Pneumococcal hemolytic uremic syndrome and steroid resistant nephrotic syndrome

We report the case of a 12-year-old female with steroid-resistant nephrotic syndrome treated with adrenocorticotrophic hormone (H.P. Acthar® Gel), who developed pneumococcal pneumonia and subsequent pHUS. While nephrotic syndrome is a well-known risk factor for invasive pneumococcal disease, this is the first reported case of pHUS in an adolescent patient with nephrotic syndrome, and reveals novel challenges in the diagnosis, treatment and potential prevention of this complication.

Source: CKJ: Clinical Kidney Journal - July 21, 2016 Category: Urology & Nephrology Authors: Groves, A. P., Reich, P., Sigdel, B., Davis, T. K. Tags: THROMBOTIC MICROANGIOPATHY Source Type: research