Advances in Protein Chemistry and Structural Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Therapeutic Monoclonal Antibodies Delivery for the Glioblastoma Treatment
Publication date: Available online 30 March 2018 Source:Advances in Protein Chemistry and Structural Biology Author(s): Flávia Sousa, Rui P. Moura, Elias Moreira, Cláudia Martins, Bruno Sarmento Glioblastoma multiforme (GBM) is the most common and challenging primary malignant brain tumor, being the median overall survival between 10 and 14 months due to its invasive characteristics. GBM treatment is mainly based on the maximal surgical resection and radiotherapy associated to chemotherapy. Monoclonal antibodies (mAbs) have been used in chemotherapy protocols for GBM treatment in order to improve immunother...
Source: Advances in Protein Chemistry and Structural Biology - March 31, 2018 Category: Biochemistry Source Type: research

Computational Methods to Discover Compounds for the Treatment of Chagas Disease
Publication date: Available online 16 March 2018 Source:Advances in Protein Chemistry and Structural Biology Author(s): Eduardo M. Cortés-Ruiz, Oscar Palomino-Hernández, Karla Daniela Rodríguez-Hernández, Bertha Espinoza, José L. Medina-Franco Infectious diseases continue to be a major public health. Among these diseases, American trypanosomiasis or Chagas disease (CD) is a major cause of morbidity and death for millions of people in Latin America. The two drugs currently available for the treatment of CD have poor efficacy and major side effects. Thus, there is a pressing need to develop safe and effect...
Source: Advances in Protein Chemistry and Structural Biology - March 17, 2018 Category: Biochemistry Source Type: research

In Silico Tools and Databases for Designing Peptide-Based Vaccine and Drugs
Publication date: Available online 5 March 2018 Source:Advances in Protein Chemistry and Structural Biology Author(s): Salman Sadullah Usmani, Rajesh Kumar, Sherry Bhalla, Vinod Kumar, Gajendra P.S. Raghava The prolonged conventional approaches of drug screening and vaccine designing prerequisite patience, vigorous effort, outrageous cost as well as additional manpower. Screening and experimentally validating thousands of molecules for a specific therapeutic property never proved to be an easy task. Similarly, traditional way of vaccination includes administration of either whole or attenuated pathogen, which...
Source: Advances in Protein Chemistry and Structural Biology - March 7, 2018 Category: Biochemistry Source Type: research

Rational Design of Liquid Formulations of Proteins
The objective of this review is to lay out four concepts that will guide one to obtaining a stable liquid protein formulation. Additionally, the aim will be to identify factors that are intrinsic to the stabilization of any protein, not just a particular class of proteins, such as monoclonal antibodies (Uchiyama, 2014; Wang, Singh, Zeng, King, & Nema, 2007) and to provide guidelines aiming to effect stabilization. Noting that all approaches to stabilization face validation that must be performed empirically, it is hoped that the rational strategies described here will help the formulation scientist in their daily t...
Source: Advances in Protein Chemistry and Structural Biology - March 7, 2018 Category: Biochemistry Source Type: research

Computational Methods for Epigenetic Drug Discovery: A Focus on Activity Landscape Modeling
Publication date: Available online 5 March 2018 Source:Advances in Protein Chemistry and Structural Biology Author(s): J. Jesús Naveja, C. Iluhí Oviedo-Osornio, José L. Medina-Franco Epigenetic drug discovery is an emerging strategy against several chronic and complex diseases. The increased interest in epigenetics has boosted the development and maintenance of large information on structure–epigenetic activity relationships for several epigenetic targets. In turn, such large databases—many in the public domain—are a rich source of information to explore their structure–activity relationships (SARs). H...
Source: Advances in Protein Chemistry and Structural Biology - March 7, 2018 Category: Biochemistry Source Type: research

