Hints to the diagnosis of uromodulin kidney disease

Conclusions
In the present study, UKD was detected in <1 in 1000 subjects who underwent renal biopsies. However, in subjects meeting all of the above criteria, abnormal THP accumulation was detected in 20% (3/15), suggesting that renal biopsy with immunostaining for THP is a good tool for diagnosing UKD. Also, low serum THP concentration detected in the present subjects might be a good diagnostic marker or important in understanding the pathogenesis of UKD.

Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Onoe, T., Yamada, K., Mizushima, I., Ito, K., Kawakami, T., Daimon, S., Muramoto, H., Konoshita, T., Yamagishi, M., Kawano, M. Tags: TUBULOINTERSTITIAL DISEASE DIAGNOSIS Source Type: research