Genetic epidemiology of migraine and depression
We present a narrative review reporting on the current literature.
Results and conclusions
Epidemiological findings indicate that there is a bidirectional relationship between migraine and depression, with one disorder increasing the risk for the other and vice versa, suggesting shared biological mechanisms. Twin and family studies indicate that this bidirectional relationship can be explained, at least partly, by shared underlying genetically determined disease mechanisms. Although no genes have been robustly associated with the aetiology of both migraine and depression, genes from serotonergic, dopaminergic and GABAergi...
Source: Cephalalgia - June 1, 2016 Category: Neurology Authors: Yang, Y., Ligthart, L., Terwindt, G. M., Boomsma, D. I., Rodriguez-Acevedo, A. J., Nyholt, D. R. Tags: Review Articles Source Type: research
Blood gene expression studies in migraine: Potential and caveats
Conclusion
Current evidence suggests peripheral blood is a biologically valid substrate for genetic studies of migraine, and may be used to identify biomarkers and therapeutic pathways. Pilot blood gene expression data confirm that expression profiles significantly differ between migraine case and non-migraine control individuals. (Source: Cephalalgia)
Source: Cephalalgia - June 1, 2016 Category: Neurology Authors: Gerring, Z., Rodriguez-Acevedo, A. J., Powell, J. E., Griffiths, L. R., Montgomery, G. W., Nyholt, D. R. Tags: Review Articles Source Type: research
The migraine-stroke connection: A genetic perspective
Conclusion
A wealth of data supports a genetic link between migraine and vascular disease. Based on growing high-throughput data-sets, new genotyping techniques and in-depth phenotyping, further insights are expected for the future. (Source: Cephalalgia)
Source: Cephalalgia - June 1, 2016 Category: Neurology Authors: Malik, R., Winsvold, B., Auffenberg, E., Dichgans, M., Freilinger, T. Tags: Review Articles Source Type: research
Gene-based pleiotropy across migraine with aura and migraine without aura patient groups
Conclusions
Our results provide novel insight into the likely genes and biological mechanisms that underlie both MA and MO, and when combined with previous data, highlight the neuropeptide FF-amide peptide encoding gene (NPFF) as a novel candidate risk gene for both types of migraine. (Source: Cephalalgia)
Source: Cephalalgia - June 1, 2016 Category: Neurology Authors: Zhao, H., Eising, E., de Vries, B., Vijfhuizen, L. S., for the International Headache Genetics Consortium, Anttila, V., Winsvold, B. S., Kurth, T., Stefansson, H., Kallela, M., Malik, R., Stam, A. H., Ikram, M. A., Ligthart, L., Freilinger, T., Alexander, Tags: Original Articles Source Type: research
Involvement of astrocyte and oligodendrocyte gene sets in migraine
Discussion
Our results show that gene sets containing astrocyte- and oligodendrocyte-related genes are associated with migraine, which is especially true for gene sets involved in protein modification and signal transduction. Observed differences between migraine with aura and migraine without aura indicate that both migraine types, at least in part, seem to have a different genetic background. (Source: Cephalalgia)
Source: Cephalalgia - June 1, 2016 Category: Neurology Authors: Eising, E., de Leeuw, C., Min, J. L., Anttila, V., Verheijen, M. H., Terwindt, G. M., Dichgans, M., Freilinger, T., Kubisch, C., on behalf of the International Headache Genetics Consortium, Ferrari, M. D., Smit, A. B., de Vries, B., Palotie, A., van den M Tags: Original Articles Source Type: research
The influence of genetic constitution on migraine drug responses
Conclusion
We show for the first time an association between genetic constitution and migraine drug response. This is a first step toward future individualized medicine. (Source: Cephalalgia)
Source: Cephalalgia - June 1, 2016 Category: Neurology Authors: Christensen, A. F., Esserlind, A.-L., Werge, T., Stefansson, H., Stefansson, K., Olesen, J. Tags: Original Articles Source Type: research
The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample
Conclusion
Our study supports previously reported findings on the association of several single nucleotide polymorphisms with migraine. It also suggests that the migraine susceptibility loci may be risk factors for severe migraine traits. (Source: Cephalalgia)
