Prophylaxis of Cancer
Conclusion: By regular exercise and taking the correct treatment, a cancer patient can also survive for more time. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - May 11, 2017 Category: Cancer & Oncology Source Type: research
Meet Our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - May 11, 2017 Category: Cancer & Oncology Source Type: research
Systemic Delivery of Nanoformulations of Anti-cancer Drugs with Therapeutic Potency in Animal Models of Cancer
Despite being widely used for cancer treatment, conventional chemotherapeutic regimens based on anti-cancer drugs possess significant drawbacks in discriminating between normal and cancer cells, leading to detrimental effects on healthy tissues. The development of nano-formulations encapsulating the chemotherapy drugs is highly expected to improve the anti-cancer activities with favorable pharmacokinetic profile and consequentially minimized side-effects. Several organic and inorganic nanoparticles have received tremendous attention as carriers of various anticancer drugs in pre-clinical and clinical settings. In this revi...
Source: Current Cancer Therapy Reviews - February 17, 2017 Category: Cancer & Oncology Source Type: research
Melanoma
is a common aggressive skin cancer. Its numerous genetic mutations have become rich targets for systemic therapy with chemotherapy or immunotherapy. Surgery is the best initial treatment. Completion nodal dissection for sentinel node positive patients decrease regional occurrence but no survival benefit was found in a few studies. Radiotherapy (RT) is used as primary, adjuvant and palliative treatment. Specific scenarios with unknown primary, head and neck melanomas, and distant metastases are discussed. Systemic therapy includes molecular therapy based on diver mutation or immunotherapy. Treatment guidelines should be ut...
Source: Current Cancer Therapy Reviews - February 17, 2017 Category: Cancer & Oncology Source Type: research
Chemotherapy and Molecular Therapy in Non-Melanoma Skin Cancer
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the commonest skin malignancies and if diagnosed early have a good prognosis. Conversely, metastatic disease is rarely associated with a very poor prognosis. Locally advanced BCC is also uncommon and may not be amendable to surgery, radiation therapy or photodynamic therapy. The activation of the hedgehog pathway occurs in 90% of BCCs and inhibition of this pathway with well tolerated oral agents has resulted in an important therapeutic option in some patients with locally advanced or metastatic BCC. In contrast, metastatic SCC tends to behave biologically mo...
Source: Current Cancer Therapy Reviews - February 17, 2017 Category: Cancer & Oncology Source Type: research
Managing Skin Malignancies- How Family Doctors, Plastic Surgeons, and Dermatologists Can Help
Skin cancer is common. General practitioners, general surgeons, dermatologists, and plastic surgeons all play a role in the management of cutaneous malignancies. Because patients are in contact with their primary care physicians more frequently, primary care physicians are instrumental in early detection and non-surgical management. Additionally, patient survival is statistically improved when a dermatologist is involved in patient care. Significant overlap in scope of practice exists, particularly between plastic surgeons and dermatologists. Either specialty may perform wide local excision or Mohs microsurgery as the defi...
Source: Current Cancer Therapy Reviews - February 17, 2017 Category: Cancer & Oncology Source Type: research
Non-Melanoma Skin Cancer – Overview
Non-Melanoma Skin Cancer (NMSC) is the most common form of skin cancer. Common risk factors linked to the occurrence of NMSC are occupational exposure to chemicals, ultraviolet light exposure, immunosuppresion, human papillomavirus infection, artificial tanning, premalignant skin lesions and inherited skin conditions. The various clinical manifestations of NMSC depend on location and subtype. Management of NMSC includes pathology confirmation, staging and treatment. Retinoid and nicotinamide have been shown to be effective for the prevention of NMSC, primary treatments available for the treatment of NMSC are wide local exc...
Source: Current Cancer Therapy Reviews - February 17, 2017 Category: Cancer & Oncology Source Type: research
Editorial (Thematic Issue: Current Treatments for Skin Cancer Part 2)
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 17, 2017 Category: Cancer & Oncology Source Type: research
Meet Our Editorial Board Member
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - February 17, 2017 Category: Cancer & Oncology Source Type: research
Editorial (Thematic Issue :Current Treatments for Skin Cancer)
(Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - December 30, 2016 Category: Cancer & Oncology Source Type: research
Photodynamic Therapy: The Light Treatment for Cutaneous Non- Melanoma Malignancies
Photodynamic therapy has many treatment applications for malignant and premalignant lesions of the skin. The basic principle involves application of a photosensitizer followed by exposure of the target tissues to light. 5-aminolevulinic acid is a natural occurring compound in the heme biosynthesis pathway. Its metabolite protoporphyrin IX is a photosensitizer that has the ability to selectively damage premalignant, malignant, and certain abnormal tissues, rendering its wide application for use in actinic keratosis, Bowen’s disease, and basal cell carcinoma. Adequate lesion preparation is critical for successful treatment...
Source: Current Cancer Therapy Reviews - December 30, 2016 Category: Cancer & Oncology Source Type: research
Radiotherapy for Non-Melanoma Skin Cancer
This review summarizes techniques, indications and contraindications for radiotherapy for non-melanoma skin cancer. Different radiotherapy techniques including brachytherapy, electron treatments, photon treatments with electronic brachytherapy, linear accelerator, and orthovoltage machines are available. Radiation oncologists have to select the best technique for different sites and scenarios. Details of specific radiotherapeutic preparation and clinical care discussed in this review will be of great help to the reader at the point of care. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - December 30, 2016 Category: Cancer & Oncology Source Type: research
Treatment Decisions for Non-Melanoma Skin Cancer (NMSC)
Selection of treatment for non-melanoma skin cancer (NMSC) takes into account many factors, including different host, tumor and treatment factors. Examples of these factors are presented. Ultimately the treatment decision is affected by the availability of surgical, dermatological, radiotherapeutic expertise and supportive resources. Different treatment options are discussed in this review. After appropriate education and guidance, patients' wish should take the first priority. The treatment of skin cancer requires experience, and discussion in multidisciplinary team meetings is strongly encouraged. (Source: Current C...
Source: Current Cancer Therapy Reviews - December 30, 2016 Category: Cancer & Oncology Source Type: research
Pattern of Care for Skin Cancers - Canada and France
Canada and France do not have a lot of sunshine but skin cancer is still the most common tumor. The majority of the population is white. The pattern of care for skin cancers is similar to the delivery of care for other cancers. No extra resources are allocated to skin cancer. The general practitioners are the first care providers for skin cancers. Excision or biopsy of the skin lesion establishes the diagnosis. If residual disease is present, further treatments are provided by general practitioners, dermatologists, general or plastic surgeons and radiation oncologists. If adjuvant or definitive treatments are required, pat...
Source: Current Cancer Therapy Reviews - December 30, 2016 Category: Cancer & Oncology Source Type: research
Recurrent Scalp Lesions from Glioblastoma: Case Report and Literature Review
We report a case of a 60-year-old man who presented recurrent scalp lesions from glioblastoma. This illustrative case highlights the importance of suspicious of disease spread in patients with glioblastoma who present with scalp lesions after surgery. Also, we review the literature concerning epidemiology, pathogenesis, treatment, and prognosis. (Source: Current Cancer Therapy Reviews)
Source: Current Cancer Therapy Reviews - December 30, 2016 Category: Cancer & Oncology Source Type: research
