Genetic variants in ERAP1 and ERAP2 associated with immune ‐mediated diseases influence protein expression and isoform profile
ConclusionsIn accordance with studies demonstrating that polymorphisms that increase aminopeptidase activity predispose to immune disease, the elevated risk also attributed to increased expression of ERAP1 and ERAP2 supports the therapeutic notion of aminopeptidase inhibition to treat AS and other ERAP associated conditions.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 6, 2017 Category: Rheumatology Authors: Aimee L. Hanson, Thomas Cuddihy, Katelin Haynes, Dorothy Loo, Craig J. Morton, Udo Oppermann, Paul Leo, Gethin P. Thomas, Kim ‐Anh Lê Cao, Tony J. Kenna, Matthew A. Brown Tags: Full Length Source Type: research
Reply
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 2, 2017 Category: Rheumatology Authors: James M. Gwinnutt, Deborah P. M. Symmons, Mark Lunt, Suzanne M. M. Verstappen Tags: Letters Source Type: research
Could autophagy induced by misfolded mutant α1‐antitrypsin Z in synovitis explain the association of α1‐antitrypsin Z with increased anti–citrullinated protein antibody production in rheumatoid arthritis? Comment on the article by McCarthy et al
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 2, 2017 Category: Rheumatology Authors: David Hutchinson, Paul Eggleton Tags: Letters Source Type: research
Updated estimates suggest a much higher prevalence of arthritis in US adults than previous ones
ConclusionArthritis prevalence in the US population has been substantially underestimated, especially among adults <65 years.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 1, 2017 Category: Rheumatology Authors: S.Reza Jafarzadeh, David T. Felson Tags: Full Length Source Type: research
A thrombin receptor ‐ derived imaging agent detects subclinical arthritis in mice
ConclusionRACPPNleTPRSFL activation detects established experimental arthritis and the detection of inflammation by RACPPNleTPRSFL on Day 1 of STIA correlates with disease progression.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 1, 2017 Category: Rheumatology Authors: Beth Friedman, Michael A. Whitney, Elamprakash N. Savariar, Christa Caneda, Paul Steinbach, Qing Xiong, Dina V. Hingorani, Jessica Crisp, Stephen R. Adams, Michael Kenner, Csilla N. Lippert, Quyen T. Nguyen, Monica Guma, Roger Y. Tsien, Maripat Corr Tags: Full Length Source Type: research
Validation of a definition for flare in patients with established gout
ConclusionsThe definition requiring the presence of ≥ 3 out of 4 patient‐reported criteria is now validated to be sensitive, specific, and accurate for gout flares (attacks) using an independent, large international sample. The availability of a validated gout flare definition will improve the ascertainment of an important clinical outcome in studies of gout.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 1, 2017 Category: Rheumatology Authors: Angelo L. Gaffo, Nicola Dalbeth, Kenneth G. Saag, Jasvinder A. Singh, Elizabeth J. Rahn, Amy S. Mudano, Yi ‐Hsing Chen, Ching‐Tsai Lin, Sandra Bourke, Worawit Louthrenoo, Janitzia Vazquez‐Mellado, Hansel Hernández‐Llinas, Tuhina Neogi, Ana Beatri Tags: Brief Report Source Type: research
Positron Emission Tomography as an Imaging Biomarker in a Prospective, Longitudinal Cohort of Patients with Large Vessel Vasculitis
ConclusionsFDG‐PET provides information about vascular inflammation that is complimentary to, and unique from, clinical assessment in LVV. FDG‐PET scan activity during clinical remission was associated with future clinical relapse.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 1, 2017 Category: Rheumatology Authors: Peter C. Grayson, Sara Alehashemi, Armin A. Bagheri, Ali Cahid Civelek, Thomas R. Cupps, Mariana J. Kaplan, Ashkan A. Malayeri, Peter A. Merkel, Elaine Novakovich, David A. Bluemke, Mark A. Ahlman Tags: Full Length Source Type: research
Dermatological Addendum to the 2012 International Chapel Hill Consensus Conference Nomenclature of Vasculitides
ConclusionsStandardized names and definitions are a prerequisite for developing validated classification and diagnostic criteria for cutaneous vasculitis. Accurate identification of specifically defined variants of systemic and skin‐limited vasculitides requires knowledgeable integration of clinical, laboratory and pathology data. The proposed nomenclature for vasculitides affecting the skin provides a standard framework for both clinicians and investigators.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 1, 2017 Category: Rheumatology Authors: Cord H. Sunderk ötter, Bernhard Zelger, Ko‐Ron Chen, Luis Requena, Warren Piette, J. Andrew Carlson, Jan Dutz, Peter Lamprecht, Alfred Mahr, Elisabeth Aberer, Victoria P. Werth, David A. Wetter, Seiji Kawana, Raashid Luqmani, Camille Frances, Joseph Tags: Full Length Source Type: research
The innate and adaptive immune response are both involved in drug ‐induced autoimmunity
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 1, 2017 Category: Rheumatology Authors: Amr H Sawalha Tags: Editorial Source Type: research
Reply to Bigler et al. (ar‐17‐1461)
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 1, 2017 Category: Rheumatology Authors: Bryant R. England, Ted R. Mikuls, Jeffrey R. Curtis Tags: Reply to Letter to the Editor Source Type: research
TNF ‐α inhibitors are associated with reduced indices of subclinical atherosclerosis in patients with psoriatic disease
ConclusionTNFi treatment was associated with reduced progression of carotid plaques in men and improvement in vascular inflammation in psoriatic patients.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 1, 2017 Category: Rheumatology Authors: Lihi Eder, Aditya A. Joshi, Amit K. Dey, Richard Cook, Evan L. Siegel, Dafna D Gladman, Nehal N. Mehta Tags: Full Length Source Type: research
Disease Damage and Acute Phase Reactants in IgG4 ‐Related Disease
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 31, 2017 Category: Rheumatology Authors: Cory A Perugino, John H Stone Tags: Reply to Letter to the Editor Source Type: research
Emerging Treatment Models in Rheumatology: IgG4 ‐Related Disease: Insights Into Human Immunology and Targeted Therapies. Comments on the article by Perugino et al
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 31, 2017 Category: Rheumatology Authors: A. Faiz Karim, Laura. E.M. Eurelings, P. Martin van Hagen, Jan. A.M van Laar Tags: Letter to the Editor Source Type: research
Varicella Zoster Virus specific T cell responses in untreated Giant Cell Arteritis
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 31, 2017 Category: Rheumatology Authors: Marc B. Bigler, Julia R. Hirsiger, Mike Recher, Matthias Mehling, Thomas Daikeler, Christoph T. Berger Tags: Letter to the Editor Source Type: research
Phase 2b trial of a novel extended ‐release microsphere formulation of triamcinolone acetonide for intra‐articular injection in knee osteoarthritis
ConclusionAlthough the primary endpoint was not met, FX006 demonstrated a prolonged reduction in symptoms with an evident dose response and a safety profile similar to that of saline‐placebo.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 31, 2017 Category: Rheumatology Authors: Philip G Conaghan, Stanley B Cohen, Francis Berenbaum, Joelle Lufkin, James R Johnson, Neil Bodick Tags: Brief Report Source Type: research
