Lupus regulator peptide P140 represses B ‐cell differentiation by reducing HLA class II molecule overexpression

ConclusionsOur findings show that P140 down‐regulates HLA class II overexpression in human lupus B cells and that likely via a resulting lack of T cell signaling and activation, it hampers B cells differentiation into autoantibody‐secreting plasma cells. This mechanism likely switches off the downstream events leading to pathogenic autoantibodies secretion, thus explaining the highly promising results obtained in P140/Lupuzor™ ‐based clinical trials.This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatism - March 1, 2018 Category: Rheumatology Authors: Maud Wilhelm, Fengjuan Wang, Nicolas Schall, Jean ‐François Kleinmann, Michael Faludi, Emil Pablo Nashi, Jean Sibilia, Thierry Martin, Evelyne Schaeffer, Sylviane Muller Tags: Full Length Source Type: research