Contrast Media and Molecular Imaging This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The reliability of parameters obtained by fitting of 1H NMRD profiles and 17O NMR data of potential Gd3+‐based MRI contrast agents
Synthetic variable temperature 1H NMRD profiles and 17O NMR relaxation and shift data were generated with a model based on the Solomon–Bloembergen–Morgan and Freed theories and then fitted simultaneously or individually. The effects of the fitting procedure and of experimental uncertainties on the resulting best‐fit parameters were investigated. The most reliable best‐fit parameters were obtained when all data were included in a simultaneous fitting procedure. Fitting of only NMRD and/or 17O NMR data provided considerably less accurate best‐fit parameters. Very large deviations from the values of the parameters u...
Source: Contrast Media and Molecular Imaging - November 1, 2015 Category: Radiology Authors: Joop A. Peters Tags: Full paper Source Type: research

Magnetite loaded Polypeptide‐PLGA multifunctional microbubbles for dual‐mode US/MR imaging
Magnetite loaded Polypeptide‐PLGA multifunctional microbubbles (Fe3O4/Polypeptide‐PLGA MMBs) that show superparamagnetic properties were prepared by a modified double emulsion method and employed as imaging agent for dual‐mode Ultrasound/Magnetic resonance (US/MR) imaging of prostatic cancer. The successful synthesis of MMBs was determined by Fourier Transform Infrared Spectrometer (FTIR), X‐ray diffraction (XRD), Transmission Electron Microscope (TEM), Scanning Electron Microscope (SEM), Atomic Absorption Spectroscopy (AAS) and vibrating sample magnetometer (VSM). The as‐prepared MMBs had a diameter of 700 nm an...
Source: Contrast Media and Molecular Imaging - November 1, 2015 Category: Radiology Authors: Ying Sun, Yunkai Zhu, Can Huang, Rongxin Li, Yaqing Chen, Yourong Duan Tags: Full paper Source Type: research

Issue Information
No abstract is available for this article. (Source: Contrast Media and Molecular Imaging)
Source: Contrast Media and Molecular Imaging - October 8, 2015 Category: Radiology Tags: Issue Information Source Type: research

Main applications of hybrid PET‐MRI contrast agents: a review
In medical imaging, the continuous quest to improve diagnostic performance and optimize treatment strategies has led to the use of combined imaging modalities. Positron emission tomography (PET) and computed tomography (CT) is a hybrid imaging existing already for many years. The high spatial and contrast resolution of magnetic resonance imaging (MRI) and the high sensitivity and molecular information from PET imaging are leading to the development of this new hybrid imaging along with hybrid contrast agents. To create a hybrid contrast agent for PET‐MRI device, a PET radiotracer needs to be combined with an MRI contrast...
Source: Contrast Media and Molecular Imaging - September 1, 2015 Category: Radiology Authors: A. Kiani, A. Esquevin, N. Lepareur, P. Bourguet, F. Le Jeune, JY. Gauvrit Tags: Review Source Type: research

Characterization of magnetic nanoparticles from Magnetospirillum Gryphiswaldense as potential theranostics tools
We investigated the theranostic properties of magnetosomes (MNs) extracted from magnetotactic bacteria, promising for nanomedicine applications. Besides a physico‐chemical characterization, their potentiality as mediators for magnetic fluid hyperthermia and contrast agents for magnetic resonance imaging, both in vitro and in vivo, are here singled out. The MNs, constituted by magnetite nanocrystals arranged in chains, show a superparamagnetic behaviour and a clear evidence of Verwey transition, as signature of magnetite presence. The phospholipid membrane provides a good protection against oxidation and the MNs oxidation...
Source: Contrast Media and Molecular Imaging - September 1, 2015 Category: Radiology Authors: T. Orlando, S. Mannucci, E. Fantechi, G. Conti, S. Tambalo, A. Busato, C. Innocenti, L. Ghin, R. Bassi, P. Arosio, F. Orsini, C. Sangregorio, M. Corti, M. F. Casula, P. Marzola, A. Lascialfari, A. Sbarbati Tags: Full paper Source Type: research

