Advances in Protein Chemistry and Structural Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Oxidative Stress: Love and Hate History in Central Nervous System
Publication date: Available online 7 March 2017 Source:Advances in Protein Chemistry and Structural Biology Author(s): Genaro Gabriel Ortiz, Fermín P. Pacheco Moisés, Mario Mireles-Ramírez, Luis J. Flores-Alvarado, Héctor González-Usigli, Víctor J. Sánchez-González, Angélica L. Sánchez-López, Lorenzo Sánchez-Romero, Eduardo I. Díaz-Barba, J. Francisco Santoscoy-Gutiérrez, Paloma Rivero-Moragrega Molecular oxygen is essential for aerobic organisms in order to synthesize large amounts of energy during the process of oxidative phosphorylation and it is harnessed in the form of adenosine...
Source: Advances in Protein Chemistry and Structural Biology - March 7, 2017 Category: Biochemistry Source Type: research

Inflammation in Epileptic Encephalopathies
Publication date: Available online 28 February 2017 Source:Advances in Protein Chemistry and Structural Biology Author(s): Oleksii Shandra, Solomon L. Moshé, Aristea S. Galanopoulou West syndrome (WS) is an infantile epileptic encephalopathy that manifests with infantile spasms (IS), hypsarrhythmia (in ~60% of infants), and poor neurodevelopmental outcomes. The etiologies of WS can be structural–metabolic pathologies (~60%), genetic (12%–15%), or of unknown origin. The current treatment options include hormonal treatment (adrenocorticotropic hormone and high-dose steroids) and the GABA aminotransferase inhib...
Source: Advances in Protein Chemistry and Structural Biology - February 28, 2017 Category: Biochemistry Source Type: research

Chapter Nine Elucidating the Mutational Landscape in Hepatocyte Nuclear Factor 1 β (HNF1B) by Computational Approach
Publication date: 2017 Source:Advances in Protein Chemistry and Structural Biology, Volume 107 Author(s): P. Sneha, C.G.P. Doss Transcription factors are the major gene-regulatory proteins that recognize specific nucleotide sequences and bind to them. Missense mutations in transcription factors play a significant role in misregulation of gene expression contributing to various diseases and disorders. Understanding their structural and functional impact of the disease-causing mutations becomes prime importance in treating a disease. Commonly associated defect with the mutations of hepatocyte nuclear factor 1 beta (H...
Source: Advances in Protein Chemistry and Structural Biology - February 17, 2017 Category: Biochemistry Source Type: research

Chapter Eight Transcription Factors as a Target for Vaccination Against Ticks and Mites
Publication date: 2017 Source:Advances in Protein Chemistry and Structural Biology, Volume 107 Author(s): O.A.E. Sparagano Ticks and mites are well-known ectoparasites as potential vectors for numerous bacteria, viruses, and parasites. Many being blood feeders add to physiological deterioration, morbidity, and mortality of their vertebrate hosts. To control them, transcription factors have been identified and studied in their role to sustain such arthropod pests. This paper summarizes some of the work done on those factors involved during blood feeding, reproduction, or when interacting with their pathogens and symbi...
Source: Advances in Protein Chemistry and Structural Biology - February 17, 2017 Category: Biochemistry Source Type: research

Chapter Seven Transcription Factors in Breast Cancer —Lessons From Recent Genomic Analyses and Therapeutic Implications
Publication date: 2017 Source:Advances in Protein Chemistry and Structural Biology, Volume 107 Author(s): E. Zacksenhaus, J.C. Liu, Z. Jiang, Y. Yao, L. Xia, M. Shrestha, Y. Ben-David Multiplatform genomic analyses have identified 93 frequently altered genes in breast cancer. Of these, as many as 49 genes are directly or indirectly involved in transcription. These include constitutive and inducible DNA-binding transcription factors (DB-TFs, 13 genes), corepressors/coactivators (14 genes), epigenetic (10), and mediator/splicing/rRNA (3) factors. At least nine additional genes are immediate upstream regulat...
Source: Advances in Protein Chemistry and Structural Biology - February 17, 2017 Category: Biochemistry Source Type: research

