Advances in Protein Chemistry and Structural Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Chapter Three Polymodal Transient Receptor Potential Vanilloid Type 1 Nocisensor
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 104 Author(s): Minghua Cui, Vijayakumar Gosu, Shaherin Basith, Sunhye Hong, Sun Choi Transient receptor potential (TRP) channels belong to a superfamily of sensory-related ion channels responding to a wide variety of thermal, mechanical, or chemical stimuli. In an attempt to comprehend the piquancy and pain mechanism of the archetypal vanilloids, transient receptor potential vanilloid (TRPV) 1 was discovered. TRPV1, a well-established member of the TRP family, is implicated in a range of functions including inflammation...
Source: Advances in Protein Chemistry and Structural Biology - March 31, 2016 Category: Biochemistry Source Type: research

Chapter Two P2X7 Receptor as a Therapeutic Target
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 104 Author(s): Elena De Marchi, Elisa Orioli, Diego Dal Ben, Elena Adinolfi P2X7 receptor is an ATP-gated cation channel that upon agonist interaction leads to cellular influx of Na+ and Ca2+ and efflux of K+. P2X7 is expressed by a wide variety of cells and its activation mediates a large number of biological processes like inflammation, neuromodulation, cell death or cell proliferation and it has been associated to related pathological conditions including infectious, inflammatory, autoimmune, neurological, and musculos...
Source: Advances in Protein Chemistry and Structural Biology - March 31, 2016 Category: Biochemistry Source Type: research

Chapter One Role of Hemichannels in CNS Inflammation and the Inflammasome Pathway
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 104 Author(s): Yuri Kim, Joanne O. Davidson, Katherine C. Gunn, Anthony R. Phillips, Colin R. Green, Alistair J. Gunn Neurodegenerative, cardiovascular, and metabolic disorders, once triggered, share a number of common features, including sustained inflammatory cell activation and vascular disruption. These shared pathways are induced independently of any genetic predisposition to the disease or the precise external stimulus. Glial cells respond to injury with an innate immune response that includes release of proinfl...
Source: Advances in Protein Chemistry and Structural Biology - March 31, 2016 Category: Biochemistry Source Type: research

Contribution of Automated Technologies to Ion Channel Drug Discovery
Publication date: Available online 3 March 2016 Source:Advances in Protein Chemistry and Structural Biology Author(s): Arturo Picones, Arlet Loza-Huerta, Pedro Segura-Chama, Cesar O. Lara-Figueroa Automated technologies are now resolving the historical relegation that ion channels have endured as targets for the new drug discovery and development global efforts. The richness and adequacy of functional assay methodologies, remarkably fluorescence-based detection of ions fluxes and patch-clamp electrophysiology recording of ionic currents, are now automated and increasingly employed for the analysis of ion channe...
Source: Advances in Protein Chemistry and Structural Biology - March 3, 2016 Category: Biochemistry Source Type: research

Chapter Eight SUMOylation and Potassium Channels
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 103 Author(s): Hongmei Wu, Xu Chen, Jinke Cheng, Yitao Qi Neuronal potassium ion channels play an essential role in the generation of the action potential and excitability of neurons. The dysfunction of ion channel subunits can cause channelopathies, which are associated in some cases with sudden unexplained death in epilepsy SUDEP. The physiological roles of neuronal ion channels have been largely determined, but little is known about the molecular mechanisms underlying neurological channelopathies, especially the determ...
Source: Advances in Protein Chemistry and Structural Biology - February 24, 2016 Category: Biochemistry Source Type: research

Chapter Seven pH-Sensitive K+ Currents and Properties of K2P Channels in Murine Hippocampal Astrocytes
In conclusion, the assembly of astrocytic K+ channels allows tolerating short, transient acidification, and glial Kir4.1 and K2P channels can be considered promising new targets in brain diseases accompanied by pH shifts. (Source: Advances in Protein Chemistry and Structural Biology)
Source: Advances in Protein Chemistry and Structural Biology - February 24, 2016 Category: Biochemistry Source Type: research

Chapter Six AMPA Receptors as Therapeutic Targets for Neurological Disorders
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 103 Author(s): Kevin Lee, Lucy Goodman, Chantelle Fourie, Susan Schenk, Beulah Leitch, Johanna M. Montgomery Almost every neurological disease directly or indirectly affects synapse function in the brain. However, these diseases alter synapses through different mechanisms, ultimately resulting in altered synaptic transmission and/or plasticity. Glutamate is the major neurotransmitter that mediates excitatory synaptic transmission in the brain through activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate ...
Source: Advances in Protein Chemistry and Structural Biology - February 24, 2016 Category: Biochemistry Source Type: research

Chapter Five Glutamatergic NMDA Receptor as Therapeutic Target for Depression
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 103 Author(s): Gislaine Z. Réus, Helena M. Abelaira, Talita Tuon, Stephanie E. Titus, Zuleide M. Ignácio, Ana Lúcia S. Rodrigues, João Quevedo Major depressive disorder (MDD) affects approximately 121 million individuals globally and poses a significant burden to the healthcare system. Around 50–60% of patients with MDD respond adequately to existing treatments that are primarily based on a monoaminergic system. However, the neurobiology of MDD has not been fully elucidated; therefore, it is possible that othe...
Source: Advances in Protein Chemistry and Structural Biology - February 24, 2016 Category: Biochemistry Source Type: research

