In This Issue
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 27, 2017 Category: Rheumatology Tags: In This Issue Source Type: research
Issue Information
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 27, 2017 Category: Rheumatology Tags: Issue Information Source Type: research
Understanding the antibody repertoire in Neuropsychiatric Systemic Lupus Erythematosus and Neuromyelitis Optica Spectrum Disorders: do they share common targets?
ConclusionPatients with demyelinating disease should be tested for AQP4‐IgG, MOG‐IgG and DWEYS‐IgG. AQP4–IgG is diagnostic for NMOSD; none of the antibodies is diagnostic for dNPSLE. dsDNA‐IgG are present in NMOSD but are not cross‐reactive with DWEYS, indicating a different antigenic stimulus and potentially different mechanisms of tissue damage.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 26, 2017 Category: Rheumatology Authors: Simone Mader, Venkatesh Jeganathan, Yoshiyuki Arinuma, Yuichiro Fujieda, Irena Dujmovic, Jelena Drulovic, Yuka Shimizu, Yuko Sakuma, Joel N.H. Stern, Cynthia Aranow, Meggan Mackay, Shinsuke Yasuda, Tatsuya Atsumi, Shunsei Hirohata, Betty Diamond Tags: Full Length Source Type: research
Antigen ‐driven lymphoproliferations in Sjögren's Syndrome patients accumulate in complement receptor 2/CD21‐/low B cells
ConclusionClonal lymphoproliferations in SS patients preferentially accumulate in the autoreactive CD21‐/low B cell compartment, which is often amplified in these subjects, and (self)‐antigen recognition may drive expansion while further refining BCR (self)‐reactivity.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 26, 2017 Category: Rheumatology Authors: Salom é Glauzy, Marco Boccitto, Jason M. Bannock, Fabien R. Delmotte, David Saadoun, Patrice Cacoub, John A. Ice, Kathy L. Sivils, Judith A. James, Sandra L. Wolin, Eric Meffre Tags: Full Length Source Type: research
Belimumab for the Treatment of Early Diffuse Systemic Sclerosis: Results of a Randomized, Double ‐Blind, Placebo‐Controlled, Pilot Trial
ConclusionPatients in both treatment groups experienced significant improvements in MRSS. The median difference was greater in the belimumab group but did not achieve statistical significance in this small pilot study. Adverse events were similar between the groups. Changes in gene expression were consistent with mechanism of action and show that clinical response to treatment with belimumab is associated with significant decrease in pro‐fibrotic genes and pathways. Additional studies are needed to determine the role of belimumab in the treatment of dcSSc.This article is protected by copyright. All rights reserved. (Sour...
Source: Arthritis and Rheumatism - October 26, 2017 Category: Rheumatology Authors: Jessica K. Gordon, Viktor Martyanov, Jennifer M. Franks, Elana J. Bernstein, Jackie Szymonifka, Cynthia Magro, Horatio F. Wildman, Tammara A. Wood, Michael L. Whitfield, Robert F. Spiera Tags: Full Length Source Type: research
Gut Microbiota Perturbations in Reactive Arthritis and Post ‐Infectious Spondyloarthritis
ConclusionThis is the first culture‐independent study characterizing the gut microbial community of post‐infectious arthritis. Although bacterial factors correlated with disease presence and clinical features of ReA, host genetics also appeared to be a major independent driver of intestinal community composition. Understanding of these gut microbiota host‐genetic relationships may further clarify the pathogenesis of post‐infectious spondyloarthropathies.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 26, 2017 Category: Rheumatology Authors: Julia Manasson, Nan Shen, Helga R. Garcia Ferrer, Carles Ubeda, Isa Iraheta, Adriana Heguy, Joan M. Von Feldt, Luis R. Espinoza, Abraham Garcia Kutzbach, Leopoldo N. Segal, Alexis Ogdie, Jose C. Clemente, Jose U. Scher Tags: Full Length Source Type: research
Brief Report: Clinical and Molecular Phenotypes of Low ‐Penetrance Variants of NLRP3: Diagnostic and Therapeutic Challenges
ConclusionPatients with low‐penetrance NLRP3 variants display a distinct clinical phenotype and an intermediate biologic phenotype, including IL‐1β and non–IL‐1β–mediated inflammatory pathway activation. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 17, 2017 Category: Rheumatology Authors: J. B. Kuemmerle ‐Deschner, D. Verma, T. Endres, L. Broderick, A. A. Jesus, F. Hofer, N. Blank, K. Krause, C. Rietschel, G. Horneff, I. Aksentijevich, P. Lohse, R. Goldbach‐Mansky, H. M. Hoffman, S. M. Benseler Tags: Brief Report Source Type: research
Brief Report: Association of Natural Killer Cell Ligand Polymorphism HLA –C Asn80Lys With the Development of Anti‐SSA/Ro–Associated Congenital Heart Block
ConclusionThese data establish C2 as a novel genetic risk factor associated with CHB. This observation supports a model in which fetuses with C2 ligand expression and maternal anti‐SSA/Ro positivity may have impaired NK cell surveillance, resulting in unchecked cardiac inflammation and scarring. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 17, 2017 Category: Rheumatology Authors: Hannah C. Ainsworth, Miranda C. Marion, Tiziana Bertero, Antonio Brucato, Rolando Cimaz, Nathalie Costedoat ‐Chalumeau, Micaela Fredi, Patrick Gaffney, Jennifer Kelly, Kateri Levesque, Alice Maltret, Nathalie Morel, Veronique Ramoni, Amelia Ruffatti, Ca Tags: Brief Report Source Type: research
Review: The Evolving Landscape for Complement Therapeutics in Rheumatic and Autoimmune Diseases
The complement system is increasingly understood to play major roles in the pathogenesis of human inflammatory and autoimmune diseases. Because of this situation, there are rapidly expanding commercial efforts to develop novel complement inhibitors and effector pathway–modulating drugs. This review provides insights into the evolving understanding of the complement system components, mechanisms of activation within and across the 3 pathways (classical, alternative, and lectin), how the pathways are normally controlled and then dysregulated in target tissues, and what diseases are known to be, in large part, complement‐...
