Advances in Protein Chemistry and Structural Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Elucidating the Mutational Landscape in Hepatocyte Nuclear Factor 1 β (HNF1B) by Computational Approach
Publication date: Available online 3 January 2017 Source:Advances in Protein Chemistry and Structural Biology Author(s): P. Sneha, C.G.P. Doss Transcription factors are the major gene-regulatory proteins that recognize specific nucleotide sequences and bind to them. Missense mutations in transcription factors play a significant role in misregulation of gene expression contributing to various diseases and disorders. Understanding their structural and functional impact of the disease-causing mutations becomes prime importance in treating a disease. Commonly associated defect with the mutations of hepatocyte nuclear f...
Source: Advances in Protein Chemistry and Structural Biology - January 3, 2017 Category: Biochemistry Source Type: research
Chapter Nine Chromatin Remodeling and Plant Immunity
Publication date: 2017 Source:Advances in Protein Chemistry and Structural Biology, Volume 106 Author(s): W. Chen, Q. Zhu, Y. Liu, Q. Zhang Chromatin remodeling, an important facet of the regulation of gene expression in eukaryotes, is performed by two major types of multisubunit complexes, covalent histone- or DNA-modifying complexes, and ATP-dependent chromosome remodeling complexes. Snf2 family DNA-dependent ATPases constitute the catalytic subunits of ATP-dependent chromosome remodeling complexes, which accounts for energy supply during chromatin remodeling. Increasing evidence indicates a critical role of ...
Source: Advances in Protein Chemistry and Structural Biology - January 1, 2017 Category: Biochemistry Source Type: research
Chapter Eight A New Molecular Mechanism Underlying the Antitumor Effect of DNA Methylation Inhibitors via an Antiviral Immune Response
Publication date: 2017 Source:Advances in Protein Chemistry and Structural Biology, Volume 106 Author(s): Y. Saito, T. Nakaoka, H. Saito Chromatin remodeling mediated by DNA methylation and histone modifications play critical roles in the transcriptional regulation of protein-coding genes, noncoding RNAs such as microRNAs, and endogenous retroviruses (ERVs). Many studies have shown that aberrant DNA methylation and histone modifications are associated with the initiation and progression of various malignancies. Epigenetic silencing of tumor suppressor genes in cancer is generally mediated by DNA hypermethylation ...
Source: Advances in Protein Chemistry and Structural Biology - January 1, 2017 Category: Biochemistry Source Type: research
Chapter Seven Regulation of Cellular Immune Responses in Sepsis by Histone Modifications
Publication date: 2017 Source:Advances in Protein Chemistry and Structural Biology, Volume 106 Author(s): W.F. Carson, S.L. Kunkel Severe sepsis, septic shock, and related inflammatory syndromes are driven by the aberrant expression of proinflammatory mediators by immune cells. During the acute phase of sepsis, overexpression of chemokines and cytokines drives physiological stress leading to organ failure and mortality. Following recovery from sepsis, the immune system exhibits profound immunosuppression, evidenced by an inability to produce the same proinflammatory mediators that are required for normal responses ...
Source: Advances in Protein Chemistry and Structural Biology - January 1, 2017 Category: Biochemistry Source Type: research
Chapter Six Epigenetic Changes in Chronic Inflammatory Diseases
Publication date: 2017 Source:Advances in Protein Chemistry and Structural Biology, Volume 106 Author(s): O. Fogel, C. Richard-Miceli, J. Tost The number of people diagnosed with chronic inflammatory diseases has increased noteworthy in the last 40 years. Spondyloarthritis (SpA), inflammatory bowel diseases (IBD), and psoriasis are the most frequent chronic inflammatory diseases, resulting from a combination of genetic predisposition and environmental factors. Epigenetic modifications include DNA methylation, histone modifications, and small and long noncoding RNAs. They are influenced by environmental exposure, ...
