Inducibility, but not stability, of atrial fibrillation is increased by NOX2 overexpression in mice
ConclusionTogether, these data indicate that while atrial NOX2 overexpression may contribute to atrial arrhythmogenesis, NOX2-derived superoxide production does not affect the electrical and structural properties of the atrial myocardium. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 23, 2021 Category: Cardiology Source Type: research
The key contribution of platelet and vascular arachidonic acid metabolism to the pathophysiology of atherothrombosis
AbstractArachidonic acid is one of the most abundant and ubiquitous ω-6 polyunsaturated fatty acid, present in esterified form in the membrane phospholipids of all mammalian cells and released from phospholipids by several phospholipases in response to various activating or inhibitory stimuli. Arachidonic acid is the precursor of a large number of enzymatically and non-enzymatically derived, biologically active autacoids, including prostaglandins (PGs), thromboxane (TX) A2, leukotrienes, and epoxyeicosatetraenoic acids (collectively called eicosanoids), endocannabinoids and isoprostanes, respectively. Eicosanoids are loca...
Source: Cardiovascular Research - January 23, 2021 Category: Cardiology Source Type: research
Ultrasound-guided catheter implantation improves conscious radiotelemetric blood pressure measurement in mice
(Source: Cardiovascular Research)
Source: Cardiovascular Research - January 23, 2021 Category: Cardiology Source Type: research
AAV-mediated AP-1 decoy oligonucleotide expression inhibits aortic elastolysis in a mouse model of Marfan syndrome
ConclusionThis novel approach protects from deterioration of aortic stability by sustained delivery of nucleic acids-based therapeutics and further elucidated how to interfere with the mechanism of elastolysis. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 20, 2021 Category: Cardiology Source Type: research
Endothelin in diabetes-associated atherosclerosis: opportunity ‘NOX’
This editorial refers to ‘Endothelium-restricted endothelin-1overexpression in type 1 diabetes worsens atherosclerosis and immune cell infiltration via NOX1’ by S. Ouerdet al., pp.1144 –1153. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 20, 2021 Category: Cardiology Source Type: research
Haemodynamics of atherosclerosis: a matter of higher hydrostatic pressure or lower shear stress?
AtherosclerosisHaemodynamicsHydrostatic pressureShear stressBlood flow (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 19, 2021 Category: Cardiology Source Type: research
Sleep deficiency and mortality: is the solution in the gut?
Sleep deficiencyOxidative stressAntioxidantIntestinesCardiovascular disease (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 18, 2021 Category: Cardiology Source Type: research
To serve and protect: a new heart patrolling and recycling role for macrophages
MacrophagesCardiomyocyteExtracellular vesiclesExophereAutophagy (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 18, 2021 Category: Cardiology Source Type: research
Atrial fibrillation after cardiac surgery: to screen or not to screen?
Atrial fibrillation (AF) is diagnosed in 20 –40% of patients in the first week after cardiac surgery and is largely self-limiting, with the majority of patients being discharged from hospital in sinus rhythm (SR). However, that is not the end of it. The rate of subsequent AF development is higher in cardiac surgery patients who experience A F during hospital admission compared to those who do not1; patients with postoperative AF also have a longer hospital stay, a higher long-term risk of stroke (both ischaemic and haemorrhagic) and worse overall prognosis.1 –5 (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 18, 2021 Category: Cardiology Source Type: research
Cardiac troponin and defining myocardial infarction
AbstractThe 4th Universal Definition of Myocardial Infarction has stimulated considerable debate since its publication in 2018. The intention was to define the types of myocardial injury through the lens of their underpinning pathophysiology. In this review, we discuss how the 4th Universal Definition of Myocardial Infarction defines infarction and injury and the necessary pragmatic adjustments that appear in clinical guidelines to maximize triage of real-world patients. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 17, 2021 Category: Cardiology Source Type: research
Connecting the dots? Rate control, heart failure, and atrial fibrillation
This editorial refers to ‘Role of atrial arrhythmia and ventricular response in atrial fibrillation induced atrial remodelling’ by J-B Guichardet al., pp. 462 –471. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 17, 2021 Category: Cardiology Source Type: research
SCORED and SOLOIST: the next scores for SGLT2 inhibitors
heart failurediabetesSGLT2clinical trialskidney disease (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 13, 2021 Category: Cardiology Source Type: research
Highlights of American Heart Association Scientific Sessions 2020: a virtual experience
American Heart AssociationClinical trialsCardiovascular medicineTranslational researchCOVID-19 (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 10, 2021 Category: Cardiology Source Type: research
Approaches to treat pulmonary arterial hypertension by targeting BMPR2: from cell membrane to nucleus
AbstractPulmonary arterial hypertension (PAH) is estimated to affect between 10 and 50 people per million worldwide. The lack of cure and devastating nature of the disease means that treatment is crucial to arrest rapid clinical worsening. Current therapies are limited by their focus on inhibiting residual vasoconstriction rather than targeting key regulators of the cellular pathology. Potential disease-modifying therapies may come from research directed towards causal pathways involved in the cellular and molecular mechanisms of disease. It is widely acknowledged that targeting reduced expression of the critical bone morp...
Source: Cardiovascular Research - January 5, 2021 Category: Cardiology Source Type: research
PTGIR, a susceptibility gene for fibromuscular dysplasia?
This editorial refers to ‘Rare loss-of-function mutations of PTGIR are enriched in fibromuscular dysplasia’ by A. Georgeset al., pp.1154 –1165. (Source: Cardiovascular Research)
Source: Cardiovascular Research - January 4, 2021 Category: Cardiology Source Type: research
