The Functional Stability of FOXP3 and ROR γt in Treg and Th17 and Their Therapeutic Applications

Publication date: Available online 15 December 2016 Source:Advances in Protein Chemistry and Structural Biology Author(s): J. Ren, B. Li The balance of CD4+CD25+FOXP3+ regulatory T cells (Tregs) and effector T cells plays a key role in maintaining immune homeostasis, while the imbalance of them is related to many inflammatory diseases in both human and mice. Here we discuss about the plasticity of Tregs and Th17 cells, and the related human diseases resulted from the imbalance of them. Further, we will focus on the mechanisms regulating the plasticity between Tregs and Th17 cells and the potential therapeutic strategies by targeting regulators of the expression and activity of FOXP3 and RORĪ³t or regulators of Treg/Th17 balance in autoimmune diseases, allergy, infection, and cancer.
Source: Advances in Protein Chemistry and Structural Biology - Category: Biochemistry Source Type: research