Admission hyperuricemia increases the risk of acute kidney injury in hospitalized patients
Conclusions
Elevated admission SUA was associated with an increased risk for in-hospital AKI. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Cheungpasitporn, W., Thongprayoon, C., Harrison, A. M., Erickson, S. B. Tags: ACUTE KIDNEY INJURY Source Type: research
Serum uric acid and AKI: is it time?
Acute kidney injury (AKI) is a well-recognized complication in hospitalized patients, with associated mortality and morbidity. Studies that aim to prevent or reverse AKI using pharmacological and interventional therapies in clinical practice have been disappointing. Work is continuing to identify potentially modifiable risk factors for AKI. Early identification and modification of these risk factors may help prevent or favorably influence the outcome of AKI. The role of uric acid as a potential risk factor is being revisited in chronic kidney disease and AKI. Apart from the established crystal precipitation with profound h...
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Kaushik, M., Choo, J. C. J. Tags: ACUTE KIDNEY INJURY Source Type: research
Focus on renal congestion in heart failure
Hospitalizations due to heart failure are increasing steadily despite advances in medicine. Patients hospitalized for worsening heart failure have high mortality in hospital and within the months following discharge. Kidney dysfunction is associated with adverse outcomes in heart failure patients. Recent evidence suggests that both deterioration in kidney function and renal congestion are important prognostic factors in heart failure. Kidney congestion in heart failure results from low cardiac output (forward failure), tubuloglomerular feedback, increased intra-abdominal pressure or increased venous pressure. Regardless of...
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Afsar, B., Ortiz, A., Covic, A., Solak, Y., Goldsmith, D., Kanbay, M. Tags: CARDIOVASCULAR NEPHROLOGY Source Type: research
Modulation of stroke risk in chronic kidney disease
Stroke is the second most common cause of death and the leading cause of neurological disability worldwide, with huge economic costs and tragic human consequences. Both chronic kidney disease (CKD) and end-stage kidney disease are associated with a significantly increased risk of stroke. However, to date this has generated far less interest compared with the better-recognized links between cardiac and renal disease. Common risk factors for stroke, such as hypertension, hypercholesterolaemia, smoking and atrial fibrillation, are shared with the general population but are more prevalent in renal patients. In addition, factor...
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Arnold, J., Sims, D., Ferro, C. J. Tags: CARDIOVASCULAR NEPHROLOGY Source Type: research
What should the characteristics and attributes of an accredited nephrology training programme be? Looking for high standards
The Renal Section of the European Union of Medical Specialists is working towards harmonization and optimization of nephrology training across Europe and its Mediterranean borders. In addition to the need for harmonization of the heterogeneous time dedicated to training, it is necessary to ensure that the learning environment is of a sufficiently high standard to develop skilled specialists. Thus, there is a need to review the core educational infrastructure and resources that should be provided to trainees in order to be considered centres of excellence for nephrology training.
This review addresses most of the characteri...
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Gleeson, P. J., Slotki, I., Cannata-Andia, J. B., Lappin, D. W. P. Tags: NEPHROLOGY TRAINING AND WORKFORCE Source Type: research
The global nephrology workforce: emerging threats and potential solutions!
Amidst the rising tide of chronic kidney disease (CKD) burden, the global nephrology workforce has failed to expand in order to meet the growing healthcare needs of this vulnerable patient population. In truth, this shortage of nephrologists is seen in many parts of the world, including North America, Europe, Australia, New Zealand, Asia and the African continent. Moreover, expert groups on workforce planning as well as national and international professional organizations predict further reductions in the nephrology workforce over the next decade, with potentially serious implications. Although the full impact of this has...
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Sharif, M. U., Elsayed, M. E., Stack, A. G. Tags: NEPHROLOGY TRAINING AND WORKFORCE Source Type: research
Redox homeostasis, T cells and kidney diseases: three faces in the dark
The redox equilibrium is crucial for the maintenance of immune homeostasis. Here, we summarize recent data showing that oxidation regulates T-cell functions and that alterations of the redox equilibrium may play an important role in the pathogenesis of inflammatory conditions affecting the kidneys. We further discuss potential links between oxidation, T cells and renal diseases such as systemic lupus erythematosus, renal ischaemia/reperfusion injury, end-stage renal disease and hypertension. The basic understanding of oxidation as a means by which diseases are directly affected results in unexpected pathophysiological simi...
