Understanding the antibody repertoire in Neuropsychiatric Systemic Lupus Erythematosus and Neuromyelitis Optica Spectrum Disorders: do they share common targets?

ConclusionPatients with demyelinating disease should be tested for AQP4‐IgG, MOG‐IgG and DWEYS‐IgG. AQP4–IgG is diagnostic for NMOSD; none of the antibodies is diagnostic for dNPSLE. dsDNA‐IgG are present in NMOSD but are not cross‐reactive with DWEYS, indicating a different antigenic stimulus and potentially different mechanisms of tissue damage.This article is protected by copyright. All rights reserved.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fart.40356

Source: Arthritis and Rheumatism - October 26, 2017 Category: Rheumatology Authors: Simone Mader, Venkatesh Jeganathan, Yoshiyuki Arinuma, Yuichiro Fujieda, Irena Dujmovic, Jelena Drulovic, Yuka Shimizu, Yuko Sakuma, Joel N.H. Stern, Cynthia Aranow, Meggan Mackay, Shinsuke Yasuda, Tatsuya Atsumi, Shunsei Hirohata, Betty Diamond Tags: Full Length Source Type: research