A cohort study of insulin-like growth factor 1 and mortality in haemodialysis patients
Conclusion
Low IGF-1 levels associate with increased mortality in HD, independent of biomarkers of inflammation (hs-CRP) and PEW (creatinine, albumin). Serum albumin modulates the relationship between IGF-1 levels and mortality, indicating shared pathophysiological pathways with IGF-1. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Nilsson, E., Carrero, J. J., Heimburger, O., Hellberg, O., Lindholm, B., Stenvinkel, P. Tags: DIALYSIS Source Type: research
Investigating clinical predictors of arteriovenous fistula functional patency in a European cohort
Conclusions
In this European study, female gender was associated with twice the risk of AVF FTM and a lower-arm AVF with four times the risk of FTM. The FTM risk prediction model was not found to be discriminative in this population. Clinical risk factors for AVF FTM vary between populations; we would recommend that units investigate their own clinical predictors of FTM to maximize AVF functional patency and ultimately survival in dialysis patients. Clinical predictors of AVF FTM may not be sufficient on their own to improve vascular access functional patency rates. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Masengu, A., Maxwell, A. P., Hanko, J. B. Tags: DIALYSIS Source Type: research
Chronic kidney disease hotspots in developing countries in South Asia
In many developing countries in the South Asian region, screening for chronic diseases in the community has shown a widely varying prevalence. However, certain geographical regions have shown a high prevalence of chronic kidney disease (CKD) of unknown etiology. This predominantly affects the young and middle-aged population with a lower socioeconomic status. Here, we describe the hotspots of CKD of undiagnosed etiology in South Asian countries including the North, Central and Eastern provinces of Sri Lanka and the coastal region of the state of Andhra Pradesh in India. Screening of these populations has revealed cases of ...
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Abraham, G., Varughese, S., Thandavan, T., Iyengar, A., Fernando, E., Naqvi, S. A. J., Sheriff, R., Ur-Rashid, H., Gopalakrishnan, N., Kafle, R. K. Tags: CHRONIC KIDNEY DISEASE Source Type: research
Loin pain hematuria syndrome
(LPHS), first described in 1967, is a rare pain syndrome, which is not well understood. The syndrome is characterized by severe intermittent or persistent flank pain, either unilateral or bilateral, associated with gross or microscopic hematuria. LPHS is a diagnosis of exclusion as there still is not a consensus of validated diagnostic criteria, though several criteria have been proposed. The wide differential diagnosis would suggest a meticulous yet specific diagnostic work-up depending on the individual clinical features and natural history. Several mechanisms regarding the pathophysiology of LPHS have been proposed but...
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Zubair, A. S., Salameh, H., Erickson, S. B., Prieto, M. Tags: CHRONIC KIDNEY DISEASE Source Type: research
The Stockholm CREAtinine Measurements (SCREAM) project: protocol overview and regional representativeness
Conclusion
SCREAM represents the largest cohort to estimate the burden and healthcare implications of CKD in Sweden. The coverage and representativeness of the region of Stockholm was high and in accordance to both the commonness of creatinine assessment, and the medical indications for creatinine testing. The inclusion of individuals who sought medical care and had a creatinine test undertaken resulted in a slight over-representation of elderly and comorbid patients. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Runesson, B., Gasparini, A., Qureshi, A. R., Norin, O., Evans, M., Barany, P., Wettermark, B., Elinder, C. G., Carrero, J. J. Tags: CHRONIC KIDNEY DISEASE Source Type: research
Patient kidney disease knowledge remains inadequate with standard nephrology outpatient care
Conclusions
After a year of standard care at nephrology outpatient clinics there were some minor improvements in patient knowledge; however, patient understanding of CKD remained poor. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Gray, N. A., Kapojos, J. J., Burke, M. T., Sammartino, C., Clark, C. J. Tags: CHRONIC KIDNEY DISEASE Source Type: research
Multimodal treatment of calcific uraemic arteriolopathy (calciphylaxis): a case series
Conclusions
This series contributes to the build-up of case series reporting on the treatment of CUA, and will hopefully serve as a basis of well-conceived comparative effectiveness studies investigating the value of the combined interventions applied so far in this severe condition. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Russo, D., Capuano, A., Cozzolino, M., Napolitano, P., Mosella, F., Russo, L., Saviano, C., Zoccali, C. Tags: CKD-MBD Source Type: research
Clinical factors influencing the decision to transfuse after percutaneous native kidney biopsy
Conclusions
While patients with lower pre-PRB Hgb have more of the traditional risk factors for a complication after PRB, there was actually less clinically evident bleeding in these patients who were transfused. Although anemia itself has been considered to be a risk factor for a complication in the past, it more accurately represents only a predictor of receiving an erythrocyte transfusion. In the setting of the PRB, the decision for transfusion is influenced more by the severity of anemia at baseline as opposed to clinically evident bleeding. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Whittier, W. L., Sayeed, K., Korbet, S. M. Tags: GLOMERULONEPHRITIS Source Type: research
Rapidly progressive glomerulonephritis due to coexistent anti-glomerular basement membrane disease and fibrillary glomerulonephritis
We report a 68-year-old white woman who presented with RPGN with kidney biopsy demonstrating diffuse crescentic GN on light microscopy. By immunofluorescence, there was bright linear staining of the GBMs and smudgy mesangial staining for immunoglobulin G, C3, and kappa and lambda light chain. Electron microscopy revealed fibrillary deposits in the GBM and mesangium. A serum test for anti-GBM antibody was positive. To our knowledge, this is the first report of coexistence of fibrillary GN in a patient with anti-GBM disease. Electron microscopy is critical to identify the coexistence of other GN in patients presenting with c...
