Contribution of dysregulated serum magnesium to mortality in hemodialysis patients with secondary hyperparathyroidism: a 3-year cohort study
Conclusion
In hemodialysis patients with SHPT, dysregulated sMg is an important contributor to all-cause death. Further studies are warranted to examine whether or not correction of sMg improves survival. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Kurita, N., Akizawa, T., Fukagawa, M., Onishi, Y., Kurokawa, K., Fukuhara, S. Tags: CKD-MBD Source Type: research
Independent association between serum sclerostin levels and carotid artery atherosclerosis in prevalent haemodialysis patients
Conclusion
Sclerostin is independently associated with CIMT although further studies are needed. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Kirkpantur, A., Balci, M., Turkvatan, A., Afsar, B. Tags: CKD-MBD Source Type: research
Fibroblast growth factor 23 and parathyroid hormone predict extent of aortic valve calcifications in patients with mild to moderate chronic kidney disease
Conclusions
Extent of aortic valve calcification is associated to FGF-23 and PTH in naïve CKD patients with mild to moderate CKD. Further studies should examine whether FGF-23 assay should be included in routine clinical evaluation of CKD as part of cardiovascular risk stratification. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Di Lullo, L., Gorini, A., Bellasi, A., Morrone, L. F., Rivera, R., Russo, L., Santoboni, A., Russo, D. Tags: CKD-MBD Source Type: research
Where is the link between mineral bone markers and cardiovascular disease in CKD?
(Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Cozzolino, M., Pasquali, M. Tags: CKD-MBD Source Type: research
Proliferative glomerulonephritis with monoclonal immunoglobulin in renal allografts
Glomerulopathy due to dysproteinemia can have a wide spectrum of pathologic and clinical features based on specific characteristics of the abnormal protein and the response induced within the parenchymal tissue. Monoclonal immunoglobulin G (IgG) deposition can manifest as a different glomerular disease. Proliferative glomerulonephritis (GN) with monoclonal IgG deposits (PGNMID) is a unique entity mimicking immune complex GN that does not conform to any of those subtypes. IgG monoclonal granular deposition in the glomeruli with a pattern similar to immune complex disease suggested by C3 and C1q deposition should prompt cons...
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Al-Rabadi, L., Francis, J. M., Henderson, J., Ghai, S. Tags: GLOMERULONEPHRITIS Source Type: research
Ambulatory blood pressure and tubulointerstitial injury in patients with IgA nephropathy
Conclusions
These results suggest that the T score using the OC is the most relevant renal histopathological parameter associated with abnormalities of circadian blood pressure in IgAN patients. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Haruhara, K., Tsuboi, N., Koike, K., Kanzaki, G., Okabayashi, Y., Miyazaki, Y., Kawamura, T., Ogura, M., Yokoo, T. Tags: GLOMERULONEPHRITIS Source Type: research
A circulating permeability factor in focal segmental glomerulosclerosis: the hunt continues
Primary focal segmental glomerulosclerosis (FSGS) is one of the major causes of steroid-resistant nephrotic syndrome, and renal prognosis in patients with steroid-resistant FSGS is poor. It has been long speculated that a circulating permeability factor should be implicated in the pathogenesis of the disease because a substantial portion of the patients with primary FSGS experience recurrence shortly after transplantation. Although molecules such as cardiotrophin-like cytokine 1 (CLC-1) and anti-CD40 antibody have been proposed to be potential circulating permeability factors, a definitive factor remains to be discovered. ...
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Wada, T., Nangaku, M. Tags: GLOMERULONEPHRITIS Source Type: research
Plasma exchange for paediatric kidney disease--indications and outcomes: a single-centre experience
Background
Outcome data in paediatrics regarding the use of plasmapheresis for immunological kidney disease are scarce.
Objectives
We aimed to evaluate the role of plasmapheresis in children presenting with severe renal impairment secondary to immunological kidney diseases.
Methods
A retrospective chart review of children admitted between January 2009 and August 2013 to the Paediatric Nephrology Unit, Christian Medical College, Vellore, India, and requiring plasma exchange was undertaken. Demographic and clinical data were studied and descriptive statistics applied for analysis.
Results
Sixteen children underwent plasma...
