Angiopoietin-1 enhanced myocyte mitosis, engraftment, and the reparability of hiPSC-CMs for treatment of myocardial infarction
ConclusionTransient over-expression of Ang-1 enhanced hiPSC-aCM mitosis and engraftment and increased the reparability potency of hiPSC-aCMs for treatment of MI. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 14, 2020 Category: Cardiology Source Type: research
A novel method for measuring absolute coronary blood flow and microvascular resistance in patients with ischaemic heart disease
ConclusionsAbsolute coronary flow and MVR can be determined alongside FFR, in absolute units, during routine catheter laboratory assessment, without the need for additional catheters, wires or drug infusions. Using this novel method, epicardial and microvascular disease can be discriminated and quantified. This comprehensive coronary physiological assessment may enable a new level of patient stratification and management. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 14, 2020 Category: Cardiology Source Type: research
Amber alert: getting to the heart of succinate efflux in reperfusion injury
This editorial refers to ‘Mechanism of succinate efflux upon reperfusion of the ischaemic heart’ by H.A. Praget al., pp.1188 –1201. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 14, 2020 Category: Cardiology Source Type: research
Inflammation and cardiovascular diseases: lessons from seminal clinical trials
AbstractInflammation has been long regarded as a key contributor to atherosclerosis. Inflammatory cells and soluble mediators play critical roles throughout arterial plaque development and accordingly, targeting inflammatory pathways effectively reduces atherosclerotic burden in animal models of cardiovascular (CV) diseases. Yet, clinical translation often led to inconclusive or even contradictory results. The Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) followed by the Colchicine Cardiovascular Outcomes Trial (COLCOT) were the first two randomized clinical trials to convincingly demonstrate the effectiv...
Source: Cardiovascular Research - July 14, 2020 Category: Cardiology Source Type: research
Metabolic inflammation in heart failure with preserved ejection fraction
AbstractOne in 10 persons in the world aged 40 years and older will develop the syndrome of HFpEF (heart failure with preserved ejection fraction), the most common form of chronic cardiovascular disease for which no effective therapies are currently available. Metabolic disturbance and inflammatory burden contribute importantly to HFpEF patho genesis. The interplay within these two biological processes is complex; indeed, it is now becoming clear that the notion of metabolic inflammation—metainflammation—must be considered central to HFpEF pathophysiology. Inflammation and metabolism interact over the course of synd...
Source: Cardiovascular Research - July 14, 2020 Category: Cardiology Source Type: research
A novel signalling mechanism regulating telomere length in cardiomyocytes
This editorial refers to ‘Pim1 maintains telomere length in mouse cardiomyocytes by inhibiting TGFβ signalling’ by D.E. Ebeidet al., pp. 201 –211. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 14, 2020 Category: Cardiology Source Type: research
Classical monocyte transcriptomes reveal significant anti-inflammatory statin effect in women with chronic HIV
ConclusionStatin therapy has been associated with a lower risk of cardiac events, such as myocardial infarction in the general population, but not in those LWH. Our data suggest that women LWH may benefit from statin therapy even in the absence of overt CVD. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 13, 2020 Category: Cardiology Source Type: research
VE-PTP inhibition elicits eNOS phosphorylation to blunt endothelial dysfunction and hypertension in diabetes
ConclusionsVE-PTP inhibition enhances eNOS activity to improve endothelial function and decrease blood pressure indirectly, through the activation of Tie-2 and the CD31/VE-cadherin/VEGFR2 complex, and directly by dephosphorylating eNOS Tyr81. VE-PTP inhibition, therefore, represents an attractive novel therapeutic option for diabetes-induced endothelial dysfunction and hypertension. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 11, 2020 Category: Cardiology Source Type: research
Additive protective effects of sacubitril/valsartan and bosentan on vascular remodelling in experimental pulmonary hypertension
ConclusionDual therapy with LCZ 696 plus bosentan proved significantly superior beneficial effect to LCZ 696 or bosentan alone on vascular remodelling and severity of experimental PH. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 11, 2020 Category: Cardiology Source Type: research
Diet-induced dyslipidemia induces metabolic and migratory adaptations in regulatory T cells
ConclusionAltogether, our findings implicate that dyslipidemia does not contribute to atherosclerosis by impairing Treg cell migration as dyslipidemia associated with an effector-like migratory phenotype in Treg cells. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 11, 2020 Category: Cardiology Source Type: research
Inhibition of MMP prevents doxorubicin-induced cardiotoxicity by attenuating cardiac intracellular and extracellular matrix remodelling
This editorial refers to ‘MMP inhibitors attenuate doxorubicin cardiotoxicity by preventing intracellular and extracellular matrix remodelling’, by B.Y.H. Chanet al., pp. 188 –200. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 10, 2020 Category: Cardiology Source Type: research
Interleukin-7 and interleukin-15 drive CD4+CD28null T lymphocyte expansion and function in patients with acute coronary syndrome
ConclusionOur novel data show that IL-7 and IL-15 drive the expansion and function of CD28null T cells from ACS patients suggesting that IL-7/IL-15 blockade may prevent expansion of these cells and improve patient outcomes. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 9, 2020 Category: Cardiology Source Type: research
The glycocalyx core protein Glypican 1 protects vessel wall endothelial cells from stiffness-mediated dysfunction and disease
ConclusionArterial stiffness promotes EC dysfunction and vascular disease at least partly through the suppression of the glycocalyx protein Glypican 1. Glypican 1 contributes to the protection against endothelial cell dysfunction and vascular disease in endothelial cells. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 9, 2020 Category: Cardiology Source Type: research
Disruption of actin dynamics regulated by Rho effector mDia1 attenuates pressure overload-induced cardiac hypertrophic responses and exacerbates dysfunction
Conclusion mDia1, through actin dynamics, is involved in compensatory cardiac hypertrophy in response to pressure overload. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 9, 2020 Category: Cardiology Source Type: research
β-adrenergic receptors in cardiac muscle: it takes two to tango
This editorial refers to ‘Compartmentalized β1-adrenergic signalling synchronizes excitation –contraction coupling without modulating individual Ca2+ sparks in healthy and hypertrophied cardiomyocytes ’, by H.-Q. Yanget al., pp. 2069 –2080. (Source: Cardiovascular Research)
Source: Cardiovascular Research - July 9, 2020 Category: Cardiology Source Type: research
