Lupus regulator peptide P140 represses B ‐cell differentiation by reducing HLA class II molecule overexpression
ConclusionsOur findings show that P140 down‐regulates HLA class II overexpression in human lupus B cells and that likely via a resulting lack of T cell signaling and activation, it hampers B cells differentiation into autoantibody‐secreting plasma cells. This mechanism likely switches off the downstream events leading to pathogenic autoantibodies secretion, thus explaining the highly promising results obtained in P140/Lupuzor™ ‐based clinical trials.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 1, 2018 Category: Rheumatology Authors: Maud Wilhelm, Fengjuan Wang, Nicolas Schall, Jean ‐François Kleinmann, Michael Faludi, Emil Pablo Nashi, Jean Sibilia, Thierry Martin, Evelyne Schaeffer, Sylviane Muller Tags: Full Length Source Type: research
Inflammation Intensity ‐dependent Expression of Osteoinductive Wnt Proteins is Critical for Ectopic New Bone Formation in Ankylosing Spondylitis
ConclusionsInflammation intensity‐dependent expression of osteoinductive Wnt proteins is a key link between inflammation and ectopic new bone formation in AS. Activation of both canonical Wnt/β‐catenin and noncanonical Wnt/PKCδ pathways is required for inflammation‐induced new bone formation.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 27, 2018 Category: Rheumatology Authors: Xiang Li, Jianru Wang, Zhongping Zhan, Sibei Li, Zhaomin Zheng, Taiping Wang, Kuibo Zhang, Hehai Pan, Zemin Li, Nu Zhang, Hui Liu Tags: Full Length Source Type: research
Utilization and Short ‐Term Outcomes of Primary Total Hip and Knee Arthroplasty in the United States and Canada
ConclusionOntario has higher utilization of total joint arthroplasty than New York but has a smaller percentage of hospitals performing these procedures. Patients are more likely to be discharged home and less likely to be readmitted in Ontario. Our results suggest areas where each jurisdiction could improve. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Authors: Peter Cram, Bruce E. Landon, John Matelski, Vicki Ling, Therese A. Stukel, J. Michael Paterson, Rajiv Gandhi, Gillian A. Hawker, Bheeshma Ravi Tags: Original Article Source Type: research
Diffuse idiopathic skeletal hyperostosis; on the wrong side?
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Authors: Henk A. Martens, Simone S. Boks Tags: Clinical Image Source Type: research
Subcutaneous Abatacept in Patients With Polyarticular ‐Course Juvenile Idiopathic Arthritis: Results From a Phase III Open‐Label Study
ConclusionWeight‐stratified SC abatacept yielded target therapeutic exposures across age and weight groups, was well tolerated, and improved pJIA symptoms over 24 months.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Authors: Hermine I Brunner, Nikolay Tzaribachev, Gabriel Vega ‐Cornejo, Ingrid Louw, Alberto Berman, Inmaculada Calvo Penadés, Jordi Antón, Francisco Ávila‐Zapata, Rubén Cuttica, Gerd Horneff, Ivan Foeldvari, Vladimir Keltsev, Daniel J Kingsbury, Diego Osc Tags: Full Length Source Type: research
Lgals9 deficiency attenuates nephritis and arthritis in pristane ‐induced lupus model of BALB/c mice
ConclusionGalectin‐9 is required for the induction and development of lupus nephritis and arthritis in pristane‐induced mice model of SLE. The current investigation provided a new strategy, in which the antagonism of Galectin‐9 is beneficial for the treatment of nephritis and arthritis in SLE by targeting activated macrophages.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Authors: Sonia Zeggar, Katsue S. Watanabe, Sanae Teshigawara, Sumie Hiramatsu, Takayuki Katsuyama, Eri Katsuyama, Haruki Watanabe, Yoshinori Matsumoto, Tomoko Kawabata, Ken ‐ei Sada, Toshiro Niki, Mitsuomi Hirashima, Jun Wada Tags: Full Length Source Type: research
ACR Announcements
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Tags: ACR Announcements Source Type: research
Error in Percent Increased SRI ‐6 Response Rate in Subgroup of Atacicept‐Treated Patients Versus Placebo in the Article by Merrill et al (Arthritis Rheumatol, February 2018)
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Tags: Errata Source Type: research
Error in Description of Enzyme Range Calculations in Footnote of Table 3 in the Article by Rider et al (Arthritis Rheumatol, May 2017)
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Tags: Errata Source Type: research
Clinical Connections
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Tags: Clinical Connections Source Type: research
In This Issue
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Tags: In This Issue Source Type: research
Issue Information
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Tags: Issue Information Source Type: research
Abnormal B Cell Development in Systemic Lupus Erythematosus
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 22, 2018 Category: Rheumatology Authors: Sarah Karrar, Deborah S. Cunninghame Graham Tags: Review Source Type: research
Reply
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 22, 2018 Category: Rheumatology Authors: R. Hal Scofield, Rohan Sharma, Valerie M. Harris Tags: Letters Source Type: research
High Levels of DEK Autoantibodies in Sera of Patients With Polyarticular Juvenile Idiopathic Arthritis and With Early Disease Flares Following Cessation of Anti –Tumor Necrosis Factor Therapy
ConclusionDEK autoantibody levels are higher in patients with polyarticular JIA than in those with oligoarticular JIA, and higher in patients who have disease flares after cessation of anti‐TNF therapy. The C‐terminal 25‐aa fragment is the most immunogenic portion of DEK. These findings are significant with respect to the nature of DEK autoantibodies, their contribution to JIA pathogenesis, and their implications for JIA management. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 22, 2018 Category: Rheumatology Authors: Nirit Mor ‐Vaknin, Miguel Rivas, Maureen Legendre, Smriti Mohan, Ye Yuanfan, Theresa Mau, Anne Johnson, Bin Huang, Lili Zhao, Yukiko Kimura, Steven J. Spalding, Paula W. Morris, Beth S. Gottlieb, Karen Onel, Judyann C. Olson, Barbara S. Edelheit, Michae Tags: Original Article Source Type: research
