Increased expression and modulated regulatory activity of co ‐inhibitory receptors PD‐1, TIGIT and TIM‐3 in lymphocytes of systemic sclerosis patients

ConclusionsAltered expression and regulatory capacity of co‐IRs in SSc lymphocytes may contribute to disease pathophysiology by modulating the cytokine‐mediated crosstalk of immune cells and fibroblasts at inflammatory and/or fibrotic sites.This article is protected by copyright. All rights reserved.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fart.40399

Source: Arthritis and Rheumatism - December 1, 2017 Category: Rheumatology Authors: Michelle Fleury, Anna C. Belkina, Elizabeth A. Proctor, Christopher Zammitti, Robert W. Simms, Douglas A. Lauffenburger, Jennifer E. Snyder ‐Cappione, Robert Lafyatis, Hans Dooms Tags: Full Length Source Type: research

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