Contrast Media and Molecular Imaging Contrast Media and Molecular Imaging RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Issue Information
No abstract is available for this article. (Source: Contrast Media and Molecular Imaging)
Source: Contrast Media and Molecular Imaging - July 31, 2016 Category: Radiology Tags: Issue Information Source Type: research

Surgical tissue handling methods to optimize ex vivo fluorescence with the activatable optical probe γ‐glutamyl hydroxymethyl rhodamine green
Contrast Media&Molecular Imaging,Volume 11, Issue 6, Page 572-578, November/December 2016. (Source: Contrast Media and Molecular Imaging)
Source: Contrast Media and Molecular Imaging - July 22, 2016 Category: Radiology Source Type: research

---
Contrast Media&Molecular Imaging,Volume 11, Issue 6, Page 572-578, November/December 2016. (Source: Contrast Media and Molecular Imaging)
Source: Contrast Media and Molecular Imaging - July 22, 2016 Category: Radiology Source Type: research

MR imaging, targeting and characterization of pulmonary fibrosis using intra ‐tracheal administration of gadolinium‐based nanoparticles
Idiopathic pulmonary fibrosis is a devastating disease. Animal models are critical to develop new diagnostic approaches. We investigate here whether the application of an ultra‐short echo time MRI sequence combined with the intra‐tracheal administration of Gd‐based nanoparticles can help to visualize and characterize pulmonary fibrosis in mice. 21 mice were imaged. Treated mice were administered bleomycin. MRI was used for longitudinal detection of bleomycin‐induced lung injury from Day 1 up to Day 60. On Day 30, all mice received nanoparticles and MR images were acquired. A signal enhancement of 120% and 50% in fi...
Source: Contrast Media and Molecular Imaging - July 10, 2016 Category: Radiology Authors: Nawal Tassali, Andrea Bianchi, Fran çois Lux, Gérard Raffard, Stéphane Sanchez, Olivier Tillement, Yannick Crémillieux Tags: Full paper Source Type: research

Uptake and retention of manganese contrast agents for PET and MRI in the rodent brain
Manganese‐enhanced magnetic resonance imaging (MRI) is an established neuroimaging method for signal enhancement, tract tracing, and functional studies in rodents. Along with the increasing availability of combined positron emission tomography (PET) and MRI scanners, the recent development of the positron‐emitting isotope 52Mn has prompted interest in the use of Mn2+ as a dual‐modality contrast agent. In this work, we characterized and compared the uptake of systemically delivered Mn2+ and radioactive 52Mn2+ in the rat brain for MRI and PET, respectively. Additionally, we examined the biodistribution of two formulati...
Source: Contrast Media and Molecular Imaging - July 10, 2016 Category: Radiology Authors: Christina L. Brunnquell, Reinier Hernandez, Stephen A. Graves, Ivy Smit‐Oistad, Robert J. Nickles, Weibo Cai, M. Elizabeth Meyerand, Masatoshi Suzuki Tags: Full paper Source Type: research

A novel Tc ‐99 m and fluorescence labeled peptide as a multimodal imaging agent for targeting angiogenesis in a murine tumor model
The serine–aspartic acid–valine (SDV) peptide binds specifically to integrin αVβ3. In the present study, we successfully developed a TAMRA–GHEG–ECG–SDV peptide labeled with both Tc‐99 m and TAMRA to target the integrin αVβ3 of tumor cells; furthermore, we evaluated the diagnostic performance of Tc‐99 m TAMRA–GHEG–ECG–SDV as a dual‐modality imaging agent for tumor of the murine model. TAMRA–GHEG–ECG–SDV was synthesized using Fmoc solid‐phase peptide synthesis. Radiolabeling of TAMRA–GHEG–ECG–SDV with Tc‐99 m was done using ligand exchange methods. Labeling stability and cytoto...
Source: Contrast Media and Molecular Imaging - June 30, 2016 Category: Radiology Authors: Myoung Hyoun Kim, Chang Guhn Kim, Seul ‐Gi Kim, Dae‐Weung Kim Tags: Full paper Source Type: research

