin-5-one Derivatives as Human Epidermal Growth Factor Receptor 2 (HER2) and Epidermal Growth Factor Receptor (EGFR) Inhibitors
Conclusion: The bioactivity prediction shows that all compounds are active to moderately active. These positive results show that it could be further investigated and explored. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research
Crocins: The Active Constituents of Crocus Sativus L. Stigmas, Exert Significant Cytotoxicity on Tumor Cells In Vitro
Conclusion: Our data demonstrate that crocins could be a novel promising agent for the improvement of tumor treatment. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research
A Model for Heterogeneous Brain Tumor Cells that Cause Dizziness
Conclusion: The positive and negative points of the image-based cell models and computergenerated cell models some scientific advices are presented in this work. Generally, the imagebased cell models could offer analytical facts for each state, but they are expensive and timeconsuming; besides, their performance is heavily influenced by deformation techniques. The computer-generated cell model, on the other hand, provides a higher cost of production and simplicity, but its main contribution is the overall performance and accuracy. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research
Main Nutritional and Environmental Risk Factors in Children with Leukemia from a Public Hospital of the State of Guanajuato, Mexico
Conclusion: The main nutritional and environmental risk factors found were early complementary feeding, cow’s milk prior to 1 year of age, a duration of breastfeeding of fewer than 6 months, birth weight of>3,500 g, a positive smoking habit in the children’s parents, as well as exposure to arsenic in drinking water. Identification of these risk factors could constitute an input for integrating novel prevention alternatives and the nutritional management of leukemia. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research
Efficacy and Safety of Targeting Androgen Receptor in Advanced Breast Cancer: A Systematic Review
Conclusion: Androgen receptor pathway targeting in advanced breast cancer remains a valid option with reasonable clinical benefit in non-selected patients. Future studies are needed to define an AR addicted cohort with better responses and outcome. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research
Crocetin as an Active Secondary Metabolite of Saffron Stigma and Anticancer Effects
This study aimed to review previous invitro and invivo investigations on anticancer effects of this carotenoid and also proposed molecular mechanisms of its action. Literature reviewing between 1990 and 2017 was performed using pubmed and scopus databases. Anti-proliferative and pro-apoptotic effects of crocetin have been observed in several cancers cell lines and also model organisms that might be due to the alternation in the expression of cancer-related genes and epigenetic changes. Moreover, several studies indicated synergistic effects of crocetin with common chemotherapy agents and mentioned it as a potential novel a...
Source: Current Cancer Therapy Reviews - November 17, 2019 Category: Cancer & Oncology Source Type: research