Peptide Derivatives of Erythropoietin in the Treatment of Neuroinflammation and Neurodegeneration
Publication date: Available online 28 February 2018 Source:Advances in Protein Chemistry and Structural Biology Author(s): Ilkcan Ercan, Kemal Ugur Tufekci, Ezgi Karaca, Sermin Genc, Kursad Genc During the past 35 years, recombinant DNA technology has allowed the production of a wide range of hematopoietic and neurotrophic growth factors including erythropoietin (EPO). These have emerged as promising protein drugs in various human diseases. Accumulated evidences have recently demonstrated the neuroprotective effect of EPO in preclinical models of acute and chronic degenerative disorders. Nevertheless, tissue ...
Source: Advances in Protein Chemistry and Structural Biology - March 1, 2018 Category: Biochemistry Source Type: research

Smart Cell-Penetrating Peptide-Based Techniques for Intracellular Delivery of Therapeutic Macromolecules
Publication date: Available online 26 February 2018 Source:Advances in Protein Chemistry and Structural Biology Author(s): Yang He, Feng Li, Yongzhuo Huang Many therapeutic macromolecules must enter cells to take their action. However, their treatment outcomes are often hampered by their poor transportation into target cells. Therefore, efficient intracellular delivery of these macromolecules is critical for improving their therapeutic efficacy. Cell-penetrating peptide (CPP)-based approaches are one of the most efficient methods for intracellular delivery of macromolecular therapeutics. Nevertheless, poor specif...
Source: Advances in Protein Chemistry and Structural Biology - February 28, 2018 Category: Biochemistry Source Type: research

Dynamical Behavior of Somatostatin-14 and Its Cyclic Analogues as Analyzed in Bulk and on Plasmonic Silver Nanoparticles
Publication date: Available online 23 February 2018 Source:Advances in Protein Chemistry and Structural Biology Author(s): Belén Hernández, Yves-Marie Coïc, Eduardo López-Tobar, Santiago Sanchez-Cortes, Bruno Baron, Fernando Pflüger, Sergei G. Kruglik, Régis Cohen, Mahmoud Ghomi Primarily known as the inhibitor of growth hormone release, the role of somatostatin in many other inhibiting activities upon binding to its five G-protein-coupled receptors has been elucidated. Because of the short half-life of somatostatin, a number of synthetic analogues were elaborated for this peptide hormone. Herei...
Source: Advances in Protein Chemistry and Structural Biology - February 24, 2018 Category: Biochemistry Source Type: research

The Structure/Function Relationship in Antimicrobial Peptides: What Can we Obtain From Structural Data?
Publication date: Available online 23 February 2018 Source:Advances in Protein Chemistry and Structural Biology Author(s): Marlon H. Cardoso, Karen G.N. Oshiro, Samilla B. Rezende, Elizabete S. Cândido, Octávio L. Franco Antimicrobial peptides (AMPs) have been widely isolated from most organisms in nature. This class of antimicrobials may undergo changes in their sequence for improved physicochemical properties, including charge, hydrophobicity, and hydrophobic moment. It is known that such properties may be directly associated with AMPs’ structural arrangements and, consequently, could interfere in their...
Source: Advances in Protein Chemistry and Structural Biology - February 23, 2018 Category: Biochemistry Source Type: research

Chapter Nine Human Interactomics: Comparative Analysis of Different Protein Interaction Resources and Construction of a Cancer Protein –Drug Bipartite Network
Publication date: 2018 Source:Advances in Protein Chemistry and Structural Biology, Volume 111 Author(s): Javier De Las Rivas, Diego Alonso-López, Mónica M. Arroyo Unraveling the protein interaction wiring that occurs in human cells as a scaffold of biological processes requires the identification of all elements that constitute such molecular interaction networks. Proteome-wide experimental studies and bioinformatic comprehensive efforts have provided reliable and updated compendiums of the human protein interactome. In this work, we present a current view of available databases of human protein–protein inte...
Source: Advances in Protein Chemistry and Structural Biology - February 16, 2018 Category: Biochemistry Source Type: research

