Single ‐strain versus multistrain probiotic supplementation treatment strategy for rheumatoid arthritis: comment on the article by Marietta et al
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 15, 2017 Category: Rheumatology Authors: Giancarlo Ceccarelli, Vincenzo Vullo, Gabriella d'Ettorre Tags: Letters Source Type: research
Predictive Validity of Radiographic Trabecular Bone Texture in Knee Osteoarthritis
ConclusionAlthough associations are modest, TBT could be an attractive means of enriching OA trials for progressors since it can be generated from screening knee radiographs already standard in knee OA clinical trials. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 15, 2017 Category: Rheumatology Authors: Virginia Byers Kraus, Jamie E. Collins, H. Cecil Charles, Carl F. Pieper, Lawrence Whitley, Elena Losina, Michael Nevitt, Steve Hoffmann, Frank Roemer, Ali Guermazi, David J. Hunter, Tags: Original Article Source Type: research
Transcriptional regulation of CD4+ T cell differentiation in experimentally ‐induced arthritis and rheumatoid arthritis
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 15, 2017 Category: Rheumatology Authors: Yuya Kondo, Masahiro Yokosawa, Shunta Kaneko, Kotona Furuyama, Seiji Segawa, Hiroto Tsuboi, Isao Matsumoto, Takayuki Sumida Tags: Review Article Source Type: research
Editorial: Bone Reading to Predict the Future
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 8, 2017 Category: Rheumatology Authors: Martin Englund, Aleksandra Turkiewicz, Pawel Podsiadlo Tags: Editorial Source Type: research
The Antiretroviral Agent Nelfinavir Mesylate
ConclusionNFV abrogates TGFβ1‐mediated fibroblast‐to‐myofibroblast differentiation and pulmonary fibrosis through off‐target protein binding, a finding that supports consideration of this FDA‐approved medication as an antifibrotic agent. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 8, 2017 Category: Rheumatology Authors: Cecilia G. Sanchez, Steven V. Molinski, Rafael Gongora, Meredith Sosulski, Taylor Fuselier, Stephen S. MacKinnon, Debasis Mondal, Joseph A. Lasky Tags: Original Article Source Type: research
Subjective Complaints as the Main Reason for Biosimilar Discontinuation After Open ‐Label Transition From Reference Infliximab to Biosimilar Infliximab
ConclusionIn our cohort, one‐fourth of patients discontinued CT‐P13 during 6 months of follow‐up, mainly due to an increase in the subjective features of the tender joint count and the patient's global assessment of disease activity and/or subjective AEs, possibly explained by nocebo effects and/or incorrect causal attribution effects. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 7, 2017 Category: Rheumatology Authors: Lieke Tweehuysen, Bart J. F. Bemt, Iris L. Ingen, Alphons J. L. Jong, Willemijn H. Laan, Frank H. J. Hoogen, Alfons A. Broeder Tags: Original Article Source Type: research
Familial Mediterranean Fever and Incidence of Cancer
ConclusionFMF patients have a significantly lower incidence of cancer than the general population of Israel. This pattern was demonstrated in 2 ethnic populations: Jewish and Arab. We speculate that the lower cancer incidence could be attributed to a direct physiologic effect of FMF or to its treatment. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 7, 2017 Category: Rheumatology Authors: Ronen Brenner, Ilan Ben ‐Zvi, Yael Shinar, Irena Liphshitz, Barbara Silverman, Nir Peled, Carmit Levy, Eldad Ben‐Chetrit, Avi Livneh, Shaye Kivity Tags: Original Article Source Type: research
Weight Change During the Early Rheumatoid Arthritis Period and Risk of Subsequent Mortality in Women With Rheumatoid Arthritis and Matched Comparators
ConclusionSevere weight loss during the early RA period was associated with an increased subsequent mortality risk for women with and those without RA. These results extend prior observations by including non‐RA comparators and finding no protective association between weight gain and mortality, providing evidence against an RA‐specific obesity paradox for mortality. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 7, 2017 Category: Rheumatology Authors: Jeffrey A. Sparks, Shun ‐Chiao Chang, Uyen‐Sa Nguyen, Medha Barbhaiya, Sara K. Tedeschi, Bing Lu, David J. Kreps, Karen H. Costenbader, Yuqing Zhang, Hyon K. Choi, Elizabeth W. Karlson Tags: Original Article Source Type: research
Brief Report: Rituximab for the Treatment of Adult ‐Onset IgA Vasculitis (Henoch‐Schönlein)
ConclusionOur data suggest that RTX is an effective and safe therapeutic option for adult‐onset IgAV. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 1, 2017 Category: Rheumatology Authors: Federica Maritati, Roberta Fenoglio, Evangeline Pillebout, Giacomo Emmi, Maria L. Urban, Rossana Rocco, Maria Nicastro, Monia Incerti, Matteo Goldoni, Giorgio Trivioli, Elena Silvestri, Aladdin J. Mohammad, David Jayne, Per Eriksson, M årten Segelmark, P Tags: Brief Report Source Type: research
Review: Genetics and the Classification of Arthritis in Adults and Children
Current classification of primary inflammatory arthritis begins from the assumption that adults and children are different. No form of juvenile idiopathic arthritis bears the same name as an adult arthritis, a nomenclature gap with implications for both clinical care and research. Recent genetic data have raised questions regarding this adult/pediatric divide, revealing instead broad patterns that span the age spectrum. Combining these genetic patterns with demographic and clinical data, we propose that inflammatory arthritis can be segregated into 4 main clusters, largely irrespective of pediatric or adult onset: seroposi...