Assessment of DNA double‐strand breaks induced by intravascular iodinated contrast media following in vitro irradiation and in vivo, during paediatric cardiac catheterization
Paediatric cardiac catheterizations may result in the administration of substantial amounts of iodinated contrast media and ionizing radiation. The aim of this work was to investigate the effect of iodinated contrast media in combination with in vitro and in vivo X‐ray radiation on lymphocyte DNA. Six concentrations of iodine (15, 17.5, 30, 35, 45, and 52.5 mg of iodine per mL blood) represented volumes of iodinated contrast media used in the clinical setting. Blood obtained from healthy volunteers was mixed with iodinated contrast media and exposed to radiation doses commonly used in paediatric cardiac catheterizations ...
Source: Contrast Media and Molecular Imaging - September 1, 2015 Category: Radiology Authors: Richard Gould, Sonyia L. McFadden, Simon Horn, Kevin M. Prise, Philip Doyle, Ciara M. Hughes Tags: Full paper Source Type: research

Compartmentalization of Gd liposomes: the quenching effect explained
Cationic liposomes carrying high [Gd] can be used as efficient cell‐labeling agents. In a compartmentalized state, Gd can cause signal loss (relaxivity quenching). The contributions of liposomal [Gd], size and compartmentalization state to relaxivity quenching were assessed. The dependency of signal intensity (SI) on intraliposomal [Gd] was assessed comparing three different [Gd] (0.3, 0.6 and 1.0 M Gd) in both small (80 nm) and large (120 nm) cationic liposomes. In addition, five compartmentalization states were compared: free Gd, intact Gd liposomes, ruptured Gd liposomes, Gd liposomes in intact cells and Gd lipo...
Source: Contrast Media and Molecular Imaging - September 1, 2015 Category: Radiology Authors: Jamal Guenoun, Gabriela N. Doeswijk, Gabriel P. Krestin, Monique R. Bernsen Tags: Full paper Source Type: research

Refinement of adsorptive coatings for fluorescent riboflavin‐receptor‐targeted iron oxide nanoparticles
In this study we present the synthesis of different FMN‐coated ultrasmall superparamagnetic iron oxide nanoparticles (USPIOs) and their efficiency as targeting contrast agents. Since FMN alone cannot stabilize the nanoparticles, we used adenosine phosphates – AMP, ADP and ATP – as spacers to obtain colloidally stable nanoparticles. Nucleotides with di‐ and triphosphate groups were intended to increase the USPIO charge and thus improve zeta potential and stability. However, all nanoparticles formed negatively charged clusters with similar properties in terms of zeta potential (−28 ± 2 mV), relaxivity (228�...
Source: Contrast Media and Molecular Imaging - August 11, 2015 Category: Radiology Authors: Yoanna Tsvetkova, Nataliia Beztsinna, Jabadurai Jayapaul, Marek Weiler, Susanne Arns, Yang Shi, Twan Lammers, Fabian Kiessling Tags: Full paper Source Type: research

Hyperpolarized 6Li as a probe for hemoglobin oxygenation level
Hyperpolarization by dissolution dynamic nuclear polarization (DNP) is a versatile technique to dramatically enhance the nuclear magnetic resonance (NMR) signal intensity of insensitive long‐T1 nuclear spins such as 6Li. The 6Li longitudinal relaxation of lithium ions in aqueous solutions strongly depends on the concentration of paramagnetic species, even if they are present in minute amounts. We herein demonstrate that blood oxygenation can be readily detected by taking advantage of the 6Li signal enhancement provided by dissolution DNP, together with the more than 10% decrease in 6Li longitudinal relaxation as a conseq...
Source: Contrast Media and Molecular Imaging - August 11, 2015 Category: Radiology Authors: Riccardo Balzan, Mor Mishkovsky, Yana Simonenko, Ruud B. Heeswijk, Rolf Gruetter, Uzi Eliav, Gil Navon, Arnaud Comment Tags: Full paper Source Type: research

Equilibrium‐phase MR angiography: Comparison of unspecific extracellular and protein‐binding gadolinium‐based contrast media with respect to image quality
The purpose of this study was to compare contrast and image quality of whole‐body equilibrium‐phase high‐spatial‐resolution MR angiography using a non‐protein‐binding unspecific extracellular gadolinium‐based contrast medium with that of two contrast media with different protein‐binding properties. 45 patients were examined using either 15 mL of gadobutrol (non‐protein‐binding, n = 15), 32 mL of gadobenate dimeglumine (weakly protein binding, n = 15) or 11 mL gadofosveset trisodium (protein binding, n = 15) followed by equilibrium‐phase high‐spatial‐resolution MR‐angiography of four ...
Source: Contrast Media and Molecular Imaging - August 11, 2015 Category: Radiology Authors: Katharina Erb‐Eigner, Matthias Taupitz, Patrick Asbach Tags: Full paper Source Type: research