Chapter Eight Investigating the Influence of Hotspot Mutations in Protein –Protein Interaction of IDH1 Homodimer Protein: A Computational Approach
In this study, we have used extensive computational approaches to identify the impact of missense mutations (R132C, R132G, R132H, R132L, R132S, and V178I) occurring in the interacting region of the IDH1 homodimer. By in silico pathogenicity analysis, all the mutations occurring at the positions 132 and 178 were found to be pathogenic and neutral respectively. Furthermore, the mutants R132C and R132G were found to be responsible for increasing the stability, whereas the mutants R132H, R132L, and R132S were found to be responsible for the decrease in stability by stability analysis. R132H, R132L, and R132S mutants exhibited ...
Source: Advances in Protein Chemistry and Structural Biology - February 16, 2018 Category: Biochemistry Source Type: research

Chapter Seven Defining Pharmacological Targets by Analysis of Virus –Host Protein Interactions
Publication date: 2018 Source:Advances in Protein Chemistry and Structural Biology, Volume 111 Author(s): Manuel Llano, Mario A. Peña-Hernandez Viruses are obligate parasites that depend on cellular factors for replication. Pharmacological inhibition of essential viral proteins, mostly enzymes, is an effective therapeutic alternative in the absence of effective vaccines. However, this strategy commonly encounters drug resistance mechanisms that allow these pathogens to evade control. Due to the dependency on host factors for viral replication, pharmacological disruption of the host-pathogen protein–protein inter...
Source: Advances in Protein Chemistry and Structural Biology - February 16, 2018 Category: Biochemistry Source Type: research

Chapter Six Development of Protein –Protein Interaction Inhibitors for the Treatment of Infectious Diseases
Publication date: 2018 Source:Advances in Protein Chemistry and Structural Biology, Volume 111 Author(s): Andrew F. Voter, James L. Keck Protein–protein interaction (PPI) inhibitors are a rapidly expanding class of therapeutics. Recent advances in our understanding of PPIs and success of early examples of PPI inhibitors demonstrate the feasibility of targeting PPIs. This review summarizes the techniques used for the discovery and optimization of a diverse set PPI inhibitors, focusing on the development of PPI inhibitors as new antibacterial and antiviral agents. We close with a summary of the advances responsible...
Source: Advances in Protein Chemistry and Structural Biology - February 16, 2018 Category: Biochemistry Source Type: research

Chapter Five Subcellular Targeting of Nitric Oxide Synthases Mediated by Their N-Terminal Motifs
Publication date: 2018 Source:Advances in Protein Chemistry and Structural Biology, Volume 111 Author(s): Carlos Costas-Insua, Javier Merino-Gracia, Clara Aicart-Ramos, Ignacio Rodríguez-Crespo From a catalytic point of view, the three mammalian nitric oxide synthases (NOSs) function in an almost identical way. The N-terminal oxygenase domain catalyzes the conversion of l-arginine to l-citrulline plus ·NO in two sequential oxidation steps. Once l-arginine binds to the active site positioned above the heme moiety, two consecutive monooxygenation reactions take place. In the first step, l-arginine is hydroxylat...
Source: Advances in Protein Chemistry and Structural Biology - February 16, 2018 Category: Biochemistry Source Type: research

Chapter Four Multifaceted Nucleolin Protein and Its Molecular Partners in Oncogenesis
Publication date: 2018 Source:Advances in Protein Chemistry and Structural Biology, Volume 111 Author(s): Iva Ugrinova, Maria Petrova, Mounira Chalabi-Dchar, Philippe Bouvet Discovered in 1973, nucleolin is one of the most abundant phosphoproteins of the nucleolus. The ability of nucleolin to be involved in many cellular processes is probably related to its structural organization and its capability to form many different interactions with other proteins. Many functions of nucleolin affect cellular processes involved in oncogenesis—for instance: in ribosome biogenesis; in DNA repair, remodeling, and genome st...
Source: Advances in Protein Chemistry and Structural Biology - February 16, 2018 Category: Biochemistry Source Type: research