Source: Advances in Protein Chemistry and Structural Biology - January 1, 2017 Category: Biochemistry Source Type: research
Chapter Five Mechanisms of Chromatin Remodeling and Repurposing During Extracellular Translocation
Publication date: 2017 Source:Advances in Protein Chemistry and Structural Biology, Volume 106 Author(s): D.S. Pisetsky Chromatin is a highly conserved molecular structure that provides genetic information to regulate cell function. Comprised of DNA, histones and interacting proteins, chromatin is inherently dynamic and subject to remodeling. While usually conceptualized as an intranuclear event, remodeling can also involve extracellular movement. Indeed, chromatin can translocate entirely from the inside to the outside of the cell during cell death processes that include apoptosis, necrosis, and NETosis. During thes...
Source: Advances in Protein Chemistry and Structural Biology - January 1, 2017 Category: Biochemistry Source Type: research
Chapter Four Histone Acetylation and the Regulation of Major Histocompatibility Class II Gene Expression
Publication date: 2017 Source:Advances in Protein Chemistry and Structural Biology, Volume 106 Author(s): K. Suzuki, Y. Luo Major histocompatibility complex (MHC) class II molecules are essential for processing and presenting exogenous pathogen antigens to activate CD4+ T cells. Given their central role in adaptive immune responses, MHC class II genes are tightly regulated in a tissue- and activation-specific manner. The regulation of MHC class II gene expression involves various transcription factors that interact with conserved proximal cis-acting regulatory promoter elements, as well as MHC class II transactivat...
Source: Advances in Protein Chemistry and Structural Biology - January 1, 2017 Category: Biochemistry Source Type: research
Chapter Three The Role of Epigenetic Regulation in Transcriptional Memory in the Immune System
Publication date: 2017 Source:Advances in Protein Chemistry and Structural Biology, Volume 106 Author(s): A.M. Woodworth, A.F. Holloway The immune system is exquisitely poised to identify, respond to, and eradicate pathogens from the body, as well as to produce a more rapid and augmented response to a subsequent encounter with the pathogen. These cellular responses rely on the highly coordinated and rapid activation of gene expression programs as well as the ability of the cell to retain a memory of the initial gene response. It is clear that chromatin structure and epigenetic mechanisms play a crucial role in dete...
Source: Advances in Protein Chemistry and Structural Biology - January 1, 2017 Category: Biochemistry Source Type: research
Chapter Two Roles of SMC Complexes During T Lymphocyte Development and Function
Publication date: 2017 Source:Advances in Protein Chemistry and Structural Biology, Volume 106 Author(s): J.S. Rawlings T lymphocytes (T cells) comprise a critical component of the immune system charged with diverse functions during an immune response. As a function of maturation in the thymus, T cells become quiescent and remain so until they participate in an immune response in the periphery. Recent work indicates that the control of T cell proliferation is mediated, at least in part, by chromatin architecture. Quiescent T cells possess a condensed chromatin, whereas proliferating T cells have a more open chromatin...
Source: Advances in Protein Chemistry and Structural Biology - January 1, 2017 Category: Biochemistry Source Type: research
Chapter One Chromatin Remodeling in Monocyte and Macrophage Activation
Publication date: 2017 Source:Advances in Protein Chemistry and Structural Biology, Volume 106 Author(s): J.L. Schultze Increasing evidence collected during the last years supports the idea that monocyte and macrophage activation is not only associated with transcriptional changes but also changes in the chromatin landscape. Moreover, the introduction of a multidimensional model of macrophage activation allows a more precise description of monocytes and macrophages under homeostatic and pathophysiological conditions. Monocytes and macrophages are masters of integrating microenvironmental signals, thereby reshaping th...