Improved specific loss power on cancer cells by hyperthermia and MRI contrast of hydrophilic FexCo1 ‐xFe2O4 nanoensembles
This study lays the ground work for further characterization of other mixed spinel ferrites, and in addition we expect that chitosan and PEG coated FexCo1‐xFe2O4 of all the compositions will have good potential for preclinical applications in vivo. Copyright © 2016 John Wiley & Sons, Ltd. (a) Suppression of Hc, Mr by surface modification (b) Necrosis of 9L‐Gliosarcoma cells due to enhanced SLP (c) Concentration dependence of darkening (above); determination of 1/T2 relaxation(below) of FexCo1‐xFe2O4. (Source: Contrast Media and Molecular Imaging)
Source: Contrast Media and Molecular Imaging - June 30, 2016 Category: Radiology Authors: S. Manjura Hoque, Yuegao Huang, Emiliano Cocco, Samuel Maritim, Alessandro D. Santin, Erik M. Shapiro, Daniel Coman, Fahmeed Hyder Tags: Full paper Source Type: research

In vivo and ex vivo 19 ‐fluorine magnetic resonance imaging and spectroscopy of beta‐cells and pancreatic islets using GLUT‐2 specific contrast agents
In this study, we confirmed that, similar to DMH, 19FMHs inhibit insulin secretion and increase the blood glucose level in mice temporarily (approximately two hours). We were able to assess the distribution of 19FMHs in vivo with a temporal resolution of about 20 minutes, which showed a quick removal of 19FMH from the circulation (within two hours). Ex vivo MR spectroscopy confirmed a preferential uptake of 19FMH in tissue with high expression of the GLUT‐2 transporter, such as liver, endocrine pancreas and kidney. No indication of further metabolism was found. In summary, 19FMHs are potentially suitable for visualizin...
Source: Contrast Media and Molecular Imaging - June 30, 2016 Category: Radiology Authors: Sayuan Liang, Karim Louchami, Hauke Kolster, Anna Jacobsen, Ying Zhang, Julian Thimm, Abdullah Sener, Joachim Thiem, Willy Malaisse, Tom Dresselaers, Uwe Himmelreich Tags: Full paper Source Type: research

Myelin ‐targeted, texaphyrin‐based multimodal imaging agent for magnetic resonance and optical imaging
Reliable methods of imaging myelin are essential to investigate the causes of demyelination and to study drugs that promote remyelination. Myelin‐specific compounds can be developed into imaging probes to detect myelin with various imaging techniques. The development of multimodal myelin‐specific imaging probes enables the use of orthogonal imaging techniques to accurately visualize myelin content and validate experimental results. Here, we describe the synthesis and application of multimodal myelin‐specific imaging agents for light microscopy and magnetic resonance imaging. The imaging agents were synthesized by inc...
Source: Contrast Media and Molecular Imaging - June 30, 2016 Category: Radiology Authors: Sashiprabha M. Vithanarachchi, Casey D. Foley, Sarah Trimpin, James R. Ewing, Meser M. Ali, Matthew J. Allen Tags: Full paper Source Type: research

Fluorescent molecular imaging of metastatic lymph node using near ‐infrared emitting low molecular weight heparin modified nanoliposome based on enzyme‐substrate interaction
Tumor metastatic lymph node mapping has been widely used to predict the metastatic spread of primary tumor and guide the lymph node dissection in clinical practice. In this research, a new near‐infrared (NIR)‐emitting low molecular weight heparin (LMWHEP)‐modified Cy7‐loaded nanoliposome (LMWHEP‐NLips/Cy7) was developed and had the particle size of about 80 nm and the fluorescence intensity of about 2300, which is optimal for metastatic lymph node uptake and imaging. The NIR‐emitting nanoliposomes were designed by LMWHEP coating on the surface of Cy7‐loaded nanoliposome (NLips/Cy7) according to electrostati...
Source: Contrast Media and Molecular Imaging - June 30, 2016 Category: Radiology Authors: Tiantian Ye, Hefeng Zhang, Ge Chen, Lei Shang, Shujun Wang Tags: Full paper Source Type: research

Preclinical evaluation of [111In]MICA ‐401, an activity‐based probe for SPECT imaging of in vivo uPA activity
Urokinase‐type plasminogen activator (uPA) and its inhibitor PAI‐1 are key players in cancer invasion and metastasis. Both uPA and PAI‐1 have been described as prognostic biomarkers; however, non‐invasive methods measuring uPA activity are lacking. We developed an indium‐111 (111In)‐labelled activity‐based probe to image uPA activity in vivo by single photon emission computed tomography (SPECT). A DOTA‐conjugated uPA inhibitor was synthesized and radiolabelled with 111In ([111In]MICA‐401), together with its inactive, hydrolysed form ([111In]MICA‐402). A biodistribution study was performed in mice (healt...
Source: Contrast Media and Molecular Imaging - June 30, 2016 Category: Radiology Authors: Christel Vangestel, David Thomae, Jeroen Van Soom, Johan Ides, Leonie wyffels, Patrick Pauwels, Sigrid Stroobants, Pieter Van der Veken, Viktor Magdolen, Jurgen Joossens, Koen Augustyns, Steven Staelens Tags: Full paper Source Type: research

