Advances in Protein Chemistry and Structural Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Chapter Five Vasoactive Intestinal Peptide (VIP) Nanoparticles for Diagnostics and for Controlled and Targeted Drug Delivery
Publication date: 2015 Source:Advances in Protein Chemistry and Structural Biology, Volume 98 Author(s): Rebecca Klippstein , David Pozo Neuropeptides are potentially valuable tools for clinical applications as they offer many distinct advantages over other bioactive molecules like proteins and monoclonal antibodies due to their reduced side effects and simple chemical modifications. Despite such advantages, the difficulty with neuropeptides often relies on their poor metabolic stability and reduced biological activity intervals. Among the neuropeptides, VIP has been identified as a potentially bioactive agent for in...
Source: Advances in Protein Chemistry and Structural Biology - March 27, 2015 Category: Biochemistry Source Type: research
Chapter Four Efficient Delivery of Therapeutic Agents by Using Targeted Albumin Nanoparticles
Publication date: 2015 Source:Advances in Protein Chemistry and Structural Biology, Volume 98 Author(s): Hasan Kouchakzadeh , Maryam Sadat Safavi , Seyed Abbas Shojaosadati Albumin nanoparticles are one of the most important drug carriers for the delivery of therapeutic drugs, especially for the treatment of malignancies. This potential is due to their high binding capacity for both hydrophobic and hydrophilic drugs and the possibility of surface modification. Accumulation of albumin-bound drugs in the tumor interstitium occurs by the enhanced permeability and retention effect, which is also facilitated by the 60-kD...
Source: Advances in Protein Chemistry and Structural Biology - March 27, 2015 Category: Biochemistry Source Type: research
Chapter Three Hybrid Protein–Synthetic Polymer Nanoparticles for Drug Delivery
Publication date: 2015 Source:Advances in Protein Chemistry and Structural Biology, Volume 98 Author(s): Neli S. Koseva , Joanna Rydz , Ekaterina V. Stoyanova , Violeta A. Mitova Among the most common nanoparticulate systems, the polymeric nanocarriers have a number of key benefits, which give a great choice of delivery platforms. Nevertheless, polymeric nanoparticles possess some limitations that include use of toxic solvents in the production process, polymer degradation, drug leakage outside the diseased tissue, and polymer cytotoxicity. The combination of polymers of biological and synthetic origin is an appeal...
Source: Advances in Protein Chemistry and Structural Biology - March 27, 2015 Category: Biochemistry Source Type: research
Chapter Two Modifications of Natural Peptides for Nanoparticle and Drug Design
Publication date: 2015 Source:Advances in Protein Chemistry and Structural Biology, Volume 98 Author(s): Andrew P. Jallouk , Rohun U. Palekar , Hua Pan , Paul H. Schlesinger , Samuel A. Wickline Natural products serve as an important source of novel compounds for drug development. Recently, peptides have emerged as a new class of therapeutic agents due to their versatility and specificity for biological targets. Yet, their effective application often requires use of a nanoparticle delivery system. In this chapter, we review the role of natural peptides in the design and creation of nanomedicines, with a particular...
Source: Advances in Protein Chemistry and Structural Biology - March 27, 2015 Category: Biochemistry Source Type: research
Chapter One Protein– and Peptide–Drug Conjugates An Emerging Drug Delivery Technology
Publication date: 2015 Source:Advances in Protein Chemistry and Structural Biology, Volume 98 Author(s): Imran Vhora , Sushilkumar Patil , Priyanka Bhatt , Ambikanandan Misra Protein– and peptide–drug conjugates hold a promising stance in the delivery of therapeutic agents by providing distinct advantage of improving therapeutic potential of drugs. Recent advancements in the proteomics and recombinant DNA technology, by enabling identification of distinct structural features of proteins and making it feasible to introduce specific functionalities in protein/peptide structure, has made it possible to synthesize ...
Source: Advances in Protein Chemistry and Structural Biology - March 27, 2015 Category: Biochemistry Source Type: research
Protein– and Peptide–Drug Conjugates: An Emerging Drug Delivery Technology
Publication date: Available online 14 March 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Imran Vhora , Sushilkumar Patil , Priyanka Bhatt , Ambikanandan Misra Protein– and peptide–drug conjugates hold a promising stance in the delivery of therapeutic agents by providing distinct advantage of improving therapeutic potential of drugs. Recent advancements in the proteomics and recombinant DNA technology, by enabling identification of distinct structural features of proteins and making it feasible to introduce specific functionalities in protein/peptide structure, has made it possible...
Source: Advances in Protein Chemistry and Structural Biology - March 16, 2015 Category: Biochemistry Source Type: research
Implications of Protein- and Peptide-Based Nanoparticles as Potential Vehicles for Anticancer Drugs
Publication date: Available online 12 March 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Ahmed O. Elzoghby , Mayada M. Elgohary , Nayra M. Kamel Protein-based nanocarriers have gained considerable attention as colloidal carrier systems for the delivery of anticancer drugs. Protein nanocarriers possess various advantages including their low cytotoxicity, abundant renewable sources, high drug-binding capacity, and significant uptake into the targeted tumor cells. Moreover, the unique protein structure offers the possibility of site-specific drug conjugation and tumor targeting using vari...
Source: Advances in Protein Chemistry and Structural Biology - March 14, 2015 Category: Biochemistry Source Type: research
Modifications of Natural Peptides for Nanoparticle and Drug Design
Publication date: Available online 12 March 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Andrew P. Jallouk , Rohun U. Palekar , Hua Pan , Paul H. Schlesinger , Samuel A. Wickline Natural products serve as an important source of novel compounds for drug development. Recently, peptides have emerged as a new class of therapeutic agents due to their versatility and specificity for biological targets. Yet, their effective application often requires use of a nanoparticle delivery system. In this chapter, we review the role of natural peptides in the design and creation of nanomedicines, wi...
