Pure red cell aplasia induced by epoetin zeta

We report on a 72-year-old patient who developed hypo-proliferative anaemia unresponsive to ESA following the administration of epoetin zeta subcutaneously for 7 months. On the basis of severe isolated hypoplasia of the erythroid line in the bone marrow and high-titre neutralizing anti-erythropoietin antibodies (Ab), a diagnosis of Ab-mediated PRCA was made. Epoetin zeta was discontinued and the patient was given steroids. This was associated with anaemia recovery. To our knowledge this is the first PRCA case related to epoetin zeta.

Source: CKJ: Clinical Kidney Journal - July 21, 2016 Category: Urology & Nephrology Authors: Panichi, V., Ricchiuti, G., Scatena, A., Del Vecchio, L., Locatelli, F. Tags: PURE RED CELL APLASIA Source Type: research