Association of Natural Killer Cell Ligand Polymorphism HLA –C Asn80Lys With the Development of Anti‐SSA/Ro–Associated Congenital Heart Block
ConclusionThese data establish C2 as a novel genetic risk factor associated with CHB. This observation supports a model in which fetuses with C2 ligand expression and maternal anti‐SSA/Ro positivity may have impaired NK cell surveillance, resulting in unchecked cardiac inflammation and scarring.
Source: Arthritis and Rheumatism - Category: Rheumatology Authors: Hannah C. Ainsworth, Miranda C. Marion, Tiziana Bertero, Antonio Brucato, Rolando Cimaz, Nathalie Costedoat ‐Chalumeau, Micaela Fredi, Patrick Gaffney, Jennifer Kelly, Kateri Levesque, Alice Maltret, Nathalie Morel, Veronique Ramoni, Amelia Ruffatti, Ca Tags: Brief Report Source Type: research
More News: Arthritis | Cardiology | Child Development | Children | Genetics | Heart | Rheumatology | Study