Chapter Six The Complex Role of the ZNF224 Transcription Factor in Cancer
Publication date: 2017 Source:Advances in Protein Chemistry and Structural Biology, Volume 107 Author(s): E. Cesaro, G. Sodaro, G. Montano, M. Grosso, A. Lupo, P. Costanzo ZNF224 is a member of the Kruppel-associated box zinc finger proteins (KRAB-ZFPs) family. It was originally identified as a transcriptional repressor involved in gene-specific silencing through the recruitment of the corepressor KAP1, chromatin-modifying activities, and the arginine methyltransferase PRMT5 on the promoter of its target genes. Recent findings indicate that ZNF224 can behave both as a tumor suppressor or an oncogene in diff...
Source: Advances in Protein Chemistry and Structural Biology - February 17, 2017 Category: Biochemistry Source Type: research

Chapter Five The Functional Stability of FOXP3 and ROR γt in Treg and Th17 and Their Therapeutic Applications
Publication date: 2017 Source:Advances in Protein Chemistry and Structural Biology, Volume 107 Author(s): J. Ren, B. Li The balance of CD4+CD25+FOXP3+ regulatory T cells (Tregs) and effector T cells plays a key role in maintaining immune homeostasis, while the imbalance of them is related to many inflammatory diseases in both human and mice. Here we discuss about the plasticity of Tregs and Th17 cells, and the related human diseases resulted from the imbalance of them. Further, we will focus on the mechanisms regulating the plasticity between Tregs and Th17 cells and the potential therapeutic strategies by targetin...
Source: Advances in Protein Chemistry and Structural Biology - February 17, 2017 Category: Biochemistry Source Type: research

Chapter Four NF- κB as a Therapeutic Target in Inflammatory-Associated Bone Diseases
Publication date: 2017 Source:Advances in Protein Chemistry and Structural Biology, Volume 107 Author(s): T.-h. Lin, J. Pajarinen, L. Lu, A. Nabeshima, L.A. Cordova, Z. Yao, S.B. Goodman Inflammation is a defensive mechanism for pathogen clearance and maintaining tissue homeostasis. In the skeletal system, inflammation is closely associated with many bone disorders including fractures, nonunions, periprosthetic osteolysis (bone loss around orthopedic implants), and osteoporosis. Acute inflammation is a critical step for proper bone-healing and bone-remodeling processes. On the other hand, chronic inflamma...
Source: Advances in Protein Chemistry and Structural Biology - February 17, 2017 Category: Biochemistry Source Type: research

Chapter Three Targeting IKK and NF- κB for Therapy
Publication date: 2017 Source:Advances in Protein Chemistry and Structural Biology, Volume 107 Author(s): J.K. Durand, A.S. Baldwin In addition to regulating immune responses, the NF-κB family of transcription factors also promotes cellular proliferation and survival. NF-κB and its activating kinase, IKK, have become appealing therapeutic targets because of their critical roles in the progression of many diseases including chronic inflammation and cancer. Here, we discuss the conditions that lead to pathway activation, the effects of constitutive activation, and some of the strategies used to inhibit NF-κB signa...
Source: Advances in Protein Chemistry and Structural Biology - February 17, 2017 Category: Biochemistry Source Type: research

Chapter Two HMGB1 Protein
Publication date: 2017 Source:Advances in Protein Chemistry and Structural Biology, Volume 107 Author(s): I. Ugrinova, E. Pasheva High-mobility group box 1 protein (HMGB1) is a nonhistone chromosomal protein discovered more than 30 years ago. It is an abundant nuclear protein that has a dual function—in the nucleus, it binds DNA and participates in practically all DNA-dependent processes serving as an architectural factor. Outside the cell, HMGB1 plays a different role—it acts as an alarmine that activates a large number of HMGB1-“competent” cells and mediates a broad range of physiological and pathological...
Source: Advances in Protein Chemistry and Structural Biology - February 17, 2017 Category: Biochemistry Source Type: research