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Reddy, S. K., Jahan, A., Chaturvedi, S., Agarwal, I. Tags: THROMBOTIC MICROANGIOPATHY Source Type: research
Eculizumab for rescue of thrombotic microangiopathy in PM-Scl antibody-positive autoimmune overlap syndrome
A 46-year-old female with interstitial lung disease presented with proximal muscle weakness, worsening hypertension, microangiopathic hemolysis, thrombocytopenia and deteriorating renal function. She had no sclerodactyly, but had abnormal capillaroscopy. She tested positive for PM-Scl antibodies, and a renal biopsy showed an acute thrombotic microangiopathy consistent with scleroderma renal crisis (SRC). She failed to respond to corticosteroids, plasmapheresis and renin–angiotensin pathway inhibitors. She recovered quickly with the anti-C5 antibody, eculizumab. She had no genetic abnormalities associated with atypica...
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Thomas, C. P., Nester, C. M., Phan, A. C., Sharma, M., Steele, A. L., Lenert, P. S. Tags: THROMBOTIC MICROANGIOPATHY Source Type: research
New combined CFH/MCP mutations and a rare clinical course in atypical haemolytic uraemic syndrome
In this report, we discuss the case of a heterozygous carrier of a mutation on both factor H and membrane cofactor protein, who persistently presents haemolytic anaemia without need for blood transfusions, normal platelet count, normal renal function and no signs or symptoms of organ injury due to thrombotic microangiopathy 4 years after the diagnosis of aHUS. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Lopes, D., Gomes, A. M., Cunha, C., Pinto, C. S., Fidalgo, T., Fernandes, J. C. Tags: THROMBOTIC MICROANGIOPATHY Source Type: research
A COL4A5 mutation with glomerular disease and signs of chronic thrombotic microangiopathy
COL4A5 mutations are a known cause of Alport syndrome, which typically manifests with haematuria, hearing loss and ocular symptoms. Here we report on a 16-year-old male patient with a negative family history who presented with proteinuria, progressive renal failure and haemolysis, but without overt haematuria or hearing loss. A renal biopsy revealed features of atypical IgA nephropathy, while a second biopsy a year later showed features of focal segmental glomerulosclerosis, but was finally diagnosed as chronic thrombotic microangiopathy. Targeted sequencing of candidate genes for steroid-resistant nephrotic syndrome and c...
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Wuttke, M., Seidl, M., Malinoc, A., Prischl, F. C., Kuehn, E. W., Walz, G., Kottgen, A. Tags: THROMBOTIC MICROANGIOPATHY Source Type: research
Thrombotic microangiopathy: expanding genetic, clinical and therapeutic spectra and the need for worldwide implementation of recent advances
In this issue of CKJ, four reports address different aspects of a rare condition, thrombotic microangiopathy, including atypical haemolytic uraemic syndrome. For rare diseases, a single case report may provide hypothesis-generating information that may lead to concept-changing research with the potential to influence patient care. The present reports and small series illustrate the following aspects of thrombotic microangiopathy: (i) the role of whole-exome sequencing and of repeating the family history assessment over time in reducing the number of chronic kidney disease patients with non-specific diagnosis (e.g. focal se...
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Sanchez-Nino, M. D., Ortiz, A. Tags: THROMBOTIC MICROANGIOPATHY Source Type: research
Dengue-associated acute kidney injury
Dengue is presently the most relevant viral infection transmitted by a mosquito bite that represents a major threat to public health worldwide. Acute kidney injury (AKI) is a serious and potentially lethal complication of this disease, and the actual incidence is unknown. In this review, we will assess the most relevant epidemiological and clinical data regarding dengue and the available evidence on the frequency, etiopathogenesis, outcomes and treatment of dengue-associated AKI. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Oliveira, J. F. P., Burdmann, E. A. Tags: AKI Source Type: research
Acute kidney injury risk assessment at the hospital front door: what is the best measure of risk?
Conclusions
Detailed assessment of well-established patient-associated AKI risk factors may not facilitate clinicians to apportion risk. This suggests that additional work is required to develop a more sensitive validated AKI-predictive tool that would be useful in this clinical setting. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Roberts, G., Phillips, D., McCarthy, R., Bolusani, H., Mizen, P., Hassan, M., Hooper, R., Saddler, K., Hu, M., Lodhi, S., Toynton, E., Geen, J., Lodhi, V., Grose, C., Phillips, A. Tags: AKI Source Type: research
Proteomics and mass spectrometry in the diagnosis of renal amyloidosis
The amyloidoses are a ‘group’ of disorders, all of which are associated with deposits that display similar staining and ultrastructural features and are toxic to tissues. Many proteins—currently 31 protein types and many more variants—have been shown to undergo such transformations. Among the various currently known amyloidoses, there are marked differences with regard to their pathogenesis and incidence, while the associated clinical picture is frequently overlapping. However, the therapies that are currently available are amyloid-type specific. The diagnosis of amyloidosis thus involves two steps:...
Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Picken, M. M. Tags: RARE DISEASES Source Type: research
