Advances in Protein Chemistry and Structural Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Chapter Eight Personalized Pharmacoperones for Lysosomal Storage Disorder
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 102 Author(s): S.A. Syed Haneef, C. George Priya Doss Lysosomal storage disorders (LSDs) are a collection of inborn errors of metabolic disorders affected by mutations in lysosome functional genes, commonly acid hydrolases. From the past decades, many approaches like enzyme replacement therapy, substrate reduction therapy are followed to treat these conditions. However, all these approaches have their own limitations. Proof-of-concept studies on pharmacological chaperone therapy (PCT) is now transformed into clinical practice...
Source: Advances in Protein Chemistry and Structural Biology - January 29, 2016 Category: Biochemistry Source Type: research

Chapter Seven Molecular Dynamics
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 102 Author(s): P. Sneha, C. George Priya Doss The field of drug discovery has witnessed infinite development over the last decade with the demand for discovery of novel efficient lead compounds. Although the development of novel compounds in this field has seen large failure, a breakthrough in this area might be the establishment of personalized medicine. The trend of personalized medicine has shown stupendous growth being a hot topic after the successful completion of Human Genome Project and 1000 genomes pilot project. Geno...
Source: Advances in Protein Chemistry and Structural Biology - January 29, 2016 Category: Biochemistry Source Type: research

Chapter Six Computational Approaches to Accelerating Novel Medicine and Better Patient Care from Bedside to Benchtop
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 102 Author(s): Theodore Sakellaropoulos, Junguk Hur, Ioannis N. Melas, Ellen Y. Guo, Leonidas Alexopoulos, Mohammad Bohlooly, Jane P.F. Bai Some successes have been achieved in the war on cancer over the past 30 years with recent efforts on protein kinase inhibitors. Nonetheless, we are still facing challenges due to cancer evolution. Cancers are complex and heterogeneous due to primary and secondary mutations, with phenotypic and molecular heterogeneity manifested among patients of a cancer, and within an individua...
Source: Advances in Protein Chemistry and Structural Biology - January 29, 2016 Category: Biochemistry Source Type: research

Chapter Five Personalized Medicine in Respiratory Disease
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 102 Author(s): V.S. Priyadharshini, Luis M. Teran Respiratory diseases affect humanity globally, with chronic lung diseases (e.g., asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, among others) and lung cancer causing extensive morbidity and mortality. These conditions are highly heterogeneous and require an early diagnosis. However, initial symptoms are nonspecific, and the clinical diagnosis is made late frequently. Over the last few years, personalized medicine has emerged as a medical care app...
Source: Advances in Protein Chemistry and Structural Biology - January 29, 2016 Category: Biochemistry Source Type: research

Chapter Four Clinical Perspectives on Targeting Therapies for Personalized Medicine
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 102 Author(s): Donald R.J. Singer, Zoulikha M. Zaïr Expected benefits from new technology include more efficient patient selection for clinical trials, more cost-effective treatment pathways for patients and health services and a more profitable accelerated approach for drug developers. Regulatory authorities expect the pharmaceutical and biotechnology industries to accelerate their development of companion diagnostics and companion therapeutics toward the goal of safer and more effective personalized medicine, and expect he...
Source: Advances in Protein Chemistry and Structural Biology - January 29, 2016 Category: Biochemistry Source Type: research

Chapter Three Metabolomics and Personalized Medicine
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 102 Author(s): Nadia Koen, Ilse Du Preez, Du Toit Loots Current clinical practice strongly relies on the prognosis, diagnosis, and treatment of diseases using methods determined and averaged for the specific diseased cohort/population. Although this approach complies positively with most patients, misdiagnosis, treatment failure, relapse, and adverse drug effects are common occurrences in many individuals, which subsequently hamper the control and eradication of a number of diseases. These incidences can be explained by ind...
Source: Advances in Protein Chemistry and Structural Biology - January 29, 2016 Category: Biochemistry Source Type: research

Chapter Two Role of Proteomics in the Development of Personalized Medicine
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 102 Author(s): Kewal K. Jain Advances in proteomic technologies have made import contribution to the development of personalized medicine by facilitating detection of protein biomarkers, proteomics-based molecular diagnostics, as well as protein biochips and pharmacoproteomics. Application of nanobiotechnology in proteomics, nanoproteomics, has further enhanced applications in personalized medicine. Proteomics-based molecular diagnostics will have an important role in the diagnosis of certain conditions and understanding the pa...
Source: Advances in Protein Chemistry and Structural Biology - January 29, 2016 Category: Biochemistry Source Type: research

Chapter One High-Performance Affinity Chromatography
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 102 Author(s): Zhao Li, Sandya R. Beeram, Cong Bi, D. Suresh, Xiwei Zheng, David S. Hage The binding of drugs with proteins and other agents in serum is of interest in personalized medicine because this process can affect the dosage and action of drugs. The extent of this binding may also vary with a given disease state. These interactions may involve serum proteins, such as human serum albumin or α1-acid glycoprotein, or other agents, such as lipoproteins. High-performance affinity chromatography (HPAC) is a tool th...
Source: Advances in Protein Chemistry and Structural Biology - January 29, 2016 Category: Biochemistry Source Type: research

