The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer

Publication date: Available online 23 October 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Sara Karaki, Claudia Andrieu, Hajer Ziouziou, Palma Rocchi Cancer cells depend on cap-dependent translation more than normal tissue. This explains the emergence of proteins involved in the cap-dependent translation as targets for potential anticancer drugs. Cap-dependent translation starts when eIF4E binds to mRNA cap domain. This review will present eIF4E's structure and functions. It will also expose the use of eIF4E as a therapeutic target in cancer.
Source: Advances in Protein Chemistry and Structural Biology - Category: Biochemistry Source Type: research