Source: Cephalalgia - June 1, 2016 Category: Neurology Authors: Esserlind, A.-L., Christensen, A. F., Steinberg, S., Grarup, N., Pedersen, O., Hansen, T., Werge, T., Hansen, T. F., Husemoen, L. L. N., Linneberg, A., Budtz-Jorgensen, E., Westergaard, M. L., Stefansson, H., Olesen, J. Tags: Original Articles Source Type: research
Systematic re-evaluation of genes from candidate gene association studies in migraine using a large genome-wide association data set
Conclusion
The available migraine GWAS data provide no clear evidence for involvement of the previously reported most promising candidate genes in migraine. (Source: Cephalalgia)
Source: Cephalalgia - June 1, 2016 Category: Neurology Authors: de Vries, B., Anttila, V., Freilinger, T., Wessman, M., Kaunisto, M. A., Kallela, M., Artto, V., Vijfhuizen, L. S., Göbel, H., Dichgans, M., Kubisch, C., Ferrari, M. D., Palotie, A., Terwindt, G. M., van den Maagdenberg, A. M., on behalf of the In Tags: Original Articles Source Type: research
Migraine genetics: New opportunities, new challenges
(Source: Cephalalgia)
Source: Cephalalgia - June 1, 2016 Category: Neurology Authors: van den Maagdenberg, A. M. Tags: Editorial Source Type: research
Vertigo/dizziness in pediatric emergency department: Five years experience
Conclusions
Most cases of vertigo/dizziness in childhood that consist mainly of migraine and syncope are of benign origin. The prompt identification of neurological or cardiological signs or symptoms associated with vertigo in children is mandatory to rule out life-threatening conditions. (Source: Cephalalgia)
Source: Cephalalgia - April 28, 2016 Category: Neurology Authors: Raucci, U., Vanacore, N., Paolino, M. C., Silenzi, R., Mariani, R., Urbano, A., Reale, A., Villa, M. P., Parisi, P. Tags: Brief Reports Source Type: research
Diffuse non-aneurysmal SAH in spontaneous intracranial hypotension: Sequela of ventral CSF leak?
Discussion
The authors suggest that patients with a ventral spinal CSF leak of long duration may be at risk of diffuse non-aneurysmal SAH. (Source: Cephalalgia)
Source: Cephalalgia - April 28, 2016 Category: Neurology Authors: Schievink, W. I., Maya, M. M. Tags: Brief Reports Source Type: research
Prevalence of primary headache disorders diagnosed according to ICHD-3 beta in three different social groups
Conclusion
Headache prevalence was high and differed markedly among the three social groups. It is important that headache epidemiology also focus on socially defined groups in order to target future preventive efforts. (Source: Cephalalgia)
Source: Cephalalgia - April 28, 2016 Category: Neurology Authors: Lebedeva, E. R., Kobzeva, N. R., Gilev, D., Olesen, J. Tags: Original Articles Source Type: research
Lateral inhibition in the somatosensory cortex during and between migraine without aura attacks: Correlations with thalamocortical activity and clinical features
Conclusions
We hypothesize that abnormal migraine cycle-dependent dynamics of connectivity between subcortical and cortical excitation/inhibition networks may contribute to clinical features of MO and recurrence of attacks. (Source: Cephalalgia)
Source: Cephalalgia - April 28, 2016 Category: Neurology Authors: Coppola, G., Bracaglia, M., Di Lenola, D., Iacovelli, E., Di Lorenzo, C., Serrao, M., Evangelista, M., Parisi, V., Schoenen, J., Pierelli, F. Tags: Original Articles Source Type: research
Do interictal microembolic signals play a role in higher cortical dysfunction during migraine aura?
Conclusion
The present findings indicate that HCD and MES are related in patients with migraine with aura. Further research is needed to better understand the exact pathophysiological mechanism. (Source: Cephalalgia)
Source: Cephalalgia - April 28, 2016 Category: Neurology Authors: Petrusic, I., Podgorac, A., Zidverc-Trajkovic, J., Radojicic, A., Jovanovic, Z., Sternic, N. Tags: Original Articles Source Type: research
Systemic and cerebral endothelial dysfunction in chronic migraine. A case-control study with an active comparator
Conclusions
Migraine is associated with systemic and cerebral endothelial dysfunction demonstrated by ultrasound studies and biological markers. The degree of these changes was strongly associated with the severity of migraine. Our data indicate that migraine may be a cerebral disorder with systemic endothelial damage. (Source: Cephalalgia)
Source: Cephalalgia - April 28, 2016 Category: Neurology Authors: Gonzalez-Quintanilla, V., Toriello, M., Palacio, E., Gonzalez-Gay, M. A., Castillo, J., Montes, S., Martinez-Nieto, R., Fernandez, J., Rojo, A., Gutierrez, S., Pons, E., Oterino, A. Tags: Original Articles Source Type: research
