Metformin influences drug sensitivity in pancreatic cancer cells
Publication date: May 2018Source: Advances in Biological Regulation, Volume 68Author(s): Saverio Candido, Stephen L. Abrams, Linda Steelman, Kvin Lertpiriyapong, Alberto M. Martelli, Lucio Cocco, Stefano Ratti, Matilde Y. Follo, Ramiro M. Murata, Pedro L. Rosalen, Paolo Lombardi, Giuseppe Montalto, Melchiorre Cervello, Agnieszka Gizak, Dariusz Rakus, Pann-Gill Suh, Massimo Libra, James A. McCubreyAbstractPancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five-year survival of only 5–10% after diagnosis...
Source: Advances in Biological Regulation - July 5, 2018 Category: Biology Source Type: research
Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases
Publication date: May 2018Source: Advances in Biological Regulation, Volume 68Author(s): Suyong Choi, Xander Houdek, Richard A. AndersonAbstractPhosphatidylinositol phosphate kinases (PIPKs) generate a lipid messenger phosphatidylinositol 4,5-bisphosphate (PI4,5P2) that controls essentially all aspects of cellular functions. PI4,5P2 rapidly diffuses in the membrane of the lipid bilayer and does not greatly change in membrane or cellular content, and thus PI4,5P2 generation by PIPKs is tightly linked to its usage in subcellular compartments. Based on this verity, recent study of PI4,5P2 signal transduction has been focused ...
Source: Advances in Biological Regulation - July 5, 2018 Category: Biology Source Type: research
The inflammatory microenvironment that promotes gastrointestinal cancer development and invasion
Publication date: May 2018Source: Advances in Biological Regulation, Volume 68Author(s): Kanae Echizen, Hiroko Oshima, Mizuho Nakayama, Masanobu OshimaAbstractAccumulating evidence has indicated that the inflammatory response is important for tumor promotion. However, the mechanisms underlying the induction of the inflammatory response in cancer tissues and how it promotes tumorigenesis remain poorly understood. We constructed several mouse models that develop inflammation-associated gastric and intestinal tumors and examined the in vivo mechanisms of tumorigenesis. Of note, the activation of cyclooxygenase-2 (COX-2)/prost...
Source: Advances in Biological Regulation - July 5, 2018 Category: Biology Source Type: research
Interaction of the Wnt/β-catenin and RAS-ERK pathways involving co-stabilization of both β-catenin and RAS plays important roles in the colorectal tumorigenesis
Publication date: May 2018Source: Advances in Biological Regulation, Volume 68Author(s): Sang-Kyu Lee, Jeong-Ha Hwang, Kang-Yell ChoiAbstractCancer development is usually driven by multiple genetic and molecular alterations rather than by a single defect. In the human colorectal cancer (CRC), series of mutations of genes are involved in the different stages of tumorigenesis. For example, adenomatous polyposis coli (APC) and KRAS mutations have been known to play roles in the initiation and progression of the tumorigenesis, respectively. However, many studies indicate that mutations of these two genes, which play roles in t...
Source: Advances in Biological Regulation - July 5, 2018 Category: Biology Source Type: research
Disrupting the ‘Warburg effect’ re-routes cancer cells to OXPHOS offering a vulnerability point via ‘ferroptosis’-induced cell death
Publication date: May 2018Source: Advances in Biological Regulation, Volume 68Author(s): Maša Ždralević, Milica Vučetić, Boutaina Daher, Ibtissam Marchiq, Scott K. Parks, Jacques PouysségurAbstractThe evolution of life from extreme hypoxic environments to an oxygen-rich atmosphere has progressively selected for successful metabolic, enzymatic and bioenergetic networks through which a myriad of organisms survive the most extreme environmental conditions. From the two lethal environments anoxia/high O2, cells have developed survival strategies through expression of the transcriptional factors ATF4, HIF1 and NRF2. Cance...
Source: Advances in Biological Regulation - July 5, 2018 Category: Biology Source Type: research
Nuclear organization mediates cancer-compromised genetic and epigenetic control
Publication date: Available online 9 May 2018Source: Advances in Biological RegulationAuthor(s): Sayyed K. Zaidi, Andrew J. Fritz, Kirsten M. Tracy, Jonathan A. Gordon, Coralee E. Tye, Joseph Boyd, Andre J. Van Wijnen, Jeffrey A. Nickerson, Antony N. Imbalzano, Jane B. Lian, Janet L. Stein, Gary S. SteinAbstractNuclear organization is functionally linked to genetic and epigenetic regulation of gene expression for biological control and is modified in cancer. