Oxidative stress: a bystander or a causal contributor to atrial remodelling and fibrillation?
NIH10.13039/100000002R01HL136389R01HL131517R01HL089598R01HL104025R01HL106592German Research FoundationDo 769/4-1EU10.13039/100016077965286 (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 2, 2021 Category: Cardiology Source Type: research
Editor ’s Note: RhoA activation and interaction with Caveolin-1 are critical for pressure-induced myogenic tone in rat mesenteric resistance arteries [Cardiovasc Res 2007;73:190-197]
https://doi.org/10.1016/j.cardiores.2006.10.020 (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 1, 2021 Category: Cardiology Source Type: research
Platelets, coagulation, and the vascular wall: the quest to better understand and smarten up our therapeutic targeting of this triad in primary and secondary prevention of cardiovascular events
This editorial refers to ‘The key contribution of platelet and vascular arachidonic acid metabolism to the pathophysiology of atherothrombosis’ by L. Badimonet al., pp. 2001 –2015; ‘Pleiotropic actions of factor Xa inhibition in cardiovascular prevention—mechanistic insights and implications for anti-thrombotic treatment’ by H. ten Cateet al., pp. 2030 –2044; ‘From organic and inorganic phosphates to valvular and vascular calcifications’ by M. Backet al., pp.2016 –2029. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 1, 2021 Category: Cardiology Source Type: research
You ‘heart’ what you eat!
Principal InvestigatorsWELBIO Institute (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 27, 2021 Category: Cardiology Source Type: research
Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it
AbstractAtrial fibrillation (AF) is the most common sustained clinical arrhythmia, with a lifetime incidence of up to 37%, and is a major contributor to population morbidity and mortality. Important components of AF management include control of cardiac rhythm, rate, and thromboembolic risk. In this narrative review article, we focus on rhythm-control therapy. The available therapies for cardiac rhythm control include antiarrhythmic drugs and catheter-based ablation procedures; both of these are presently neither optimally effective nor safe. In order to develop improved treatment options, it is necessary to use preclinica...
Source: Cardiovascular Research - March 25, 2021 Category: Cardiology Source Type: research
Fortified Tregs to fight atherosclerosis
This editorial refers to ‘Adoptive transfer of CX3CR1 transduced-T regulatory cells improves homing to the atherosclerotic plaques and dampens atherosclerosis progression’ by F. Bonacinaet al., pp.2069 –2082. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 21, 2021 Category: Cardiology Source Type: research
The year in basic vascular biology research: from mechanoreceptors and neutrophil extracellular traps to smartphone data and omics
Abstract2020 has been an extraordinary year. The emergence of COVID-19 has driven urgent research in pulmonary and cardiovascular science and other fields. It has also shaped the way that we work with many experimental laboratories shutting down for several months, while bioinformatics approaches and other large data projects have gained prominence. Despite these setbacks, vascular biology research is stronger than ever. On behalf of the European Societyof Cardiology Council for Basic Cardiovascular Science (ESC CBCS), here we review some of the vascular biology research highlights for 2020. This review is not exhaustive a...
Source: Cardiovascular Research - March 21, 2021 Category: Cardiology Source Type: research
Novel approaches to mechanism-based atrial fibrillation ablation
AbstractModern cardiac electrophysiology has reported significant advances in the understanding of mechanisms underlying complex wave propagation patterns during atrial fibrillation (AF), although disagreements remain. One school of thought adheres to the long-held postulate that AF is the result of randomly propagating wavelets that wonder throughout the atria. Another school supports the notion that AF is deterministic in that it depends on a small number of high-frequency rotors generating three-dimensional scroll waves that propagate throughout the atria. The spiralling waves are thought to interact with anatomic and f...
Source: Cardiovascular Research - March 21, 2021 Category: Cardiology Source Type: research
Understanding the role of Iroquois homeobox transcription factor 5 (IRX5) in cardiac function: getting to the (human) heart of the matter
This editorial refers to ‘Human model of IRX5 mutations reveals key role for this transcription factor in ventricular conduction’ by Z.R. Al Sayedet al., pp.2092 –2107. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 19, 2021 Category: Cardiology Source Type: research
Current trends in the use of machine learning for diagnostics and/or risk stratification in cardiovascular disease
Artificial intelligenceMachine learningImagingRiskDeep-learning (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 18, 2021 Category: Cardiology Source Type: research
New aspects of endocrine control of atrial fibrillation and possibilities for clinical translation
AbstractHormones are potent endo-, para-, and autocrine endogenous regulators of the function of multiple organs, including the heart. Endocrine dysfunction promotes a number of cardiovascular diseases, including atrial fibrillation (AF). While the heart is a target for endocrine regulation, it is also an active endocrine organ itself, secreting a number of important bioactive hormones that convey significant endocrine effects, but also through para-/autocrine actions, actively participate in cardiac self-regulation. The hormones regulating heart-function work in concert to support myocardial performance. AF is a serious c...
Source: Cardiovascular Research - March 16, 2021 Category: Cardiology Source Type: research
Single-cell transcriptomics as a building block for determining mechanistic insight of abdominal aortic aneurysm formation
This editorial refers to ‘Single-cell RNA sequencing reveals the cellular heterogeneity of aneurysmal infrarenal abdominal aorta’ by G. Zhaoet al., pp.1402 –1416. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 16, 2021 Category: Cardiology Source Type: research
Jumping on base editing to repair the diseased cardiovascular system in vivo
Genome editingBase editingHutchinson –Gilford progeria syndromeGene therapyVascular smooth muscle (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 16, 2021 Category: Cardiology Source Type: research
Arterial lymphangiogenesis ReSPONDINg 2 a new cue: the R-spondin2/LRG4 axis limits VEGFR3-mediated lymphangiogenesis and reverse cholesterol transport
This editorial refers to ‘Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis’ by B. Singlaet al., pp.1489 –1509. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 13, 2021 Category: Cardiology Source Type: research
Flow, pressure, anatomy: an eternal golden braid
This editorial refers to ‘A novel method for measuring absolute coronary blood flow& microvascular resistance in patients with ischaemic heart disease ’ by P.D. Morriset al., pp.1567 –1577. (Source: Cardiovascular Research)
Source: Cardiovascular Research - March 13, 2021 Category: Cardiology Source Type: research