Source: Advances in Protein Chemistry and Structural Biology - January 1, 2017 Category: Biochemistry Source Type: research
The Functional Stability of FOXP3 and ROR γt in Treg and Th17 and Their Therapeutic Applications
Publication date: Available online 15 December 2016 Source:Advances in Protein Chemistry and Structural Biology Author(s): J. Ren, B. Li The balance of CD4+CD25+FOXP3+ regulatory T cells (Tregs) and effector T cells plays a key role in maintaining immune homeostasis, while the imbalance of them is related to many inflammatory diseases in both human and mice. Here we discuss about the plasticity of Tregs and Th17 cells, and the related human diseases resulted from the imbalance of them. Further, we will focus on the mechanisms regulating the plasticity between Tregs and Th17 cells and the potential therapeutic strat...
Source: Advances in Protein Chemistry and Structural Biology - December 14, 2016 Category: Biochemistry Source Type: research
Transcription Factors in Breast Cancer —Lessons From Recent Genomic Analyses and Therapeutic Implications
Publication date: Available online 12 December 2016 Source:Advances in Protein Chemistry and Structural Biology Author(s): E. Zacksenhaus, J.C. Liu, Z. Jiang, Y. Yao, L. Xia, M. Shrestha, Y. Ben-David Multiplatform genomic analyses have identified 93 frequently altered genes in breast cancer. Of these, as many as 49 genes are directly or indirectly involved in transcription. These include constitutive and inducible DNA-binding transcription factors (DB-TFs, 13 genes), corepressors/coactivators (14 genes), epigenetic (10), and mediator/splicing/rRNA (3) factors. At least nine additional genes are immediate...
Source: Advances in Protein Chemistry and Structural Biology - December 12, 2016 Category: Biochemistry Source Type: research
NF- κB as a Therapeutic Target in Inflammatory-Associated Bone Diseases
Publication date: Available online 9 December 2016 Source:Advances in Protein Chemistry and Structural Biology Author(s): T.-h. Lin, J. Pajarinen, L. Lu, A. Nabeshima, L.A. Cordova, Z. Yao, S.B. Goodman Inflammation is a defensive mechanism for pathogen clearance and maintaining tissue homeostasis. In the skeletal system, inflammation is closely associated with many bone disorders including fractures, nonunions, periprosthetic osteolysis (bone loss around orthopedic implants), and osteoporosis. Acute inflammation is a critical step for proper bone-healing and bone-remodeling processes. On the other hand, ...
Source: Advances in Protein Chemistry and Structural Biology - December 10, 2016 Category: Biochemistry Source Type: research
The Complex Role of the ZNF224 Transcription Factor in Cancer
Publication date: Available online 5 December 2016 Source:Advances in Protein Chemistry and Structural Biology Author(s): E. Cesaro, G. Sodaro, G. Montano, M. Grosso, A. Lupo, P. Costanzo ZNF224 is a member of the Kruppel-associated box zinc finger proteins (KRAB-ZFPs) family. It was originally identified as a transcriptional repressor involved in gene-specific silencing through the recruitment of the corepressor KAP1, chromatin-modifying activities, and the arginine methyltransferase PRMT5 on the promoter of its target genes. Recent findings indicate that ZNF224 can behave both as a tumor suppressor or an ...
Source: Advances in Protein Chemistry and Structural Biology - December 5, 2016 Category: Biochemistry Source Type: research
Transcription Factors as a Target for Vaccination Against Ticks and Mites
Publication date: Available online 5 December 2016 Source:Advances in Protein Chemistry and Structural Biology Author(s): O.A.E. Sparagano Ticks and mites are well-known ectoparasites as potential vectors for numerous bacteria, viruses, and parasites. Many being blood feeders add to physiological deterioration, morbidity, and mortality of their vertebrate hosts. To control them, transcription factors have been identified and studied in their role to sustain such arthropod pests. This paper summarizes some of the work done on those factors involved during blood feeding, reproduction, or when interacting with their pat...
Source: Advances in Protein Chemistry and Structural Biology - December 5, 2016 Category: Biochemistry Source Type: research
