Antibody Responses to Citrullinated and Non ‐Citrullinated Antigens in the Sputum of Subjects with and At‐Risk for Rheumatoid Arthritis

ConclusionsThese findings suggest that sputum antibody reactivity to particular cit and non‐cit proteins/peptides is specific for At‐Risk and RA subjects, and their association with NETs may be a key feature of early RA‐related autoimmunity in the lung. These findings further support the hypothesis that the lung plays a role in early RA‐related autoimmunity.This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatism - December 1, 2017 Category: Rheumatology Authors: M. Kristen Demoruelle, Emily Bowers, Lauren J. Lahey, Jeremy Sokolove, Monica Purmalek, Nickie L. Seto, Michael H. Weisman, Jill M. Norris, Mariana J. Kaplan, V. Michael Holers, Robinson H. William, Kevin D. Deane Tags: Full Length Source Type: research