Chapter One Targeting Chromatin Remodeling in Inflammation and Fibrosis
We describe recent studies that have linked prolonged activation of the RelA–BRD4 pathway with the epithelial–mesenchymal transition (EMT) by inducing a core of EMT corepressors, stimulating secretion of growth factors promoting airway fibrosis. The mesenchymal state produces rewiring of the kinome and reprogramming of innate responses toward inflammation. In addition, the core regulator Zinc finger E-box homeodomain 1 (ZEB1) silences the expression of the interferon response factor 1 (IRF1), required for type III IFN expression. This epigenetic silencing is mediated by the Enhancer of Zeste 2 (EZH2) histone methyltran...
Source: Advances in Protein Chemistry and Structural Biology - February 17, 2017 Category: Biochemistry Source Type: research

Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy
Publication date: Available online 15 February 2017 Source:Advances in Protein Chemistry and Structural Biology Author(s): Jason Chua Min-Wen, Benjamin Chua Yan-Jiang, Srishti Mishra, Xiaoyun Dai, Junji Magae, Ng Shyh-Chang, Alan Prem Kumar, Gautam Sethi Cancer is an extremely complex disease comprising of a multitude of characteristic hallmarks that continue to evolve with time. At the genomic level, random mutations leading to deregulation of diverse oncogenic signal transduction cascades and polymorphisms coupled with environmental as well as life style-related factors are major causative agent contr...
Source: Advances in Protein Chemistry and Structural Biology - February 15, 2017 Category: Biochemistry Source Type: research

Stress-Adaptive Response in Ovarian Cancer Drug Resistance: Role of TRAP1 in Oxidative Metabolism-Driven Inflammation
Publication date: Available online 12 February 2017 Source:Advances in Protein Chemistry and Structural Biology Author(s): Maria Rosaria Amoroso, Danilo Swann Matassa, Ilenia Agliarulo, Rosario Avolio, Francesca Maddalena, Valentina Condelli, Matteo Landriscina, Franca Esposito Metabolic reprogramming is one of the most frequent stress-adaptive response of cancer cells to survive environmental changes and meet increasing nutrient requirements during their growth. These modifications involve cellular bioenergetics and cross talk with surrounding microenvironment, in a dynamic network that connect differe...
Source: Advances in Protein Chemistry and Structural Biology - February 13, 2017 Category: Biochemistry Source Type: research

Cardiokines as Modulators of Stress-Induced Cardiac Disorders
Publication date: Available online 10 February 2017 Source:Advances in Protein Chemistry and Structural Biology Author(s): Anna Planavila, Joaquim Fernández-Solà, Francesc Villarroya Almost 30 years ago, the protein, atrial natriuretic peptide, was identified as a heart-secreted hormone that provides a peripheral signal from the myocardium that communicates to the rest of the organism to modify blood pressure and volume under conditions of heart failure. Since then, additional peripheral factors secreted by the heart, termed cardiokines, have been identified and shown to coordinate this interorgan cross talk. I...
Source: Advances in Protein Chemistry and Structural Biology - February 10, 2017 Category: Biochemistry Source Type: research

Targeting IKK and NF- κB for Therapy
Publication date: Available online 11 January 2017 Source:Advances in Protein Chemistry and Structural Biology Author(s): J.K. Durand, A.S. Baldwin In addition to regulating immune responses, the NF-κB family of transcription factors also promotes cellular proliferation and survival. NF-κB and its activating kinase, IKK, have become appealing therapeutic targets because of their critical roles in the progression of many diseases including chronic inflammation and cancer. Here, we discuss the conditions that lead to pathway activation, the effects of constitutive activation, and some of the strategies used to inhi...
Source: Advances in Protein Chemistry and Structural Biology - January 11, 2017 Category: Biochemistry Source Type: research