The Epidemiology of Antineutrophil Cytoplasmic Autoantibody –Associated Vasculitis in Olmsted County, Minnesota
ConclusionThe annual incidence of AAV in Olmsted County, Minnesota over the 20 years of the study was 3.3 per 100,000, with a prevalence of 42.1 per 100,000, which is substantially higher than the rates reported in other areas worldwide. The incidence of GPA was similar to that of MPA. Patients with MPA and those with EGPA, but not patients with GPA, experienced higher rates of mortality than that in the Minnesota general population. MPO‐ANCAs were a marker of poor survival in this population of patients with AAV. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 9, 2017 Category: Rheumatology Authors: Alvise Berti, Divi Cornec, Cynthia S. Crowson, Ulrich Specks, Eric L. Matteson Tags: Original Article Source Type: research
Drugs Implicated in Systemic Autoimmunity Modulate Neutrophil Extracellular Trap Formation
ConclusionMedications commonly implicated in drug‐induced autoimmunity trigger NET formation displaying distinct protein cargo, via common and specific pathways. NETosis may play a role in the pathogenesis of drug‐induced autoimmunity.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 9, 2017 Category: Rheumatology Authors: Jorge A. Irizarry ‐Caro, Carmelo Carmona‐Rivera, Daniella M. Schwartz, Sami S. Khaznadar, Mariana J. Kaplan, Peter C. Grayson Tags: Brief Report Source Type: research
Bench to Bedside – and Back Again: Finding the Goldilocks Zone within the Scleroderma Universe
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 9, 2017 Category: Rheumatology Authors: Janet E. Pope, Jason J Lee, Christopher P. Denton Tags: Editorial Source Type: research
Brief Report: A Novel ELANE Mutation Associated With Inflammatory Arthritis, Defective NETosis, and Recurrent Parvovirus Infection
ConclusionThis is the first report of a human pathogenic ELANE mutation associated with a defect in NETosis and a distinct syndrome of recurrent viral infection and chronic inflammation. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 8, 2017 Category: Rheumatology Authors: Uma Thanarajasingam, Mark A. Jensen, Jessica M. Dorschner, Theresa Wampler Muskardin, Yogita Ghodke ‐Puranik, Monica Purmalek, Elias Eliopoulos, Maria I. Zervou, George N. Goulielmos, Matthew Howard, Mariana J. Kaplan, Timothy B. Niewold Tags: Brief Report Source Type: research
Relapsing polychondritis diagnosed by fusion images of gallium ‐67 uptake on computed tomography and single‐photon–emission computed tomography
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 8, 2017 Category: Rheumatology Authors: Kazuhisa Nakano, Takafumi Aritomi, Naoaki Ohkubo, Yoshiya Tanaka Tags: Clinical Images Source Type: research
Pulmonary sarcoidosis revealed by ulcerating nodules within tattoos
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 8, 2017 Category: Rheumatology Authors: Brandon L. Adler, Gene H. Kim, Alexandra D. Haden Tags: Clinical Images Source Type: research
Brief Report: Drug ‐Free Long‐Term Remission in Severe Behçet's Disease Following Withdrawal of Successful Anti–Tumor Necrosis Factor Treatment
ConclusionDrug‐free, long‐term remission after withdrawal of successful anti‐TNF treatment is feasible in patients with severe BD. Because an anti‐TNF agent–induced “cure” cannot be differentiated from spontaneous remission by natural history, prospective studies should examine whether anti‐TNF agents should be used as first‐line treatment for the induction of remission in every patient with vital organ involvement. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 8, 2017 Category: Rheumatology Authors: Petros P. Sfikakis, Aikaterini Arida, Stylianos Panopoulos, Kalliopi Fragiadaki, George Pentazos, Katerina Laskari, Maria Tektonidou, Nikos Markomichelakis Tags: Brief Report Source Type: research
Review: Metabolic Control of Immune System Activation in Rheumatic Diseases
Metabolic pathways mediate lineage specification within the immune system through the regulation of glucose utilization, a process that generates energy in the form of ATP and synthesis of amino acids, nucleotides, and lipids to enable cell growth, proliferation, and survival. CD4+ T cells, a proinflammatory cell subset, preferentially produce ATP through glycolysis, whereas cells with an antiinflammatory lineage, such as memory and regulatory T cells, favor mitochondrial ATP generation. In conditions of metabolic stress or a shortage of nutrients, cells rely on autophagy to secure amino acids and other substrates, while s...
Source: Arthritis and Rheumatism - November 8, 2017 Category: Rheumatology Authors: Andras Perl Tags: Review Source Type: research
Clinical Images: Relapsing polychondritis diagnosed by fusion images of gallium ‐67 uptake on computed tomography and single‐photon–emission computed tomography
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 8, 2017 Category: Rheumatology Authors: Kazuhisa Nakano, Takafumi Aritomi, Naoaki Ohkubo, Yoshiya Tanaka Tags: Clinical Images Source Type: research
Drug ‐Free Long‐Term Remission in Severe Behçet's Disease Following Withdrawal of Successful Anti–Tumor Necrosis Factor Treatment
ConclusionDrug‐free, long‐term remission after withdrawal of successful anti‐TNF treatment is feasible in patients with severe BD. Because an anti‐TNF agent–induced “cure” cannot be differentiated from spontaneous remission by natural history, prospective studies should examine whether anti‐TNF agents should be used as first‐line treatment for the induction of remission in every patient with vital organ involvement. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 8, 2017 Category: Rheumatology Authors: Petros P. Sfikakis, Aikaterini Arida, Stylianos Panopoulos, Kalliopi Fragiadaki, George Pentazos, Katerina Laskari, Maria Tektonidou, Nikos Markomichelakis Tags: Brief Report Source Type: research
Immortal time bias: comment on the article by Gwinnutt et al
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 8, 2017 Category: Rheumatology Authors: Cynthia S. Crowson Tags: Letters Source Type: research
Reply
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 8, 2017 Category: Rheumatology Authors: Cormac McCarthy, Emer P. Reeves, Carl Orr, Ursula Fearon, Douglas J. Veale, Noel G. McElvaney Tags: Letter Source Type: research
Clinical Images: Pulmonary sarcoidosis revealed by ulcerating nodules within tattoos
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 8, 2017 Category: Rheumatology Authors: Brandon L. Adler, Gene H. Kim, Alexandra D. Haden Tags: Clinical Images Source Type: research
Safety, Tolerability, and Pharmacodynamics of ABT ‐122, a Tumor Necrosis Factor– and Interleukin‐17–Targeted Dual Variable Domain Immunoglobulin, in Patients With Rheumatoid Arthritis
ConclusionThe results of these phase I studies suggest that dual neutralization of TNF and IL‐17 with ABT‐122 has characteristics acceptable for further exploration of therapeutic potential in TNF‐ and IL‐17A–driven immune‐mediated inflammatory diseases. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 8, 2017 Category: Rheumatology Authors: Roy M. Fleischmann, Frank Wagner, Alan J. Kivitz, Heikki T. Mansikka, Nasser Khan, Ahmed A. Othman, Amit Khatri, Feng Hong, Ping Jiang, Melanie Ruzek, Robert J. Padley Tags: Original Article Source Type: research
Arthritis in Melorheostosis. An uncommon feature in a rare disease
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 6, 2017 Category: Rheumatology Authors: Enrico Selvi, Marco Bardelli, Giacomo Maria Guidelli Tags: Clinical Image Source Type: research