SUMOylation and Potassium Channels: Links to Epilepsy and Sudden Death
Publication date: Available online 29 December 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Hongmei Wu, Xu Chen, Jinke Cheng, Yitao Qi Neuronal potassium ion channels play an essential role in the generation of the action potential and excitability of neurons. The dysfunction of ion channel subunits can cause channelopathies, which are associated in some cases with sudden unexplained death in epilepsy SUDEP. The physiological roles of neuronal ion channels have been largely determined, but little is known about the molecular mechanisms underlying neurological channelopathies, espe...
Source: Advances in Protein Chemistry and Structural Biology - January 15, 2016 Category: Biochemistry Source Type: research

Clinical Perspectives on Targeting Therapies for Personalized Medicine
Publication date: Available online 29 December 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Donald R.J. Singer, Zoulikha M. Zaïr Expected benefits from new technology include more efficient patient selection for clinical trials, more cost-effective treatment pathways for patients and health services and a more profitable accelerated approach for drug developers. Regulatory authorities expect the pharmaceutical and biotechnology industries to accelerate their development of companion diagnostics and companion therapeutics toward the goal of safer and more effective personalized medici...
Source: Advances in Protein Chemistry and Structural Biology - January 15, 2016 Category: Biochemistry Source Type: research

Role of Hemichannels in CNS Inflammation and the Inflammasome Pathway
Publication date: Available online 31 December 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Yuri Kim, Joanne O. Davidson, Katherine C. Gunn, Anthony R. Phillips, Colin R. Green, Alistair J. Gunn Neurodegenerative, cardiovascular, and metabolic disorders, once triggered, share a number of common features, including sustained inflammatory cell activation and vascular disruption. These shared pathways are induced independently of any genetic predisposition to the disease or the precise external stimulus. Glial cells respond to injury with an innate immune response that includes r...
Source: Advances in Protein Chemistry and Structural Biology - January 15, 2016 Category: Biochemistry Source Type: research

Personalized Medicine in Respiratory Disease: Role of Proteomics
Publication date: Available online 31 December 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): V.S. Priyadharshini, Luis M. Teran Respiratory diseases affect humanity globally, with chronic lung diseases (e.g., asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, among others) and lung cancer causing extensive morbidity and mortality. These conditions are highly heterogeneous and require an early diagnosis. However, initial symptoms are nonspecific, and the clinical diagnosis is made late frequently. Over the last few years, personalized medicine has emerged as a...
Source: Advances in Protein Chemistry and Structural Biology - January 15, 2016 Category: Biochemistry Source Type: research

Ion Channels in the Eye: Involvement in Ocular Pathologies
Publication date: Available online 31 December 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Jonathan P. Giblin, Nuria Comes, Olaf Strauss, Xavier Gasull The eye is the sensory organ of vision. There, the retina transforms photons into electrical signals that are sent to higher brain areas to produce visual sensations. In the light path to the retina, different types of cells and tissues are involved in maintaining the transparency of avascular structures like the cornea or lens, while others, like the retinal pigment epithelium, have a critical role in the maintenance of photorece...
Source: Advances in Protein Chemistry and Structural Biology - January 15, 2016 Category: Biochemistry Source Type: research

Polymodal Transient Receptor Potential Vanilloid Type 1 Nocisensor: Structure, Modulators, and Therapeutic Applications
Publication date: Available online 4 January 2016 Source:Advances in Protein Chemistry and Structural Biology Author(s): Minghua Cui, Vijayakumar Gosu, Shaherin Basith, Sunhye Hong, Sun Choi Transient receptor potential (TRP) channels belong to a superfamily of sensory-related ion channels responding to a wide variety of thermal, mechanical, or chemical stimuli. In an attempt to comprehend the piquancy and pain mechanism of the archetypal vanilloids, transient receptor potential vanilloid (TRPV) 1 was discovered. TRPV1, a well-established member of the TRP family, is implicated in a range of functions includi...
Source: Advances in Protein Chemistry and Structural Biology - January 15, 2016 Category: Biochemistry Source Type: research

P2X7 Receptor as a Therapeutic Target
Publication date: Available online 4 January 2016 Source:Advances in Protein Chemistry and Structural Biology Author(s): Elena De Marchi, Elisa Orioli, Diego Dal Ben, Elena Adinolfi P2X7 receptor is an ATP-gated cation channel that upon agonist interaction leads to cellular influx of Na+ and Ca2+ and efflux of K+. P2X7 is expressed by a wide variety of cells and its activation mediates a large number of biological processes like inflammation, neuromodulation, cell death or cell proliferation and it has been associated to related pathological conditions including infectious, inflammatory, autoimmune, neurologica...
Source: Advances in Protein Chemistry and Structural Biology - January 15, 2016 Category: Biochemistry Source Type: research