Chapter Three Targeting IKK and NF- κB for Therapy

Publication date: 2017 Source:Advances in Protein Chemistry and Structural Biology, Volume 107 Author(s): J.K. Durand, A.S. Baldwin In addition to regulating immune responses, the NF-κB family of transcription factors also promotes cellular proliferation and survival. NF-κB and its activating kinase, IKK, have become appealing therapeutic targets because of their critical roles in the progression of many diseases including chronic inflammation and cancer. Here, we discuss the conditions that lead to pathway activation, the effects of constitutive activation, and some of the strategies used to inhibit NF-κB signaling.
Source: Advances in Protein Chemistry and Structural Biology - Category: Biochemistry Source Type: research