Chapter Four Acid-Sensing Ion Channels as Potential Pharmacological Targets in Peripheral and Central Nervous System Diseases
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 103 Author(s): Beatrice Mihaela Radu, Adela Banciu, Daniel Dumitru Banciu, Mihai Radu Acid-sensing ion channels (ASICs) are widely expressed in the body and represent good sensors for detecting protons. The pH drop in the nervous system is equivalent to ischemia and acidosis, and ASICs are very good detectors in discriminating slight changes in acidity. ASICs are important pharmacological targets being involved in a variety of pathophysiological processes affecting both the peripheral nervous system (e.g., peripheral pain...
Source: Advances in Protein Chemistry and Structural Biology - February 24, 2016 Category: Biochemistry Source Type: research

Chapter Three Ion Channels in Neurological Disorders
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 103 Author(s): Pravir Kumar, Dhiraj Kumar, Saurabh Kumar Jha, Niraj Kumar Jha, Rashmi K. Ambasta The convergent endeavors of the neuroscientist to establish a link between clinical neurology, genetics, loss of function of an important protein, and channelopathies behind neurological disorders are quite intriguing. Growing evidence reveals the impact of ion channels dysfunctioning in neurodegenerative disorders (NDDs). Many neurological/neuromuscular disorders, viz, Alzheimer's disease, Parkinson's disease, Huntington's ...
Source: Advances in Protein Chemistry and Structural Biology - February 24, 2016 Category: Biochemistry Source Type: research

Chapter Two Harnessing the Flow of Excitation
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 103 Author(s): Roman V. Frolov, Matti Weckström Cellular signaling in both excitable and nonexcitable cells involves several classes of ion channels. Some of them are of minor importance, with very specialized roles in physiology, but here we concentrate on three major channel classes: TRP (transient receptor potential channels), voltage-gated sodium channels (Nav), and voltage-gated calcium channels (Cav). Here, we first propose a conceptual framework binding together all three classes of ion channels, a “flow-of-excitati...
Source: Advances in Protein Chemistry and Structural Biology - February 24, 2016 Category: Biochemistry Source Type: research

Chapter One Proteostasis Maintenance of Cys-Loop Receptors
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 103 Author(s): Yan-Lin Fu, Ya-Juan Wang, Ting-Wei Mu The Cys-loop receptors play prominent roles in the nervous system. They include γ-aminobutyric acid type A receptors, nicotinic acetylcholine receptors, 5-hydroxytryptamine type-3 receptors, and glycine receptors. Proteostasis represents an optimal state of the cellular proteome in normal physiology. The proteostasis network regulates the folding, assembly, degradation, and trafficking of the Cys-loop receptors, ensuring their efficient functional cell surface expression...
Source: Advances in Protein Chemistry and Structural Biology - February 24, 2016 Category: Biochemistry Source Type: research

TRPM8 Ion Channels as Potential Cancer Biomarker and Target in Pancreatic Cancer
This article provides a review and discussion of the transient receptor potential melastatin-subfamily member 8 (TRPM8) ion channel as a potential biomarker and target in cancer. TRPM8 is a Ca2+-permeable channel that plays a major physiological role in cellular sensation and transduction of cold temperature. TRPM8 is aberrantly expressed in a variety of solid tumors including pancreatic cancer. In pancreatic adenocarcinoma cell lines and tissues, TRPM8 is overexpressed as compared to normal pancreatic ductal epithelia. Analysis of anti-TRPM8 immunoreactivity in pancreatic adenocarcinoma indicates positive correlation of T...
Source: Advances in Protein Chemistry and Structural Biology - February 22, 2016 Category: Biochemistry Source Type: research

Chapter Ten Role of von Willebrand Factor—A1 Domain Variants P1266L, H1268D, C1272R, and C1272F in VWD
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 102 Author(s): C. George Priya Doss, Shabana Kouser Ali von Willebrand disease (VWD) is an autosomal inherited disorder related to trauma-related bleeding in affected people. VWD results from deficiency of von Willebrand factor (VWF)—a glycoprotein involved in hemostasis and carrier for factor VIII (FVIII). Mutations in A1 domain of von Willebrand factor (VWD) gene are exceptionally polymorphic and associated with adhesion movement, clearance, and binding properties that could be interfaced with thrombosis. To address this ...
Source: Advances in Protein Chemistry and Structural Biology - January 29, 2016 Category: Biochemistry Source Type: research

Chapter Nine Investigating the Inhibitory Effect of Wortmannin in the Hotspot Mutation at Codon 1047 of PIK3CA Kinase Domain
Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 102 Author(s): D. Thirumal Kumar, C. George Priya Doss Oncogenic mutations in phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) are the most frequently reported in association with various forms of cancer. Several studies have reported the significance of hotspot mutations in a catalytic subunit of PIK3CA in association with breast cancer. Mutations are frequently observed in the highly conserved region of the kinase domain (797–1068 amino acids) of PIK3CA are activating or gain-of-function mu...
Source: Advances in Protein Chemistry and Structural Biology - January 29, 2016 Category: Biochemistry Source Type: research