Meningeal transient receptor potential channel M8 activation causes cutaneous facial and hindpaw allodynia in a preclinical rodent model of headache
Conclusions
These data indicate that transient receptor potential channel M8 activation in the meninges produces behaviors in rats that are consistent with migraine and that are sensitive to pharmacological mechanisms known to have efficacy for migraine in humans. The findings suggest that activation of meningeal transient receptor potential channel M8 may contribute to the pain of migraine. (Source: Cephalalgia)
Source: Cephalalgia - January 18, 2016 Category: Neurology Authors: Burgos-Vega, C. C., Ahn, D. D.-U., Bischoff, C., Wang, W., Horne, D., Wang, J., Gavva, N., Dussor, G. Tags: February 2016 36 (2) Original Articles Source Type: research
Intravenous dexketoprofen vs placebo for migraine attack in the emergency department: A randomized, placebo-controlled trial
Conclusion
Intravenous dexketoprofen is superior to placebo in relieving migraine headaches in the ED. It may be a suitable therapy with minimum side effects in patients presenting with a migraine headache to the ED. (Source: Cephalalgia)
Source: Cephalalgia - January 18, 2016 Category: Neurology Authors: Gungor, F., Akyol, K. C., Kesapli, M., Celik, A., Karaca, A., Bozdemir, M. N., Eken, C. Tags: Original Articles Source Type: research
Toward a pragmatic migraine model for drug testing: 1. Cilostazol in healthy volunteers
Conclusion
Despite similarities with migraine headache, cilostazol-induced headache in healthy volunteers does not respond to sumatriptan. (Source: Cephalalgia)
Source: Cephalalgia - January 18, 2016 Category: Neurology Authors: Hansen, E. K., Guo, S., Ashina, M., Olesen, J. Tags: Original Articles Source Type: research
Reversible alterations of the neuronal activity in spontaneous intracranial hypotension
Conclusions
The abnormal activity of the OFCs and MFC that is not originating from the synchronous intrinsic network activity, together with the decreased activity of the central node of the DMN, could lead to cognitive impairment in SIH that is reversible through restoration of the cerebrospinal fluid. (Source: Cephalalgia)
Source: Cephalalgia - January 18, 2016 Category: Neurology Authors: Amemiya, S., Takahashi, K., Mima, T., Yoshioka, N., Miki, S., Ohtomo, K. Tags: February 2016 36 (2) Original Articles Source Type: research
Randomized controlled trial of the CGRP receptor antagonist telcagepant for prevention of headache in women with perimenstrual migraine
Conclusions
Telcagepant 140 mg taken perimenstrually for seven days was generally well tolerated, but was associated with transaminase elevations. Telcagepant did not reduce monthly headache frequency, but did reduce perimenstrual headaches. (Source: Cephalalgia)
Source: Cephalalgia - January 18, 2016 Category: Neurology Authors: Ho, T. W., Ho, A. P., Ge, Y., Assaid, C., Gottwald, R., MacGregor, E. A., Mannix, L. K., van Oosterhout, W. P., Koppenhaver, J., Lines, C., Ferrari, M. D., Michelson, D. Tags: February 2016 36 (2) Original Articles Source Type: research
Increased interictal visual network connectivity in patients with migraine with aura
Conclusions
Our imaging data revealed that patients with migraine with aura exhibit an altered resting-state visual network connectivity. These results support the hypothesis of an extrastriate cortex involvement, centred in the lingual gyrus, a brain region related to mechanisms underlying the initiation and propagation of the migraine aura. This resting-state functional magnetic resonance imaging finding may represent a functional biomarker that could differentiate patients experiencing the aura phenomenon from patients with migraine without aura, even between migraine attacks. (Source: Cephalalgia)
Source: Cephalalgia - January 18, 2016 Category: Neurology Authors: Tedeschi, G., Russo, A., Conte, F., Corbo, D., Caiazzo, G., Giordano, A., Conforti, R., Esposito, F., Tessitore, A. Tags: February 2016 36 (2) Original Articles Source Type: research
The use of the 25 Sprotte needle markedly reduces post-dural puncture headache in routine neurological practice
Conclusion
The use of the 25S needle in diagnostic LP reduces the frequency and severity of PDPH. (Source: Cephalalgia)
Source: Cephalalgia - January 18, 2016 Category: Neurology Authors: Bertolotto, A., Malentacchi, M., Capobianco, M., di Sapio, A., Malucchi, S., Motuzova, Y., Pulizzi, A., Berchialla, P., Sperli, F. Tags: Original Articles Source Type: research
Detoxification in medication-overuse headache, a retrospective controlled follow-up study: Does care by a headache nurse lead to cure?
