Long, longer, long QT syndrome: what makes the difference?
Listen to the podcast associated with this article, which can also be found at ESC CardioTalk https://www.escardio.org/The-ESC/Whatwe-do/news/ESC-Cardio-Talk (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 19, 2021 Category: Cardiology Source Type: research
Leaders in Cardiovascular Research: Joseph Hill
CirculationHeart failureGlobal healthBasic scienceCardiology (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 19, 2021 Category: Cardiology Source Type: research
Heart failure or heart success?
HFrEFCardiac myosinFerric carboxymaltoseSotagliflozin (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 13, 2021 Category: Cardiology Source Type: research
Three-dimensional unity of engineered heart tissue mimics the heart better than two-dimensional cellular diversity
This editorial refers to ‘Transcriptome analysis of non human primate-induced pluripotent stem cell-derived cardiomyocytes in 2D monolayer culture vs. 3D engineered heart tissue’ by H. Yanget al., pp.2125 –2136. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 12, 2021 Category: Cardiology Source Type: research
From organic and inorganic phosphates to valvular and vascular calcifications
AbstractCalcification of the arterial wall and valves is an important part of the pathophysiological process of peripheral and coronary atherosclerosis, aortic stenosis, ageing, diabetes, and chronic kidney disease. This review aims to better understand how extracellular phosphates and their ability to be retained as calcium phosphates on the extracellular matrix initiate the mineralization process of arteries and valves. In this context, the physiological process of bone mineralization remains a human model for pathological soft tissue mineralization. Soluble (ionized) calcium precipitation occurs on extracellular phospha...
Source: Cardiovascular Research - February 9, 2021 Category: Cardiology Source Type: research
Vascular smooth muscle cells in atherosclerosis: time for a re-assessment
AbstractVascular smooth muscle cells (VSMCs) are key participants in both early and late-stage atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding lesions, but also forming a protective fibrous cap rich in extracellular matrix to cover the ‘necrotic’ core. Hence, VSMCs have been viewed as plaque-stabilizing, and decreased VSMC plaque content—often measured by expression of contractile markers—associated with increased plaque vulnerability. However, the emergence of lineage-tracing and transcriptomic studies has demonstrated th at VSMCs comprise a much larger proportion of athero...
Source: Cardiovascular Research - February 8, 2021 Category: Cardiology Source Type: research
COVID-19, the wake-up call for implementing sex and gender in cardiovascular disease
Cardiovascular diseaseEqualityGenderWomenSex differences (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 7, 2021 Category: Cardiology Source Type: research
Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion
ConclusionsWe propose a novel tethering function of DRP1 beyond its established fission function, with DRP1-mediated ER remodeling likely contributing to ER constriction of mitochondria that drives mitochondrial fission. We report that DRP1-driven remodeling of select ER micro-domains may critically regulate hepatic proteostasis and identify mdivi-1 as a novel small molecule PCSK9 inhibitor. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 1, 2021 Category: Cardiology Source Type: research
NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias
ConclusionThese results demonstrate that the atrial NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmogenesis and establishes a mechanistic link between obesity-induced AF and NLRP3-inflammasome activation. (Source: Cardiovascular Research)
Source: Cardiovascular Research - February 1, 2021 Category: Cardiology Source Type: research
Corrigendum to: Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells
[Cardiovasc Res. 2012;93(1):162-9; doi:10.1093/cvr/cvr282] (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 30, 2021 Category: Cardiology Source Type: research
Truncated YY1 interacts with BASP1 through a 339KLK341 motif in YY1 and suppresses vascular smooth muscle cell growth and intimal hyperplasia after vascular injury
ConclusionThese studies identify a truncated form of YY1 (YY1B) that can interact with BASP1 and inhibit SMC proliferation, migration, and intimal hyperplasia after balloon injury of rat carotid arteries as effectively as full length YY1. We demonstrate the therapeutic potential of YY1B in vascular proliferative disease. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 28, 2021 Category: Cardiology Source Type: research
Influence of p53 in the transition of myotrophin-induced cardiac hypertrophy to heart failure
(Cardiovasc Res 2020;87:524 –534;https://doi.org/10.1093/cvr/cvq068). (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 24, 2021 Category: Cardiology Source Type: research
Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function
AbstractHeart failure —either with reduced or preserved ejection fraction (HFrEF/HFpEF)—is a clinical syndrome of multifactorial and gender-dependent aetiology, indicating the insufficiency of the heart to pump blood adequately to maintain blood flow to meet the body’s needs. Typical symptoms commonly include short ness of breath, excessive fatigue with impaired exercise capacity, and peripheral oedema, thereby alluding to the fact that heart failure is a syndrome that affects multiple organ systems. Patients suffering from progressed heart failure have a very limited life expectancy, lower than that of numero us can...
Source: Cardiovascular Research - January 23, 2021 Category: Cardiology Source Type: research
An update on the roles of immune system-derived microRNAs in cardiovascular diseases
AbstractCardiovascular diseases (CVD) are a leading cause of human death worldwide. Over the past two decades, the emerging field of cardioimmunology has demonstrated how cells of the immune system play vital roles in the pathogenesis of CVD. MicroRNAs (miRNAs) are critical regulators of cellular identity and function. Cell-intrinsic, as well as cell-extrinsic, roles of immune and inflammatory cell-derived miRNAs have been, and continue to be, extensively studied. Several ‘immuno-miRNAs’ appear to be specifically expressed or demonstrate greatly enriched expression within leucocytes. Identification of miRNAs as critica...
Source: Cardiovascular Research - January 23, 2021 Category: Cardiology Source Type: research
Kcnk3 dysfunction exaggerates the development of pulmonary hypertension induced by left ventricular pressure overload
ConclusionsOur results indicate thatKcnk3-LOF is a key event in the pathobiology of PH due to AAC, suggesting that Kcnk3 channel dysfunction could play a potential key role in the development of PH due to LHD. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 23, 2021 Category: Cardiology Source Type: research
