Treatment with rituximab in idiopathic membranous nephropathy
Conclusions
The present study confirmed that treatment with rituximab was remarkably safe and allowed for a large percentage of complete or partial remissions in patients with MN. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - December 16, 2016 Category: Urology & Nephrology Authors: Fiorentino, M., Tondolo, F., Bruno, F., Infante, B., Grandaliano, G., Gesualdo, L., Manno, C. Tags: GLOMERULOPATHIES Source Type: research
Consequences of morbid obesity on the kidney. Where are we going?
Obesity and morbid obesity are modifiable risk factors for the development and progression of kidney disease. Obesity has reached epidemic proportions and is currently an important health problem in Europe, so it is necessary to develop therapeutic and preventive strategies. The obesity-related glomerulopathy has been defined as a secondary form of focal segmental glomerulosclerosis, and its most characteristic feature is glomerulomegaly. The renal evolution of patients with obesity-related glomerulopathy (ORG) who have not been treated is unfavourable. However, morbidly obese patients with ORG that underwent bariatric sur...
Source: CKJ: Clinical Kidney Journal - December 16, 2016 Category: Urology & Nephrology Authors: Navarro Diaz, M. Tags: SYSTEMIC DISEASE AND THE KIDNEY Source Type: research
HIV and kidney diseases: 35 years of history and consequences
Kidney diseases in human immunodeficiency virus (HIV)-infected patients are often misdiagnosed. Despite reductions in morbidity and mortality owing to widespread use of highly effective combination antiretroviral therapy (cART), acute kidney injury (AKI) and chronic kidney disease (CKD) are still more common in these patients than in the general population, and are associated with poor health outcomes. HIV-associated nephropathy and HIV immune complex kidney diseases are the more recognizable HIV-related kidney diseases. However, a broad spectrum of kidney disorders related or not directly related with HIV infection can be...
Source: CKJ: Clinical Kidney Journal - December 16, 2016 Category: Urology & Nephrology Authors: Campos, P., Ortiz, A., Soto, K. Tags: SYSTEMIC DISEASE AND THE KIDNEY Source Type: research
Macrophage in chronic kidney disease
Chronic kidney disease (CKD) has become a major health problem worldwide. This review describes the role of macrophages in CKD and highlights the importance of anti-inflammatory M2 macrophage activation in both renal fibrosis and wound healing processes. Furthermore, the mechanisms by which M2 macrophages induce renal repair and regeneration are still under debate and currently demand more attention. The M1/M2 macrophage balance is related to the renal microenvironment and could influence CKD progression. In fact, an inflammatory renal environment and M2 plasticity can be the major hurdles to establishing macrophage cell-b...
Source: CKJ: Clinical Kidney Journal - December 16, 2016 Category: Urology & Nephrology Authors: Guiteras, R., Flaquer, M., Cruzado, J. M. Tags: TRANSLATIONAL NEPHROLOGY Source Type: research
Announcements
(Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - September 25, 2016 Category: Urology & Nephrology Tags: ANNOUNCEMENTS Source Type: research
Applying effective teaching and learning techniques to nephrology education
The interest in nephrology as a career has declined over the last several years. Some of the reasons cited for this decline include the complexity of the specialty, poor mentoring and inadequate teaching of nephrology from medical school through residency. The purpose of this article is to introduce the reader to advances in the science of adult learning, illustrate best teaching practices in medical education that can be extrapolated to nephrology and introduce the basic teaching methods that can be used on the wards, in clinics and in the classroom. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - September 25, 2016 Category: Urology & Nephrology Authors: Rondon-Berrios, H., Johnston, J. R. Tags: MANAGEMENT AND EDUCATION TOOLS Source Type: research
RENEW--a renal redesign project in predialysis patient care
Conclusion
Change management strategies with successful implementation are vital components of evolving clinical practice to achieve both clinical and organizational goals. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - September 25, 2016 Category: Urology & Nephrology Authors: Sau Fan Chow, J., Jobburn, K., Chapman, M., Suranyi, M. Tags: MANAGEMENT AND EDUCATION TOOLS Source Type: research
FAbry STabilization indEX (FASTEX): an innovative tool for the assessment of clinical stabilization in Fabry disease
Two disease severity scoring systems, the Mainz Severity Score Index (MSSI) and Fabry Disease Severity Scoring System (DS3), have been validated for quantifying the disease burden of Fabry disease. We aimed to develop a dynamic mathematical model [the FASTEX (FAbry STabilization indEX)] to assess the clinical stability. A multidisciplinary panel of experts in Fabry disease first defined a novel score of severity [raw score (RS)] based on three domains with a small number items in each domain (nervous system domain: pain, cerebrovascular events; renal domain: proteinuria, glomerular filtration rate; cardiac domain: echocard...
Source: CKJ: Clinical Kidney Journal - September 25, 2016 Category: Urology & Nephrology Authors: Mignani, R., Pieruzzi, F., Berri, F., Burlina, A., Chinea, B., Gallieni, M., Pieroni, M., Salviati, A., Spada, M. Tags: MANAGEMENT AND EDUCATION TOOLS Source Type: research
Cutaneous Mycobacterium chelonae infection distal to the arteriovenous fistula
We report three additional cases that share peculiar clinical characteristics, pointing to diagnostic clues. All three cases presented as erythematous nodules developing distally to a proximal arteriovenous fistula (AVF). This presentation was identical to that of two published cases. A survey of all Belgian haemodialysis units during the period 2007–11 yields an estimated incidence of ~0.9/10 000 patient-years. Although the source of M. chelonae remains unclear, this specific clinical presentation should be added to the listing of potential complications of an AVF and should be recognized, as it is fully treatable i...
