Post renal transplant pure red cell aplasia--is tacrolimus a culprit?
We report a case series of three renal transplant recipients who were on tacrolimus and presented with chronic transfusion requiring anemia due to PRCA. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - July 21, 2016 Category: Urology & Nephrology Authors: Patil, M. R., Choudhury, A. R., Chohwanglim, M., Divyaveer, S., Mahajan, C., Pandey, R. Tags: PURE RED CELL APLASIA Source Type: research
Pure red cell aplasia induced by epoetin zeta
We report on a 72-year-old patient who developed hypo-proliferative anaemia unresponsive to ESA following the administration of epoetin zeta subcutaneously for 7 months. On the basis of severe isolated hypoplasia of the erythroid line in the bone marrow and high-titre neutralizing anti-erythropoietin antibodies (Ab), a diagnosis of Ab-mediated PRCA was made. Epoetin zeta was discontinued and the patient was given steroids. This was associated with anaemia recovery. To our knowledge this is the first PRCA case related to epoetin zeta. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - July 21, 2016 Category: Urology & Nephrology Authors: Panichi, V., Ricchiuti, G., Scatena, A., Del Vecchio, L., Locatelli, F. Tags: PURE RED CELL APLASIA Source Type: research
Short-term effects of the DASH diet in adults with moderate chronic kidney disease: a pilot feeding study
Conclusions
These pilot data suggest that a reduced-sodium DASH dietary pattern does not cause acute metabolic events in adults with moderate CKD and may improve nocturnal BP. Definitive studies are needed to determine long-term effects of DASH in CKD. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - July 21, 2016 Category: Urology & Nephrology Authors: Tyson, C. C., Lin, P.-H., Corsino, L., Batch, B. C., Allen, J., Sapp, S., Barnhart, H., Nwankwo, C., Burroughs, J., Svetkey, L. P. Tags: CHRONIC KIDNEY DISEASE Source Type: research
Chronic kidney disease in children
Chronic kidney disease (CKD) is a major health problem worldwide. Although relatively uncommon in children, it can be a devastating illness with many long-term consequences. CKD presents unique features in childhood and may be considered, at least in part, as a stand-alone nosologic entity. Moreover, some typical features of paediatric CKD, such as the disease aetiology or cardiovascular complications, will not only influence the child's health, but also have long-term impact on the life of the adult that they will become. In this review we will focus on the unique issues of paediatric CKD, in terms of aetiology, clinical ...
Source: CKJ: Clinical Kidney Journal - July 21, 2016 Category: Urology & Nephrology Authors: Becherucci, F., Roperto, R. M., Materassi, M., Romagnani, P. Tags: CHRONIC KIDNEY DISEASE Source Type: research
Relapsing thrombotic microangiopathy and intravenous sustained-release oxycodone
We report a case of TMA secondary to intravenous use of sustained-release oxycodone, and the first case to demonstrate relapsing disease due to persistent intravenous opioid use. In cases such as these, TMA is suspected to be due to a polyethylene oxide (PEO) coating found on these drugs, and the disease is likely due to a directly toxic effect of PEO to endothelial cells. We hypothesize that there are unidentified genetic predispositions causing some persons to be susceptible to developing this disease. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - July 21, 2016 Category: Urology & Nephrology Authors: Nataatmadja, M., Divi, D. Tags: THROMBOTIC MICROANGIOPATHY Source Type: research
Thrombotic microangiopathy and human immunodeficiency virus in the era of eculizumab
We present a case of a patient with human immunodeficiency virus infection who developed TMA and was successfully treated with eculizumab. The effect of long-term treatment with this new medication is unknown, and further studies are needed to establish guidelines in the management of this condition. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - July 21, 2016 Category: Urology & Nephrology Authors: Jin, A., Boroujerdi-Rad, L., Shah, G., Chen, J. L. T. Tags: THROMBOTIC MICROANGIOPATHY Source Type: research
Pneumococcal hemolytic uremic syndrome and steroid resistant nephrotic syndrome
We report the case of a 12-year-old female with steroid-resistant nephrotic syndrome treated with adrenocorticotrophic hormone (H.P. Acthar® Gel), who developed pneumococcal pneumonia and subsequent pHUS. While nephrotic syndrome is a well-known risk factor for invasive pneumococcal disease, this is the first reported case of pHUS in an adolescent patient with nephrotic syndrome, and reveals novel challenges in the diagnosis, treatment and potential prevention of this complication. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - July 21, 2016 Category: Urology & Nephrology Authors: Groves, A. P., Reich, P., Sigdel, B., Davis, T. K. Tags: THROMBOTIC MICROANGIOPATHY Source Type: research
Provider acceptance of an automated electronic alert for acute kidney injury
Conclusions
The alert system was generally well received, although approval waned with time. Approval was correlated with the belief that this type of alert improved patient care. These findings suggest that perceived efficacy is critical to the success of future alert trials. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - July 21, 2016 Category: Urology & Nephrology Authors: Oh, J., Bia, J. R., Ubaid-Ullah, M., Testani, J. M., Wilson, F. P. Tags: ACUTE KIDNEY INJURY Source Type: research
