Mechanism of ventricular premature beats elicited by left stellate ganglion stimulation during acute ischaemia of the anterior left ventricle
ConclusionLSGS, by virtue of shortening of repolarization in the non-ischaemic myocardium by about 100 ms, causes deeply negative T waves in the ischaemic tissue and VPBs originating from the normal tissue adjacent to the ischaemic border. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 27, 2020 Category: Cardiology Source Type: research
High spatial endothelial shear stress gradient independently predicts site of acute coronary plaque rupture and erosion
ConclusionsHigh ESSG is independently associated with plaque rupture while high ESSG, ESS, and OSI associate with plaque erosion. While ESSG is higher at rupture sites than erosion sites, OSI is higher at erosion sites and ESS was similar. These results suggest that ESSG and OSI may play critical roles in acute plaque rupture and erosion, respectively. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 24, 2020 Category: Cardiology Source Type: research
Autonomic innervation of the carotid body as a determinant of its sensitivity: implications for cardiovascular physiology and pathology
AbstractThe motivation for this review comes from the emerging complexity of the autonomic innervation of the carotid body (CB) and its putative role in regulating chemoreceptor sensitivity. With the carotid bodies as a potential therapeutic target for numerous cardiorespiratory and metabolic diseases, an understanding of the neural control of its circulation is most relevant. Since nerve fibres track blood vessels and receive autonomic innervation, we initiate our review by describing the origins of arterial feed to the CB and its unique vascular architecture and blood flow. Arterial feed(s) vary amongst species and, uneq...
Source: Cardiovascular Research - August 24, 2020 Category: Cardiology Source Type: research
Intracellular NAMPT –NAD+–SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors
[Cardiovasc Res 2014;104:477 –488https://doi.org/10.1093/cvr/cvu220] (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 21, 2020 Category: Cardiology Source Type: research
Impaired cytoplasmic domain interactions cause co-assembly defect and loss of function in the p.Glu293Lys KNCJ2 variant isolated from an Andersen –Tawil syndrome patient
ConclusionsLoss of function and dominant-negative effect confirm the causative role of p.Glu293Lys in ATS1. Co-assembly of Kir2.1 subunits is impaired in homomeric channels consisting of p.Glu293Lys subunits and is partially rescued in heteromeric complexes of WT and p.Glu293Lys Kir2.1 variants. These data point to an important role of Glu293 in mediating subunit assembly, as well as in gating of Kir2.1 channels. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 18, 2020 Category: Cardiology Source Type: research
Preclinical evidence for the therapeutic value of TBX5 normalization in arrhythmia control
Conclusions This study uncovers a novel cardioprotective role of TBX5 in the adult heart and provides preclinical evidence for the therapeutic value of TBX5 protein normalization in the control of arrhythmia. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 10, 2020 Category: Cardiology Source Type: research
Global variations in the prevalence, treatment, and impact of atrial fibrillation in a multi-national cohort of 153 152 middle-aged individuals
ConclusionsLarge variations in AF prevalence occur in different regions and countries grouped by income level, but this is only partially explained by traditional AF risk factors. Antithrombotic therapy is infrequently used in poorer countries despite the high risk of stroke associated with AF. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 10, 2020 Category: Cardiology Source Type: research
Corrigendum to: Functional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates cells via mesenchymal stem cell intermediates
[Cardiovasc Res 2012;96:391 –400https://doi.org/10.1093/cvr/cvs253] (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 9, 2020 Category: Cardiology Source Type: research
Mechanism of succinate efflux upon reperfusion of the ischaemic heart
Conclusion Succinate release upon reperfusion of the ischaemic heart is mediated by MCT1 and is facilitated by the acidification of the myocardium during ischaemia. These findings will allow the signalling interaction between succinate released from reperfused ischaemic myocardium and SUCNR1 to be explored. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 7, 2020 Category: Cardiology Source Type: research
RE: A synthetic peptide from transforming growth factor- β1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats. Cardiovascular Research, Volume 81, Issue 3, 15 February 2009, Pages 601–609. Javier Díez, https://doi.org/10.1093/cvr/cvn315
A reader alerted the Editorial Office on the 14th November 2019 regarding concerns about the data presented in Figures 3 and 5 of the above paper. The authors, in correspondence with the Cardiovascular Research Editorial Office, have confirmed that the samples were randomized to be run on a western blot and then the resulting blots were spliced together for the purposes of figure representation. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 5, 2020 Category: Cardiology Source Type: research
Insights into cardiovascular research in G öttingen and Heidelberg: a report by the ESC Scientists of Tomorrow
Cardiovascular research developmentsLatest insightsHeart failureAtrial fibrillation (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 5, 2020 Category: Cardiology Source Type: research
Impaired retinal microvascular function predicts long-term adverse events in patients with cardiovascular disease
ConclusionRetinal arteriolar endothelial dysfunction is an independent predictor of MACE in patients with CAD or cardiovascular risk factors. Dynamic retinal vessel analysis may provide added benefit to traditional risk factors in stratifying patients at risk for cardiovascular events. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 4, 2020 Category: Cardiology Source Type: research
Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis
ConclusionThese findings demonstrate that RSPO2 inhibits lymphangiogenesis via LGR4 and downstream impairment of AKT-eNOS-nitric oxide signalling. These results may also inform new therapeutic strategies to promote lymphangiogenesis and improve cholesterol efflux from atherosclerotic arteries. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 4, 2020 Category: Cardiology Source Type: research
Hiding in plain sight: an encapsulated approach to cardiac cell therapy
This editorial refers to ‘Sustained subcutaneous delivery of secretome of human cardiac stem cells promotes cardiac repair following myocardial infarction’ by A.R. Kompaet al., pp.918 –929. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 4, 2020 Category: Cardiology Source Type: research
A neurohumoral activation of renin-angiotensin-aldosterone system in endothelial dysfunction modulating immunity in heart failure
This editorial refers to ‘Nox2+ myeloid cells drive vascular inflammation and endothelial dysfunction in heart failure after myocardial infarction via angiotensin II receptor type 1 ’ by M. Molitoret al., pp. 162 –177. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 4, 2020 Category: Cardiology Source Type: research