Source: CKJ: Clinical Kidney Journal - September 25, 2016 Category: Urology & Nephrology Authors: Van Ende, C., Wilmes, D., Lecouvet, F. E., Labriola, L., Cuvelier, R., Van Ingelgem, G., Jadoul, M. Tags: VASCULAR ACCESS Source Type: research
The impact of haemodialysis arteriovenous fistula on haemodynamic parameters of the cardiovascular system
Conclusions
Our observational cross-sectional study describes statistically significant haemodynamic modifications of the CV system associated to an AVF. Moreover, a quadratic polynomial regression model best fits the relationship between LLVAVF and Qa, but only in lower arm AVFs. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - September 25, 2016 Category: Urology & Nephrology Authors: Basile, C., Vernaglione, L., Casucci, F., Libutti, P., Lisi, P., Rossi, L., Vigo, V., Lomonte, C. Tags: VASCULAR ACCESS Source Type: research
Comparison of trends in colorectal cancer screening in the US end-stage renal disease population and the US Medicare population
Conclusions
Given improved survival among hemodialysis patients in the last decade, the utility of colorectal cancer screening even among non-wait-listed hemodialysis patients should be reassessed. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - September 25, 2016 Category: Urology & Nephrology Authors: Fwu, C.-W., Kimmel, P. L., Eggers, P. W., Abbott, K. C. Tags: ONCONEPHROLOGY Source Type: research
Approach to atherosclerotic renovascular disease: 2016
The management of atherosclerotic renal artery stenosis in patients with hypertension or impaired renal function remains a clinical dilemma. The current general consensus, supported by the results of the Angioplasty and Stenting for Renal Atherosclerotic Lesions and Cardiovascular Outcomes for Renal Artery Lesions trials, argues strongly against endovascular intervention in favor of optimal medical management. We discuss the limitations and implications of the contemporary clinical trials and present our approach and formulate clear recommendations to help with the management of patients with atherosclerotic narrowing of t...
Source: CKJ: Clinical Kidney Journal - September 25, 2016 Category: Urology & Nephrology Authors: Daloul, R., Morrison, A. R. Tags: CARDIOVASCULAR DISEASE AND CKD Source Type: research
Cardiovascular-renal complications and the possible role of plasminogen activator inhibitor: a review
Since angiotensin increases the expression of plasminogen activator inhibitor (PAI), mechanisms associated with an actively functioning renin–angiotensin–aldosterone system can be expected to be associated with increased PAI-1 expression. These mechanisms are present not only in common conditions resulting in glomerulosclerosis associated with aging, diabetes or genetic mutations, but also in autoimmune disease (like scleroderma and lupus), radiation injury, cyclosporine toxicity, allograft nephropathy and ureteral obstruction. While the renin–angiotensin–aldosterone system and growth factors, such ...
Source: CKJ: Clinical Kidney Journal - September 25, 2016 Category: Urology & Nephrology Authors: D'Elia, J. A., Bayliss, G., Gleason, R. E., Weinrauch, L. A. Tags: CARDIOVASCULAR DISEASE AND CKD Source Type: research
Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 2: Why to measure glomerular filtration rate with iohexol?
A reliable assessment of glomerular filtration rate (GFR) is of paramount importance in clinical practice as well as epidemiological and clinical research settings. It is recommended by Kidney Disease: Improving Global Outcomes guidelines in specific populations (anorectic, cirrhotic, obese, renal and non-renal transplant patients) where estimation equations are unreliable. Measured GFR is the only valuable test to confirm or confute the status of chronic kidney disease (CKD), to evaluate the slope of renal function decay over time, to assess the suitability of living kidney donors and for dosing of potentially toxic medic...
Source: CKJ: Clinical Kidney Journal - September 25, 2016 Category: Urology & Nephrology Authors: Delanaye, P., Melsom, T., Ebert, N., Bäck, S.-E., Mariat, C., Cavalier, E., Björk, J., Christensson, A., Nyman, U., Porrini, E., Remuzzi, G., Ruggenenti, P., Schaeffner, E., Soveri, I., Sterner, G., Eriksen, B. O., Gaspari, F. Tags: MEASURING GFR Source Type: research
Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 1: How to measure glomerular filtration rate with iohexol?
In conclusion, plasma clearance of iohexol may well be the best candidate for a common GFR determination method. (Source: CKJ: Clinical Kidney Journal)
Source: CKJ: Clinical Kidney Journal - September 25, 2016 Category: Urology & Nephrology Authors: Delanaye, P., Ebert, N., Melsom, T., Gaspari, F., Mariat, C., Cavalier, E., Björk, J., Christensson, A., Nyman, U., Porrini, E., Remuzzi, G., Ruggenenti, P., Schaeffner, E., Soveri, I., Sterner, G., Eriksen, B. O., Bäck, S.-E. Tags: MEASURING GFR Source Type: research
