Advances in Protein Chemistry and Structural Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Chapter Seven Porous Alumina as a Promising Biomaterial for Public Health
Publication date: 2015 Source:Advances in Protein Chemistry and Structural Biology, Volume 101 Author(s): Nicola Luigi Bragazzi, Roberto Gasparini, Daniela Amicizia, Donatella Panatto, Claudio Larosa Porous aluminum is a nanostructured material characterized by unique properties, such as chemical stability, regular uniformity, dense hexagonal porous lattice with high aspect ratio nanopores, excellent mechanical strength, and biocompatibility. This overview examines how the structure and properties of porous alumina can be exploited in the field of public health. Porous alumina can be employed for fabricating ...
Source: Advances in Protein Chemistry and Structural Biology - November 15, 2015 Category: Biochemistry Source Type: research
Chapter Six Quartz-Crystal Microbalance (QCM) for Public Health
Publication date: 2015 Source:Advances in Protein Chemistry and Structural Biology, Volume 101 Author(s): Nicola Luigi Bragazzi, Daniela Amicizia, Donatella Panatto, Daniela Tramalloni, Ivana Valle, Roberto Gasparini Nanobiotechnologies, from the convergence of nanotechnology and molecular biology and postgenomics medicine, play a major role in the field of public health. This overview summarizes the potentiality of piezoelectric sensors, and in particular, of quartz-crystal microbalance (QCM), a physical nanogram-sensitive device. QCM enables the rapid, real time, on-site detection of pathogens with an eno...
Source: Advances in Protein Chemistry and Structural Biology - November 15, 2015 Category: Biochemistry Source Type: research
Chapter Five Evolution and Coevolution of PRC2 Genes in Vertebrates and Mammals
This study analyzes the evolution and coevolution of seven PRC2 genes in 29 Deuterostomia. These genes, previously assumed highly conserved, are found to have obtained multiple insertions in vertebrates and mammals and undergone significant positive selections in marsupials and prosimians, indicating adaptions to substantially increased lncRNAs (long noncoding RNAs) in mammals and in primates. Some insertions occur notably in homologous sequences of human nonsense-mediated decay (NMD) transcripts. Moreover, positive selections and signals of convergent evolution imply the independent increase of lncRNAs in mammals and in p...
Source: Advances in Protein Chemistry and Structural Biology - November 15, 2015 Category: Biochemistry Source Type: research
Chapter Four Alterations in Gene Expression in Depression
Publication date: 2015 Source:Advances in Protein Chemistry and Structural Biology, Volume 101 Author(s): Rossen Donev, Khaled Alawam The number of people around the world suffering from depression has dramatically increased in last few decades. It has been predicted that by 2020 depression will become the second most common cause of disability. Furthermore, depression is often misdiagnosed and confused with other psychiatric disorders showing similar symptoms, i.e., anxiety and bipolar disorder, due to the fact that diagnosing is often carried out by medical workers who are not psychiatrically trained. These facts...
Source: Advances in Protein Chemistry and Structural Biology - November 15, 2015 Category: Biochemistry Source Type: research
Chapter Three Telomere Repeat-Binding Factor 2 Is Responsible for the Telomere Attachment to the Nuclear Membrane
Publication date: 2015 Source:Advances in Protein Chemistry and Structural Biology, Volume 101 Author(s): Nadya V. Ilicheva, Olga I. Podgornaya, Alex P. Voronin Telomeres are nucleoprotein structures that specify ends of eukaryotic chromosomes. They enable complete DNA replication, protect chromosomes from end-to-end fusions, and help organize chromatin structure. These functions are mediated by special telomeric proteins. TRF2 (telomeric repeat-binding factor 2) is an essential component of shelterin, a telomere-binding protein complex. TRF2 induces formation of a special structure of telomeric DNA, counteracts ...
Source: Advances in Protein Chemistry and Structural Biology - November 15, 2015 Category: Biochemistry Source Type: research
Chapter Two Antitumor Lipids—Structure, Functions, and Medical Applications
Publication date: 2015 Source:Advances in Protein Chemistry and Structural Biology, Volume 101 Author(s): Aneliya Kostadinova, Tanya Topouzova-Hristova, Albena Momchilova, Rumiana Tzoneva, Martin R. Berger Cell proliferation and metastasis are considered hallmarks of tumor progression. Therefore, efforts have been made to develop novel anticancer drugs that inhibit both the proliferation and the motility of tumor cells. Synthetic antitumor lipids (ATLs), which are chemically divided into two main classes, comprise (i) alkylphospholipids (APLs) and (ii) alkylphosphocholines (APCs). They represent a new entity ...
Source: Advances in Protein Chemistry and Structural Biology - November 15, 2015 Category: Biochemistry Source Type: research
Chapter One The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer
Publication date: 2015 Source:Advances in Protein Chemistry and Structural Biology, Volume 101 Author(s): Sara Karaki, Claudia Andrieu, Hajer Ziouziou, Palma Rocchi Cancer cells depend on cap-dependent translation more than normal tissue. This explains the emergence of proteins involved in the cap-dependent translation as targets for potential anticancer drugs. Cap-dependent translation starts when eIF4E binds to mRNA cap domain. This review will present eIF4E's structure and functions. It will also expose the use of eIF4E as a therapeutic target in cancer. (Source: Advances in Protein Chemistry and Structural Biology)
Source: Advances in Protein Chemistry and Structural Biology - November 15, 2015 Category: Biochemistry Source Type: research
Role of Proteomics in the Development of Personalized Medicine
Publication date: Available online 11 November 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Kewal K. Jain Advances in proteomic technologies have made import contribution to the development of personalized medicine by facilitating detection of protein biomarkers, proteomics-based molecular diagnostics, as well as protein biochips and pharmacoproteomics. Application of nanobiotechnology in proteomics, nanoproteomics, has further enhanced applications in personalized medicine. Proteomics-based molecular diagnostics will have an important role in the diagnosis of certain conditions and und...
