Corrigendum to: Heart failure or heart success?
Cardiovascular Research (2021); doi:10.1093/cvr/cvab022 (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 18, 2021 Category: Cardiology Source Type: research
Coping with sterile inflammation: between risk and necessity
MyocardiumImmune systemInflammationMyocardial infarctionDisease tolerance (Source: Cardiovascular Research)
Source: Cardiovascular Research - May 18, 2021 Category: Cardiology Source Type: research
Neuroscientific therapies for atrial fibrillation
AbstractThe cardiac autonomic nervous system (ANS) plays an integral role in normal cardiac physiology as well as in disease states that cause cardiac arrhythmias. The cardiac ANS, comprised of a complex neural hierarchy in a nested series of interacting feedback loops, regulates atrial electrophysiology and is itself susceptible to remodelling by atrial rhythm. In light of the challenges of treating atrial fibrillation (AF) with conventional pharmacologic and myoablative techniques, increasingly interest has begun to focus on targeting the cardiac neuraxis for AF. Strong evidence from animal models and clinical patients d...
Source: Cardiovascular Research - May 14, 2021 Category: Cardiology Source Type: research
Genetics of atrial fibrillation —practical applications for clinical management: if not now, when and how?
AbstractThe prevalence and economic burden of atrial fibrillation (AF) are predicted to more than double over the next few decades. In addition to anticoagulation and treatment of concomitant cardiovascular conditions, early and standardized rhythm control therapy reduces cardiovascular outcomes as compared with a rate control approach, favouring the restoration, and maintenance of sinus rhythm safely. Current therapies for rhythm control of AF include antiarrhythmic drugs (AADs) and catheter ablation (CA). However, response in an individual patient is highly variable with some remaining free of AF for long periods on anti...
Source: Cardiovascular Research - May 12, 2021 Category: Cardiology Source Type: research
How machine learning is impacting research in atrial fibrillation: implications for risk prediction and future management
AbstractThere has been an exponential growth of artificial intelligence (AI) and machine learning (ML) publications aimed at advancing our understanding of atrial fibrillation (AF), which has been mainly driven by the confluence of two factors: the advances in deep neural networks (DeepNNs) and the availability of large, open access databases. It is observed that most of the attention has centred on applying ML for dvsetecting AF, particularly using electrocardiograms (ECGs) as the main data modality. Nearly a third of them used DeepNNs to minimize or eliminate the need for transforming the ECGs to extract features prior t...
Source: Cardiovascular Research - May 12, 2021 Category: Cardiology Source Type: research
From polygenic risk scores to integrative epigenomics: the dawn of a new era for cardiovascular precision medicine
Integrative epigenomicsGenome-wide association study (GWAS)Complex traitsCoronary artery disease (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 29, 2021 Category: Cardiology Source Type: research
VE-PTP inhibition: a novel therapeutic target for hypertension in diabetic patients
This editorial refers to ‘VE-PTP inhibition elicits eNOS phosphorylation to blunt endothelial dysfunction and hypertension in diabetes’ by M. Siragusaet al., pp. 1546 –1556. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 26, 2021 Category: Cardiology Source Type: research
Progress in aorta and peripheral cardiovascular disease research
AbstractAlthough coronavirus disease 2019 seems to be the leading topic in research number of outstanding studies have been published in the field of aorta and peripheral vascular diseases likely affecting our clinical practice in the near future. This review article highlights key research on vascular diseases published in 2020. Some studies have shed light in the pathophysiology of aortic aneurysm and dissection suggesting a potential role for kinase inhibitors as new therapeutic options. A first proteogenomic study on fibromuscular dysplasia (FMD) revealed a promising novel disease gene and provided proof-of-concept for...
Source: Cardiovascular Research - April 23, 2021 Category: Cardiology Source Type: research
Computational models of atrial fibrillation: achievements, challenges, and perspectives for improving clinical care
AbstractDespite significant advances in its detection, understanding and management, atrial fibrillation (AF) remains a highly prevalent cardiac arrhythmia with a major impact on morbidity and mortality of millions of patients. AF results from complex, dynamic interactions between risk factors and comorbidities that induce diverse atrial remodelling processes. Atrial remodelling increases AF vulnerability and persistence, while promoting disease progression. The variability in presentation and wide range of mechanisms involved in initiation, maintenance and progression of AF, as well as its associated adverse outcomes, mak...
Source: Cardiovascular Research - April 23, 2021 Category: Cardiology Source Type: research
Ion channel regulation in endothelial function: the key role of dietary polyunsaturated fatty acids for TRPV4 activity
This editorial refers to ‘Omega-3 polyunsaturated fatty acids improve flow-induced vasodilation by enhancing TRPV4 activity in arteries from diet-induced obese mice’ by Y. Zhuet al., pp.2450 –2458. (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 20, 2021 Category: Cardiology Source Type: research
Revealing the molecular history of the transition from paroxysmal to permanent atrial fibrillation
This editorial refers to ‘Transcriptome and proteome mapping in the sheep atria reveal molecular features of atrial fibrillation progression’ by A. Alvarez-Francoet al., pp.1760 –1775 (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 20, 2021 Category: Cardiology Source Type: research
Avalanching nanoparticles bring new light to cardiovascular imaging
Avalanching nanoparticlesNanoscienceUpconversion nanoparticlesCardiovascular imagingArtificial intelligence (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 20, 2021 Category: Cardiology Source Type: research
A titan of Cardiovascular Research: Professor Peter Sleight (1929 –2020)
Cardiovascular researchCardiologyMemorialAspirinThrombolysis (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 20, 2021 Category: Cardiology Source Type: research
Cardiovascular RNA markers and artificial intelligence may improve COVID-19 outcome: a position paper from the EU-CardioRNA COST Action CA17129
AbstractThe coronavirus disease 2019 (COVID-19) pandemic has been as unprecedented as unexpected, affecting more than 105 million people worldwide as of 8 February 2020 and causing more than 2.3 million deaths according to the World Health Organization (WHO). Not only affecting the lungs but also provoking acute respiratory distress, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is able to infect multiple cell types including cardiac and vascular cells. Hence a significant proportion of infected patients develop cardiac events, such as arrhythmias and heart failure. Patients with cardiovascular comorbidities...
Source: Cardiovascular Research - April 11, 2021 Category: Cardiology Source Type: research
The neurology of hypertension: merging academic specialties to connect heart and brain pathophysiology
HypertensionBrainAutonomic nervous systemImmunityDementia (Source: Cardiovascular Research)
Source: Cardiovascular Research - April 5, 2021 Category: Cardiology Source Type: research