Source: Arthritis and Rheumatism - December 1, 2017 Category: Rheumatology Authors: Peter A. Nigrovic, Soumya Raychaudhuri, Susan D. Thompson Tags: Review Source Type: research
Antibody Responses to Citrullinated and Non ‐Citrullinated Antigens in the Sputum of Subjects with and At‐Risk for Rheumatoid Arthritis
ConclusionsThese findings suggest that sputum antibody reactivity to particular cit and non‐cit proteins/peptides is specific for At‐Risk and RA subjects, and their association with NETs may be a key feature of early RA‐related autoimmunity in the lung. These findings further support the hypothesis that the lung plays a role in early RA‐related autoimmunity.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 1, 2017 Category: Rheumatology Authors: M. Kristen Demoruelle, Emily Bowers, Lauren J. Lahey, Jeremy Sokolove, Monica Purmalek, Nickie L. Seto, Michael H. Weisman, Jill M. Norris, Mariana J. Kaplan, V. Michael Holers, Robinson H. William, Kevin D. Deane Tags: Full Length Source Type: research
Frequency of Chronic Joint Pain following Chikungunya Infection: A Colombian Cohort Study
ConclusionsThis is the first report to describe the frequency of chikungunya‐related arthritis in the Americas after a 20‐month follow‐up. The high frequency of chronic disease highlights the importance of development of prevention and treatment interventions.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 1, 2017 Category: Rheumatology Authors: Aileen Y. Chang, Liliana Encinales, Alexandra Porras, Nelly Pachecho, St. Patrick Reid, Karen A.O. Martins, Shamila Pacheco, Eyda Bravo, Marianda Navarno, Alejandro Rico, Richard Amdur, Priyanka Kamalopathy, Gary S. Firestein, Jeffrey M. Bethony, Gary L. Tags: Full Length Source Type: research
Increased expression and modulated regulatory activity of co ‐inhibitory receptors PD‐1, TIGIT and TIM‐3 in lymphocytes of systemic sclerosis patients
ConclusionsAltered expression and regulatory capacity of co‐IRs in SSc lymphocytes may contribute to disease pathophysiology by modulating the cytokine‐mediated crosstalk of immune cells and fibroblasts at inflammatory and/or fibrotic sites.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 1, 2017 Category: Rheumatology Authors: Michelle Fleury, Anna C. Belkina, Elizabeth A. Proctor, Christopher Zammitti, Robert W. Simms, Douglas A. Lauffenburger, Jennifer E. Snyder ‐Cappione, Robert Lafyatis, Hans Dooms Tags: Full Length Source Type: research
Abnormal B ‐cell development in Systemic Lupus Erythematosus: what the genetics tell us
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 1, 2017 Category: Rheumatology Authors: Sarah Karrar, Deborah S Cunninghame Graham Tags: Review Article Source Type: research
Rituximab for the Treatment of Adult ‐Onset IgA Vasculitis (Henoch‐Schönlein)
ConclusionOur data suggest that RTX is an effective and safe therapeutic option for adult‐onset IgAV. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 1, 2017 Category: Rheumatology Authors: Federica Maritati, Roberta Fenoglio, Evangeline Pillebout, Giacomo Emmi, Maria L. Urban, Rossana Rocco, Maria Nicastro, Monia Incerti, Matteo Goldoni, Giorgio Trivioli, Elena Silvestri, Aladdin J. Mohammad, David Jayne, Per Eriksson, M årten Segelmark, P Tags: Brief Report Source Type: research
