Treatment of amitriptyline intoxications by extended high cut-off dialysis

We report two cases of amitriptyline poisoning in which we measured the amitriptyline elimination using extended high cut-off (HCO) dialysis. Despite dialyser clearances of 33 and 58 mL/min, resulting in the reduction of initial serum concentrations by ~30%, only 211 and 920 µg of amitryptilin, respectively, (<3% of the ingested amount) could be recovered in the total collected dialysate. Hence, due to the high volume of distribution of amitriptyline, even HCO dialysis does not contribute substantially to the extracorporeal removal of amitryptilin.

Source: CKJ: Clinical Kidney Journal - November 20, 2015 Category: Urology & Nephrology Authors: Schmidt, J. J., Bertram, A., Kuhn-Velten, W. N., Suhling, H., Wiesner, O., Schneider, A., Kielstein, J. T. Tags: DIALYSIS Source Type: research