Source: Arthritis and Rheumatism - October 17, 2017 Category: Rheumatology Authors: Joshua M. Thurman, Ashley Frazer ‐Abel, V. Michael Holers Tags: Review Source Type: research
Editorial: Response to the American College of Physicians Osteoporosis Guideline, 2017 Update
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 17, 2017 Category: Rheumatology Authors: Liron Caplan, Karen E. Hansen, Kenneth G. Saag Tags: Editorial Source Type: research
Clinical and Molecular Phenotypes of Low ‐Penetrance Variants of NLRP3: Diagnostic and Therapeutic Challenges
ConclusionPatients with low‐penetrance NLRP3 variants display a distinct clinical phenotype and an intermediate biologic phenotype, including IL‐1β and non–IL‐1β–mediated inflammatory pathway activation. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 17, 2017 Category: Rheumatology Authors: J. B. Kuemmerle ‐Deschner, D. Verma, T. Endres, L. Broderick, A. A. Jesus, F. Hofer, N. Blank, K. Krause, C. Rietschel, G. Horneff, I. Aksentijevich, P. Lohse, R. Goldbach‐Mansky, H. M. Hoffman, S. M. Benseler Tags: Brief Report Source Type: research
Association of Natural Killer Cell Ligand Polymorphism HLA –C Asn80Lys With the Development of Anti‐SSA/Ro–Associated Congenital Heart Block
ConclusionThese data establish C2 as a novel genetic risk factor associated with CHB. This observation supports a model in which fetuses with C2 ligand expression and maternal anti‐SSA/Ro positivity may have impaired NK cell surveillance, resulting in unchecked cardiac inflammation and scarring. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 17, 2017 Category: Rheumatology Authors: Hannah C. Ainsworth, Miranda C. Marion, Tiziana Bertero, Antonio Brucato, Rolando Cimaz, Nathalie Costedoat ‐Chalumeau, Micaela Fredi, Patrick Gaffney, Jennifer Kelly, Kateri Levesque, Alice Maltret, Nathalie Morel, Veronique Ramoni, Amelia Ruffatti, Ca Tags: Brief Report Source Type: research
Role of Stromelysin 2 (Matrix Metalloproteinase 10) as a Novel Mediator of Vascular Remodeling Underlying Pulmonary Hypertension Associated With Systemic Sclerosis
ConclusionGene expression profiling of EPC‐derived ECs identified MMP10 as a novel candidate gene in SSc‐associated PH. MMP10 is overexpressed in the serum and pulmonary arteries of patients with SSc‐associated PH, and its blockade alleviates PH in the Fra‐2–Tg mouse model. MMP10 appears to be a prospective treatment target for this devastating disorder. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 17, 2017 Category: Rheumatology Authors: J érôme Avouac, Christophe Guignabert, Anna Maria Hoffmann‐Vold, Barbara Ruiz, Peter Dorfmuller, Sonia Pezet, Olivia Amar, Ly Tu, Jérôme Van Wassenhove, Jérémy Sadoine, David Launay, Muriel Elhai, Anne Cauvet, Arun Subramaniam, Robert Resnick, Eri Tags: Original Article Source Type: research
NF ‐κB2 Controls the Migratory Activity of Memory T Cells by Regulating Expression of CXCR4 in a Mouse Model of Sjögren's Syndrome
ConclusionOur results suggest that the RelB/NF‐κB2 pathway regulates T cell migration to autoimmune targets through TGFβ/TGFβR‐dependent regulation of CXCL12/CXCR4 signaling. This suggests that these signaling pathways are potential therapeutic targets for the treatment of autoimmune diseases. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 17, 2017 Category: Rheumatology Authors: Mie Kurosawa, Rieko Arakaki, Akiko Yamada, Takaaki Tsunematsu, Yasusei Kudo, Jonathan Sprent, Naozumi Ishimaru Tags: Original Article Source Type: research
Response to the American College of Physicians Osteoporosis Guideline, 2017 Update
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 17, 2017 Category: Rheumatology Authors: Liron Caplan, Karen E. Hansen, Kenneth G. Saag Tags: Editorial Source Type: research