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Simeoni, L., Thurm, C., Kritikos, A., Linkermann, A. Tags: BASIC SCIENCE Source Type: research
Announcements
(Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Tags: ANNOUNCEMENTS Source Type: research
Treatment of amitriptyline intoxications by extended high cut-off dialysis
We report two cases of amitriptyline poisoning in which we measured the amitriptyline elimination using extended high cut-off (HCO) dialysis. Despite dialyser clearances of 33 and 58 mL/min, resulting in the reduction of initial serum concentrations by ~30%, only 211 and 920 µg of amitryptilin, respectively, (<3% of the ingested amount) could be recovered in the total collected dialysate. Hence, due to the high volume of distribution of amitriptyline, even HCO dialysis does not contribute substantially to the extracorporeal removal of amitryptilin. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Schmidt, J. J., Bertram, A., Kuhn-Velten, W. N., Suhling, H., Wiesner, O., Schneider, A., Kielstein, J. T. Tags: DIALYSIS Source Type: research
A 4-month programme of in-centre nocturnal haemodialysis was associated with improvements in patient outcomes
Conclusions
This single-centre study showed a 4-month programme of extended hours INHD is safe and associated with improvements in QOL measures, decreased UF rates and measures of dialysis adequacy. These data have been used to expand our service and inform the design of future randomized controlled trials to examine medical endpoints. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Graham-Brown, M. P. M., Churchward, D. R., Smith, A. C., Baines, R. J., Burton, J. O. Tags: DIALYSIS Source Type: research
Opinion of French nephrologists on renal replacement therapy: survey on their personal choice
Conclusion
Our survey on the theoretical choice of RTT suggests that the low PD rate in France cannot be explained by a negative opinion of PD among French nephrologists. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Lorcy, N., Turmel, V., Oger, E., Couchoud, C., Vigneau, C. Tags: DIALYSIS Source Type: research
Pseudomonas exit-site infection: treatment outcomes with topical gentamicin in addition to systemic antibiotics
Conclusion
Eradication of Pseudomonas ESI remains difficult even with the addition of topical gentamicin to the exit site. There should be a low threshold for catheter replacement. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Burkhalter, F., Clemenger, M., Haddoub, S. S., McGrory, J., Hisole, N., Brown, E. Tags: DIALYSIS Source Type: research
Nephrology care prior to end-stage renal disease and outcomes among new ESRD patients in the USA
Conclusions
This study represents the largest cohort of incident ESRD patients to date. Although we did not follow patients before ESRD onset, our findings, both at the individual patient and state levels, reflect the importance of early nephrology care among those with chronic kidney disease. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Gillespie, B. W., Morgenstern, H., Hedgeman, E., Tilea, A., Scholz, N., Shearon, T., Burrows, N. R., Shahinian, V. B., Yee, J., Plantinga, L., Powe, N. R., McClellan, W., Robinson, B., Williams, D. E., Saran, R. Tags: CKD CARE Source Type: research
Barriers to effective communication between veterans with chronic kidney disease and their healthcare providers
Conclusions
Several barriers to patient–provider communication prevent patients from meeting their information needs and perpetuate patient passivity. Future research should evaluate whether interventions that empower CKD patients to actively participate in their care increase knowledge and improve health outcomes. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Lederer, S., Fischer, M. J., Gordon, H. S., Wadhwa, A., Popli, S., Gordon, E. J. Tags: CKD CARE Source Type: research
Effects of exercise in the whole spectrum of chronic kidney disease: a systematic review
The objective of the study was to search for and appraise evidence on the effectiveness of exercise interventions on health endpoints in CKD patients. A systematic review was performed of randomized clinical trials (RCTs) designed to compare exercise with usual care regarding effects on the health of CKD patients. MEDLINE, EMBASE, Cochrane Central, Clinical Trials registry, and proceedings of major nephrology conference databases were searched, using terms defined according to the PICO (Patient, Intervention, Comparison and Outcome) methodology. RCTs were independently evaluated by two reviewers. A total of 5489 studies we...
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Barcellos, F. C., Santos, I. S., Umpierre, D., Bohlke, M., Hallal, P. C. Tags: CKD CARE Source Type: research