Biodistribution and evaluation of 131I ‐labeled neuropilin‐binding peptide for targeted tumor imaging
Neuropilin‐1 (NRP‐1) is overexpressed in several kinds of cancer cell and contributes to tumor aggressiveness. Recently, the arginine/lysine‐rich peptide with C‐terminal motifs (R/K)XX(R/K) indicated promising penetrating and transporting capability into NRP‐1 positive cancer cells. In the present study, we describe a 131I‐labeled C‐end rule motif peptide conjugate, Tyr–tLyp‐1, for NRP‐1 positive tumor targeting and imaging properties. Briefly, a truncated Lyp‐1 peptide was designed to expose its C‐end motif and conjugated to tyrosine for radiolabeling after structural modification. The peptide indi...
Source: Contrast Media and Molecular Imaging - June 30, 2016 Category: Radiology Authors: Ping Dong, Huawei Cai, Lihong Chen, Yalun Li, Cen Yuan, Xiaoai Wu, Guohua Shen, Huijun Zhou, Wenjie Zhang, Lin Li Tags: Full paper Source Type: research

64CuS ‐labeled nanoparticles: a new sentinel‐lymph‐node‐mapping agent for PET–CT and photoacoustic tomography
Determining sentinel lymph node (SLN) status is critical to cancer staging and treatment decisions. Currently, in clinical practice, 99mTc‐radiocolloid‐mediated planar scintigraphy and single‐photon emission computed tomography (SPECT) are used to guide the biopsy and resection of SLNs. Recently, an emerging technique that combines positron emission tomography (PET) and photoacoustic tomography (PAT; PET–PAT) may offer accurate information in detecting SLNs. Herein, we report a kind of 64CuS‐labeled nanoparticle (64CuS‐NP) for the detection of SLNs with PET–PAT. We subcutaneously injected 64CuS‐NPs into the...
Source: Contrast Media and Molecular Imaging - June 30, 2016 Category: Radiology Authors: Qiufang Liu, Min Zhou, Panli Li, Geng Ku, Gang Huang, Chun Li, Shaoli Song Tags: Full paper Source Type: research

Cellular internalization and morphological analysis after intravenous injection of a highly hydrophilic octahedral rhenium cluster complex – a new promising X‐ray contrast agent
The octahedral cluster compound Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] has been shown to be highly radio dense, thus becoming a promising X‐ray contrast agent. It was also shown that this compound had low cytotoxic effect in vitro, low acute toxicity in vivo and was eliminated rapidly from the body through the urinary tract. The present contribution describes a more detailed cellular internalization assay and morphological analysis after intravenous injection of this hexarhenium cluster compound at different doses. The median lethal dose (LD50) of intravenously administrated compound was calculated (4.67 ± 0.69 ...
Source: Contrast Media and Molecular Imaging - June 30, 2016 Category: Radiology Authors: Anna A. Krasilnikova, Anastasiya O. Solovieva, Kristina E. Trifonova, Konstantin A. Brylev, Anton A. Ivanov, Sung ‐Jin Kim, Michael A. Shestopalov, Maria S. Fufaeva, Alexander M. Shestopalov, Yuri V. Mironov, Alexander F. Poveshchenko, Lidia V. Shestopa Tags: Full paper Source Type: research

Co ‐precipitation of DEAE‐dextran coated SPIONs: how synthesis conditions affect particle properties, stem cell labelling and MR contrast
Superparamagnetic iron oxide nanoparticles (SPIONs) are widely used as contrast agents for stem cell tracking using magnetic resonance imaging (MRI). The total mass of iron oxide that can be internalised into cells without altering their viability or phenotype is an important criterion for the generation of contrast, with SPIONs designed for efficient labelling of stem cells allowing for an increased sensitivity of detection. Although changes in the ratio of polymer and iron salts in co‐precipitation reactions are known to affect the physicochemical properties of SPIONs, particularly core size, the effects of these synth...
Source: Contrast Media and Molecular Imaging - June 29, 2016 Category: Radiology Authors: Michael Barrow, Arthur Taylor, Jaime Garc ía Carrión, Pranab Mandal, B. Kevin Park, Harish Poptani, Patricia Murray, Matthew J. Rosseinsky, Dave J. Adams Tags: Full paper Source Type: research