Source: Advances in Protein Chemistry and Structural Biology - March 14, 2015 Category: Biochemistry Source Type: research
Hybrid Protein–Synthetic Polymer Nanoparticles for Drug Delivery
Publication date: Available online 13 March 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Neli S. Koseva , Joanna Rydz , Ekaterina V. Stoyanova , Violeta A. Mitova Among the most common nanoparticulate systems, the polymeric nanocarriers have a number of key benefits, which give a great choice of delivery platforms. Nevertheless, polymeric nanoparticles possess some limitations that include use of toxic solvents in the production process, polymer degradation, drug leakage outside the diseased tissue, and polymer cytotoxicity. The combination of polymers of biological and synthetic orig...
Source: Advances in Protein Chemistry and Structural Biology - March 14, 2015 Category: Biochemistry Source Type: research
Polysaccharide Nanoparticles for Protein and Peptide Delivery: Exploring Less-Known Materials
Publication date: Available online 3 March 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Marlise A. dos Santos , Ana Grenha Finding adequate carriers for protein and peptide delivery has become an urgent need, owing to the growing number of macromolecules identified as having therapeutic potential. Nanoparticles have emerged in the field as very promising vehicles and much work has been directed to testing the capacity of different materials to compose the matrix of these carriers. Natural materials and, specifically, polysaccharides have been taking the forefront of the challenge, becau...
Source: Advances in Protein Chemistry and Structural Biology - March 4, 2015 Category: Biochemistry Source Type: research
Vasoactive Intestinal Peptide (VIP) Nanoparticles for Diagnostics and for Controlled and Targeted Drug Delivery
Publication date: Available online 3 March 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Rebecca Klippstein , David Pozo Neuropeptides are potentially valuable tools for clinical applications as they offer many distinct advantages over other bioactive molecules like proteins and monoclonal antibodies due to their reduced side effects and simple chemical modifications. Despite such advantages, the difficulty with neuropeptides often relies on their poor metabolic stability and reduced biological activity intervals. Among the neuropeptides, VIP has been identified as a potentially bioactiv...
Source: Advances in Protein Chemistry and Structural Biology - March 4, 2015 Category: Biochemistry Source Type: research
Food-Grade Protein-Based Nanoparticles and Microparticles for Bioactive Delivery: Fabrication, Characterization, and Utilization
Publication date: Available online 3 March 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Gabriel Davidov-Pardo , Iris J. Joye , David Julian McClements Proteins can be used to fabricate nanoparticles and microparticles suitable for use as delivery systems for bioactive compounds in pharmaceutical, food, cosmetic, and other products. Food proteins originate from various animal or vegetal sources and exhibit a wide diversity of molecular and physicochemical characteristics, e.g., molecular weight, conformation, flexibility, polarity, charge, isoelectric point, solubility, and interactions...
Source: Advances in Protein Chemistry and Structural Biology - March 4, 2015 Category: Biochemistry Source Type: research
Efficient Delivery of Therapeutic Agents by Using Targeted Albumin Nanoparticles
Publication date: Available online 3 March 2015 Source:Advances in Protein Chemistry and Structural Biology Author(s): Hasan Kouchakzadeh , Maryam Sadat Safavi , Seyed Abbas Shojaosadati Albumin nanoparticles are one of the most important drug carriers for the delivery of therapeutic drugs, especially for the treatment of malignancies. This potential is due to their high binding capacity for both hydrophobic and hydrophilic drugs and the possibility of surface modification. Accumulation of albumin-bound drugs in the tumor interstitium occurs by the enhanced permeability and retention effect, which is also facilitate...
Source: Advances in Protein Chemistry and Structural Biology - March 4, 2015 Category: Biochemistry Source Type: research
Bioconjugation of Silk Fibroin Nanoparticles with Enzyme and Peptide and Their Characterization
In this study, we mixed the liquid silk solution with enzymes, including oxidase and hydrolase, and rapidly injected the mixture into an excess of acetone. The enzyme retained most of its enzymatic activity and was also captured in silk fibroin nanoparticles (SFNs), which instantly formed via a configuration transition of the regenerated silk protein from a random coil and α-helix to a β-sheet. The resulting enzyme-captured SFNs displayed a fine crystal structure with a high activity recovery and good thermal stability. Moreover, the affinities of these modified enzymes to their substrate did not evidently suffer from th...
Source: Advances in Protein Chemistry and Structural Biology - March 4, 2015 Category: Biochemistry Source Type: research
Chapter Five Monitoring the Biomolecular Interactions and the Activity of Zn-Containing Enzymes Involved in Conformational Diseases Experimental Methods for Therapeutic Purposes
Publication date: 2014 Source:Advances in Protein Chemistry and Structural Biology, Volume 97 Author(s): Giuseppe Grasso Zinc metalloproteases (ZnMPs) participate in diverse biological reactions, encompassing the synthesis and degradation of all the major metabolites in living organisms. In particular, ZnMPs have been recognized to play a very important role in controlling the concentration level of several peptides and/or proteins whose homeostasis has to be finely regulated for the correct physiology of cells. Dyshomeostasis of aggregation-prone proteins causes pathological conditions and the development of several ...
Source: Advances in Protein Chemistry and Structural Biology - November 29, 2014 Category: Biochemistry Source Type: research