Issue Information
No abstract is available for this article. (Source: Contrast Media and Molecular Imaging)
Source: Contrast Media and Molecular Imaging - August 6, 2015 Category: Radiology Tags: Issue Information Source Type: research

MR tracking of SPIO‐labeled mesenchymal stem cells in rats with liver fibrosis could not monitor the cells accurately
Our previous study showed that in vivo magnetic resonance (MR) imaging is effective in tracking superparamagnetic iron oxide (SPIO)‐labeled bone marrow mesenchymal stem cells (BMSCs) in rats with liver fibrosis. SPIO‐labeling‐induced signal reduction on MR images was completely reversed within 15 days after transplantation. It is still unclear whether the signal changes in MR imaging could reflect the number of transplanted cells in the liver. In the present study, BMSCs of male rats were doubly labeled with enhanced green fluorescent protein (EGFP) and SPIO and injected intravascularly into female rats with liver fi...
Source: Contrast Media and Molecular Imaging - July 8, 2015 Category: Radiology Authors: Bin Zhou, Dan Li, Jiesheng Qian, Zhengran Li, Pengfei Pang, Hong Shan Tags: Full paper Source Type: research

How morphology influences relaxivity – comparative study of superparamagnetic iron oxide–polymer hybrid nanostructures
Superparamagnetic iron oxides (SPIOs) are widely used in MRI as T2 contrast agents, and interest is still growing. Here, the T2 relaxivity of three different SPIO–polymer hybrid morphologies, i.e. homogeneously distributed iron oxide within a polymer matrix, Janus‐like nanoparticles and polymer nanocapsules containing iron oxides, is studied. Making use of calculations based on theory for agglomerated systems, the obtained T2 values could be predicted for all different morphologies, except for nanocapsules. Nanocapsules, in contrast to full spheres, allow for water exchange between encapsulated water and bulk water, an...
Source: Contrast Media and Molecular Imaging - July 7, 2015 Category: Radiology Authors: Sandro Ebert, Markus B. Bannwarth, Anna Musyanovych, Katharina Landfester, Kerstin Münnemann Tags: Full paper Source Type: research

DW‐MRI and 18F‐FLT PET for early assessment of response to radiation therapy associated with hypoxia‐driven interventions. Preclinical studies using manipulation of oxygenation and/or dose escalation
Early markers of treatment response may help in the management of patients by predicting the outcome of a specific therapeutic intervention. Here, we studied the potential value of diffusion‐weighted MRI (DW‐MRI) and 18F‐fluorothymidine (18F‐FLT), markers of cell death and cell proliferation respectively, to predict the response to irradiation. In addition, dose escalation and/or carbogen breathing were used to modulate the response to irradiation. The studies were performed on two hypoxic rat tumor models: rhabdomyosarcoma and 9L‐glioma. The rats were imaged using MRI and PET before and two days after the treatm...
Source: Contrast Media and Molecular Imaging - July 1, 2015 Category: Radiology Authors: Ly‐Binh‐An Tran, Anne Bol, Daniel Labar, Oussama Karroum, Lionel Mignion, Vanesa Bol, Bénédicte F. Jordan, Vincent Grégoire, Bernard Gallez Tags: Full paper Source Type: research

Prostate cancer imaging of FSHR antagonist modified with a hydrophilic linker
In conclusion, 18F‐Al‐NOTA‐MAL‐FSH2 was successfully prepared in a one‐step method and showed better pharmacokinetics than 18F‐Al‐NOTA‐MAL‐FSH1. Favorable preclinical study revealed that 18F‐Al‐NOTA‐MAL‐FSH2 appears to be a promising candidate for FSHR‐positive tumor imaging. Copyright © 2015 John Wiley & Sons, Ltd. GGGRDN‐modified FSH1 reduced the liver accumulation and optimized the abdominal background visualized by microPET. (Source: Contrast Media and Molecular Imaging)
Source: Contrast Media and Molecular Imaging - July 1, 2015 Category: Radiology Authors: Chen Zhu, Qing Xu, Donghui Pan, Yuping Xu, Ping Liu, Runlin Yang, Lizhen Wang, Xinchen Sun, Shineng Luo, Min Yang Tags: Full paper Source Type: research