Source: Advances in Protein Chemistry and Structural Biology - November 12, 2015 Category: Biochemistry Source Type: research
Human Papillomavirus Vaccine: State of the Art and Future Perspectives
Publication date: Available online 11 November 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Donatella Panatto, Daniela Amicizia, Nicola Luigi Bragazzi, Emanuela Rizzitelli, Daniela Tramalloni, Ivana Valle, Roberto Gasparini Human Papillomavirus (HPV) is a widely distributed and common virus, that causes benign lesions (such as warts and papillomas) but, if not cleared, can lead to malignant lesions as well, such as intraepithelial lesions and neoplasia. An extensive body of researches has demonstrated that E1 and E2 are involved in viral transcription and replication, E5, E6...
Source: Advances in Protein Chemistry and Structural Biology - November 12, 2015 Category: Biochemistry Source Type: research
High-Performance Affinity Chromatography: Applications in Drug–Protein Binding Studies and Personalized Medicine
Publication date: Available online 3 November 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Zhao Li, Sandya R. Beeram, Cong Bi, D. Suresh, Xiwei Zheng, David S. Hage The binding of drugs with proteins and other agents in serum is of interest in personalized medicine because this process can affect the dosage and action of drugs. The extent of this binding may also vary with a given disease state. These interactions may involve serum proteins, such as human serum albumin or α1-acid glycoprotein, or other agents, such as lipoproteins. High-performance affinity chromatography (HP...
Source: Advances in Protein Chemistry and Structural Biology - November 5, 2015 Category: Biochemistry Source Type: research
Computational Approaches to Accelerating Novel Medicine and Better Patient Care from Bedside to Benchtop
Publication date: Available online 29 October 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Theodore Sakellaropoulos, Junguk Hur, Ioannis N. Melas, Ellen Y. Guo, Leonidas Alexopoulos, Mohammad Bohlooly, Jane P.F. Bai Some successes have been achieved in the war on cancer over the past 30 years with recent efforts on protein kinase inhibitors. Nonetheless, we are still facing challenges due to cancer evolution. Cancers are complex and heterogeneous due to primary and secondary mutations, with phenotypic and molecular heterogeneity manifested among patients of a cancer, and wit...
Source: Advances in Protein Chemistry and Structural Biology - October 31, 2015 Category: Biochemistry Source Type: research
Metabolomics and Personalized Medicine
Publication date: Available online 29 October 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Nadia Koen, Ilse Du Preez, Du Toit Loots Current clinical practice strongly relies on the prognosis, diagnosis, and treatment of diseases using methods determined and averaged for the specific diseased cohort/population. Although this approach complies positively with most patients, misdiagnosis, treatment failure, relapse, and adverse drug effects are common occurrences in many individuals, which subsequently hamper the control and eradication of a number of diseases. These incidences can be ...
Source: Advances in Protein Chemistry and Structural Biology - October 31, 2015 Category: Biochemistry Source Type: research
Investigating the Inhibitory Effect of Wortmannin in the Hotspot Mutation at Codon 1047 of PIK3CA Kinase Domain: A Molecular Docking and Molecular Dynamics Approach
Publication date: Available online 29 October 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): D. Thirumal Kumar, C. George Priya Doss Oncogenic mutations in phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) are the most frequently reported in association with various forms of cancer. Several studies have reported the significance of hotspot mutations in a catalytic subunit of PIK3CA in association with breast cancer. Mutations are frequently observed in the highly conserved region of the kinase domain (797–1068 amino acids) of PIK3CA are activating or gai...
Source: Advances in Protein Chemistry and Structural Biology - October 31, 2015 Category: Biochemistry Source Type: research
Telomere Repeat-Binding Factor 2 Is Responsible for the Telomere Attachment to the Nuclear Membrane
Publication date: Available online 21 October 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Nadya V. Ilicheva, Olga I. Podgornaya, Alex P. Voronin Telomeres are nucleoprotein structures that specify ends of eukaryotic chromosomes. They enable complete DNA replication, protect chromosomes from end-to-end fusions, and help organize chromatin structure. These functions are mediated by special telomeric proteins. TRF2 (telomeric repeat-binding factor 2) is an essential component of shelterin, a telomere-binding protein complex. TRF2 induces formation of a special structure of telomeric D...
Source: Advances in Protein Chemistry and Structural Biology - October 24, 2015 Category: Biochemistry Source Type: research
The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer
Publication date: Available online 23 October 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Sara Karaki, Claudia Andrieu, Hajer Ziouziou, Palma Rocchi Cancer cells depend on cap-dependent translation more than normal tissue. This explains the emergence of proteins involved in the cap-dependent translation as targets for potential anticancer drugs. Cap-dependent translation starts when eIF4E binds to mRNA cap domain. This review will present eIF4E's structure and functions. It will also expose the use of eIF4E as a therapeutic target in cancer. (Source: Advances in Protein Chemistry...
Source: Advances in Protein Chemistry and Structural Biology - October 24, 2015 Category: Biochemistry Source Type: research