The risk of acute kidney injury following transapical versus transfemoral transcatheter aortic valve replacement: a systematic review and meta-analysis
Conclusions
Our meta-analysis demonstrates an association between TA-TAVR and a higher risk of AKI. Future studies are required to assess the risks of moderate to severe AKI and mortality following TA-TAVR versus TF-TAVR. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - July 21, 2016 Category: Urology & Nephrology Authors: Thongprayoon, C., Cheungpasitporn, W., Gillaspie, E. A., Greason, K. L., Kashani, K. B. Tags: ACUTE KIDNEY INJURY Source Type: research
Granulomatous interstitial nephritis and Crohn's disease
In conclusion, granulomatous interstitial nephritis is a genuine extraintestinal manifestation of Crohn's disease, the treatment of which should include immunosuppressive agents. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - July 21, 2016 Category: Urology & Nephrology Authors: Timmermans, S. A. M. E. G., Christiaans, M. H. L., Abdul-Hamid, M. A., Stifft, F., Damoiseaux, J. G. M. C., van Paassen, P. Tags: KIDNEY IN SYSTEMIC DISEASE Source Type: research
Ofatumumab treatment in lupus nephritis patients
Rituximab is frequently used in systemic lupus erythematosus; however, side effects such as infusion-related reactions limit its use. In this case report, we describe, for the first time, treatment with ofatumumab in four patients with lupus nephritis. The treatment was well tolerated in three of the patients, and a reduction of proteinuria was seen in all cases. This emphasizes the importance of alternative B-cell-depleting therapies in patients with an initial good response to rituximab, but who develop side effects. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - July 21, 2016 Category: Urology & Nephrology Authors: Haarhaus, M. L., Svenungsson, E., Gunnarsson, I. Tags: KIDNEY IN SYSTEMIC DISEASE Source Type: research
Current and novel biomarkers in anti-neutrophil cytoplasm-associated vasculitis
Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is characterized by a variable disease course, with up to 50% of patients having one relapse within 5 years and many progressing to end-stage organ damage despite modern treatment strategies. Moreover, complications arising from treatment dominate the causes of mortality and morbidity both early and late during disease, especially in the elderly and those with severe renal involvement, and there is additional uncertainty as to how long treatment should be continued. There is, therefore, an urgent clinical need to identify robust biomarkers to better pred...
Source: CKJ: Clinical Kidney Journal - July 21, 2016 Category: Urology & Nephrology Authors: Draibe, J. B., Fulladosa, X., Cruzado, J. M., Torras, J., Salama, A. D. Tags: KIDNEY IN SYSTEMIC DISEASE Source Type: research
Kaliopenic nephropathy revisited
In the ‘older’ literature, a definitive renal pathology was described in patients with long-standing hypokalaemia and depletion of the body's potassium reserves. The topic is relevant because possibly a quite cheaply reversible element in the course of chronic kidney disease progression could be addressed. Earlier, pathologists drew attention to vacuolar changes in renal tubular epithelium accompanied by inflammatory interstitial changes in patients with potassium losses. The diagnostic term ‘kaliopenic nephropathy’ was coined to describe such patients. Kaliopenic nephropathy now receives less empha...
Source: CKJ: Clinical Kidney Journal - July 21, 2016 Category: Urology & Nephrology Authors: Elitok, S., Bieringer, M., Schneider, W., Luft, F. C. Tags: ELECTROLYTES Source Type: research
Continuous venovenous hemofiltration using customized replacement fluid for acute kidney injury with severe hypernatremia
We present a case of AKI with severe hypernatremia successfully treated with CRRT using commercial RF solutions customized to prevent rapid correction of hypernatremia. None of the few case reports published on hypernatremia and AKI requiring CRRT have included formulas to help modulate the sodium content in the solutions. We present an equation to facilitate adjustment of the sodium concentration in this setting. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - July 21, 2016 Category: Urology & Nephrology Authors: Paquette, F., Goupil, R., Madore, F., Troyanov, S., Bouchard, J. Tags: ELECTROLYTES Source Type: research
The utility and accuracy of four equations in predicting sodium levels in dysnatremic patients
Conclusions
Like similar studies in hypernatremic patients, the data suggest that hyponatremic modeling equations are not reliably accurate in predicting Na2 from Na1 and available clinical data regarding sodium, potassium and fluid balance over longer time frames (12–30 h). Our study was retrospective and was done in an inpatient setting and thus was subject to limitations and laboratory measurement variability, but showed that all four equations are not able to reliably predict Na2 from Na1 and inputs across a 12–30 h period. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - July 21, 2016 Category: Urology & Nephrology Authors: Hanna, R. M., Yang, W.-T., Lopez, E. A., Riad, J. N., Wilson, J. Tags: ELECTROLYTES Source Type: research