Conclusion
The support by a headache nurse results in an increased adherence to detoxification. (Source: Cephalalgia)
Source: Cephalalgia - January 18, 2016 Category: Neurology Authors: Pijpers, J., Louter, M., de Bruin, M., van Zwet, E., Zitman, F., Ferrari, M., Terwindt, G. Tags: Original Articles Source Type: research
Intracranial abnormalities and headache: A population-based imaging study (HUNT MRI)
Conclusions
Headache sufferers had increased odds of minor intracranial abnormalities. The increased odds were primarily related to the presence of white matter hyperintensities. (Source: Cephalalgia)
Source: Cephalalgia - January 18, 2016 Category: Neurology Authors: Honningsvag, L.-M., Hagen, K., Haberg, A., Stovner, L. J., Linde, M. Tags: Original Articles Source Type: research
Computerized tomography-guided sphenopalatine ganglion pulsed radiofrequency treatment in 16 patients with refractory cluster headaches: Twelve- to 30-month follow-up evaluations
Conclusion
Our data show that patients with refractory episodic cluster headaches were quickly, effectively and safely relieved from the cluster period after computerized tomography-guided pulsed radiofrequency treatment of sphenopalatine ganglion, suggesting that it may be a therapeutic option if conservative treatments fail. (Source: Cephalalgia)
Source: Cephalalgia - January 18, 2016 Category: Neurology Authors: Fang, L., Jingjing, L., Ying, S., Lan, M., Tao, W., Nan, J. Tags: Original Articles Source Type: research
Telcagepant--almost gone, but not to be forgotten (invited editorial related to Ho et al., 2015)
(Source: Cephalalgia)
Source: Cephalalgia - January 18, 2016 Category: Neurology Authors: Gottschalk, P. C. H. Tags: Editorial Source Type: research
Board Walk - January 2016
(Source: Cephalalgia)
Source: Cephalalgia - December 17, 2015 Category: Neurology Tags: Board Walk Source Type: research
Effective occipital nerve stimulation during pregnancy in a cluster headache patient
(Source: Cephalalgia)
Source: Cephalalgia - December 17, 2015 Category: Neurology Authors: de Coo, I. F., Wilbrink, L. A., Haan, J. Tags: Letter to the Editor Source Type: research
Reversible cerebral vasoconstriction syndrome in the context of recent cerebral venous thrombosis: Report of a case
We report here the case of a 24-year-old woman who presented a reversible cerebral constriction syndrome in the setting of a cerebral venous thrombosis. Cerebral venous thrombosis had developed in her left lateral venous sinus, within the stent placed one year before, in order to treat an idiopathic intracranial hypertension.
Discussion
The co-occurrence of cerebral venous thrombosis and reversible cerebral constriction syndrome in the same patient raises the issue of a potential link between them. We discuss the potential common trigger factors in this case: recent hormonal therapy; intracranial hypotension iatrogenicall...
Source: Cephalalgia - December 17, 2015 Category: Neurology Authors: Bourvis, N., Franc, J., Szatmary, Z., Chabriat, H., Crassard, I., Ducros, A. Tags: Brief Report Source Type: research
Quality of life in primary headache disorders: A review
Conclusion
This narrative review suggests that headache, particularly in its chronic form, has a great impact on HRQoL. Clinical practice should not solely focus on pain alleviation but rather adopt routine assessment of HRQoL. Furthermore, identification and management of associated psychological comorbidities, which can significantly influence HRQoL in headache sufferers, are essential for optimal clinical management. (Source: Cephalalgia)
Source: Cephalalgia - December 17, 2015 Category: Neurology Authors: Abu Bakar, N., Tanprawate, S., Lambru, G., Torkamani, M., Jahanshahi, M., Matharu, M. Tags: Review Source Type: research