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Cheungpasitporn, W., Zacharek, C. C., Fervenza, F. C., Cornell, L. D., Sethi, S., Herrera Hernandez, L. P., Nasr, S. H., Alexander, M. P. Tags: GLOMERULONEPHRITIS Source Type: research
Post-streptococcal glomerulonephritis associated with atypical hemolytic uremic syndrome: to treat or not to treat with eculizumab?
A 7-year-old male with poststreptococcal glomerulonephritis (PSGN) developed hemolytic uremic syndrome (HUS) and achieved remission. He was treated with eculizumab for 1 year. The eculizumab was discontinued and the patient remained in remission. This is the 10th reported case of PSGN associated with HUS. The histopathological feature observed at the 1-year follow-up was indistinguishable from the expected findings in an individual with healed PSGN without associated HUS. The relatively good prognosis in most prior cases and the absence of any reported recurrences strongly suggest that this form of atypical HUS does not wa...
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Kakajiwala, A., Bhatti, T., Kaplan, B. S., Ruebner, R. L., Copelovitch, L. Tags: GLOMERULONEPHRITIS Source Type: research
Drug-induced Fanconi syndrome associated with fumaric acid esters treatment for psoriasis: a case series
Conclusions
FAEs treatment can cause drug-induced Fanconi syndrome, but the association has been reported infrequently. Female patients with psoriasis treated long term with FAEs seem to be particularly at risk. Physicians treating patients with FAEs should be vigilant and monitor for the potential occurrence of Fanconi syndrome. Measurement of the urinary albumin:total protein ratio is a suggested screening tool for tubular proteinuria in Fanconi syndrome. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Balak, D. M. W., Bouwes Bavinck, J. N., de Vries, A. P. J., Hartman, J., Neumann, H. A. M., Zietse, R., Thio, H. B. Tags: TUBULOINTERSTITIAL DISEASE DIAGNOSIS Source Type: research
The use of gallium-67 scintigraphy in the diagnosis of acute interstitial nephritis
Conclusions
Gallium-67 scintigraphy may be of interest in patients with a clinical suspicion of AIN, especially in those who are unable to undergo kidney biopsy. However, results need to be interpreted with caution and depend on the intensity of gallium-67 kidney uptake. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Graham, F., Lord, M., Froment, D., Cardinal, H., Bollee, G. Tags: TUBULOINTERSTITIAL DISEASE DIAGNOSIS Source Type: research
Hints to the diagnosis of uromodulin kidney disease
Conclusions
In the present study, UKD was detected in <1 in 1000 subjects who underwent renal biopsies. However, in subjects meeting all of the above criteria, abnormal THP accumulation was detected in 20% (3/15), suggesting that renal biopsy with immunostaining for THP is a good tool for diagnosing UKD. Also, low serum THP concentration detected in the present subjects might be a good diagnostic marker or important in understanding the pathogenesis of UKD. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Onoe, T., Yamada, K., Mizushima, I., Ito, K., Kawakami, T., Daimon, S., Muramoto, H., Konoshita, T., Yamagishi, M., Kawano, M. Tags: TUBULOINTERSTITIAL DISEASE DIAGNOSIS Source Type: research
Haemodialysis for paediatric acute kidney injury in a low resource setting: experience from a tertiary hospital in South West Nigeria
Conclusions
The outcome of haemodialysis for AKI in Nigeria is relatively good and is related to the underlying aetiology of AKI. In addition to peritoneal dialysis, intermittent haemodialysis may have a role in the management of paediatric AKI in low resource settings and should be supported. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Asinobi, A. O., Ademola, A. D., Alao, M. A. Tags: ACUTE KIDNEY INJURY Source Type: research
Computerized clinical decision support for the early recognition and management of acute kidney injury: a qualitative evaluation of end-user experience
Conclusions
Our study revealed themes similar to those previously described in non-AKI settings. Systems intruding on workflow, particularly involving complex interactions, may be unsustainable even if there has been a positive impact on care. The optimal balance between intrusion and clinical benefit of AKI CCDS requires further evaluation. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Kanagasundaram, N. S., Bevan, M. T., Sims, A. J., Heed, A., Price, D. A., Sheerin, N. S. Tags: ACUTE KIDNEY INJURY Source Type: research
