Therapeutic Peptide Mimetics Looking for a Turn to Block Aberrant Players of Malignancy
Conclusion: This review discusses emerging issues and potential avenues related to the scope and limitations of peptide mimetics in cancer treatment. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 15, 2017 Category: Cancer & Oncology Source Type: research
Current and Emerging Therapy for Malignant Pleural Mesothelioma: Focus on CD26/Dipeptidyl Peptidase IV as a Therapeutic Target
Conclusion: This review highlights the areas of most promise in treating MPM, these include immune checkpoint blockade, passive immunization, and based on our recently published data, targeting of CD26 with its specific mAb. Finally we describe how the anti-CD26 mAb YS110 was recently evaluated in the first-in-human phase I clinical trial, showing prolonged disease stabilization and a favorable side effect profile. Through better understanding of CD26, new pathways to treating and potentially curing malignant mesothelioma may be discovered. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 15, 2017 Category: Cancer & Oncology Source Type: research
Meet Our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - November 15, 2017 Category: Cancer & Oncology Source Type: research
Targeted Nanosystems for Cancer Therapy
Conclusion: Here we provide an update on the recent clinical trials in nanocarrier based therapy of colon rectal cancer, food and drug administration (FDA) approved nanomedicines for cancer and those in nanoplatforms which have reached an advanced stage of clinical development. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - August 29, 2017 Category: Cancer & Oncology Source Type: research
Inhibition of Angiogenesis as a Treatment Strategy for Neuroblastoma
Background: Angiogenesis stands as a symbol for the development of tumor as well as its metastasis. In this review, we discuss the various components that induce and enhance angiogenesis along with its several inhibitors in neuroblastoma. Angiogenesis is vital for tumor development and migration and it is dependent on the creation of angiogenic elements by tumor cell lines. Methodology: Neuroblastoma (NB) is a general pediatric tumor which originates from neural crest that is biologically and physiologically diverse. As tumor vascular index increases, it leads to the unfavorable consequence of NB. Tumor vascularity is very...
Source: Current Cancer Therapy Reviews - August 29, 2017 Category: Cancer & Oncology Source Type: research
Phenothiazines and Related Drugs as Multi Drug Resistance Reversal Agents in Cancer Chemotherapy Mediated by p-glycoprotein
Conclusion: This review will discuss the work done on the SAR and QSAR of phenothiazines as anti-MDR agents along with their putative mechanism of action as MDR reversal agents. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - August 29, 2017 Category: Cancer & Oncology Source Type: research
Cancer and Treatment Modalities
Conclusion: Over recent years, radiotherapy techniques have been greatly developed which create various suitable conditions for the treatment of different cancers while sparing normal tissues. As the radiotherapy techniques developed, tumor covering and precision on dose delivery increased. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - August 29, 2017 Category: Cancer & Oncology Source Type: research
Erlotinib: A Targeted Anticancer Drug
Conclusion: In nonclinical toxicology studies, the drug has not shown any results of fertility impairment, carcinogenesis or mutagenesis. Though the EGFR-TKIs have shown great clinical significance, the development of drug resistance has also been reported by the patients. The resistance for EGFR-TKIs can occur through any of the several mechanisms involved like secondary mutation (T790M), ATP binding cassette transporter effusion, alteration of the downstream pathways, etc. This article reviews the safety and efficacy of erlotinib along with chemistry, mechanism, pharmacokinetics, drug interactions and resistance to the d...
Source: Current Cancer Therapy Reviews - August 29, 2017 Category: Cancer & Oncology Source Type: research
Preface
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - August 29, 2017 Category: Cancer & Oncology Source Type: research
Meet Our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - August 29, 2017 Category: Cancer & Oncology Source Type: research
Acknowledgements to reviewers
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - May 11, 2017 Category: Cancer & Oncology Source Type: research
DMBA- Induced Breast Cancer: A Hormonal Camouflage
Conclusion: Conclusively, DMBA induced breast cancer is a suitable model for mucinous carcinoma in estrogen and human epidermal receptor-2 negative and progesterone positive breast cancer. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - May 11, 2017 Category: Cancer & Oncology Source Type: research
Novel Drug Delivery System for Cancer Management: A Review
Conclusion: Herbal formulations improve component solubility, enhance bioavailability, assist in dose reduction, help in achieving constant therapeutic dose over extended time, enhance stability, and protect physical and chemical degradation. Herbal formulations have more advantages in comparison to conventional formulation. Hence, the use of novel drug delivery system for herbal medicines is more beneficial in comparison to others. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - May 11, 2017 Category: Cancer & Oncology Source Type: research
Understanding Unmet Needs in the Older Acute Myeloid Leukemia (AML) Patient
Conclusion: The current paper seeks to describe these specific needs and their associated barriers related to treatment, prognostic factors and relapse, health-related quality of life, disease costs, and palliative care support. Acquiring a better understanding of AML for elderly patients can lead to improved therapy options and quality-of-life for this population. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - May 11, 2017 Category: Cancer & Oncology Source Type: research
Interferon Therapy in Lung Cancer: Current Perspectives
Conclusion: Interferons have been found to be effective in both types of lung cancer even in advanced stage. IFN α & β (type I IFN) have been extensively tried in various experimental models of lung cancer and clinical cases and have been found to be effective while other types and sub types of interferon like IFN gamma have also been tried in several cases of lung cancer and have yielded varied results. Studies are still in progress and we are looking ahead for further achievements related to potential and effective interferon therapy against pulmonary malignancies. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - May 11, 2017 Category: Cancer & Oncology Source Type: research
