The Antiretroviral Agent Nelfinavir Mesylate

ConclusionNFV abrogates TGFβ1‐mediated fibroblast‐to‐myofibroblast differentiation and pulmonary fibrosis through off‐target protein binding, a finding that supports consideration of this FDA‐approved medication as an antifibrotic agent.

Source: Arthritis and Rheumatism - December 8, 2017 Category: Rheumatology Authors: Cecilia G. Sanchez, Steven V. Molinski, Rafael Gongora, Meredith Sosulski, Taylor Fuselier, Stephen S. MacKinnon, Debasis Mondal, Joseph A. Lasky Tags: Original Article Source Type: research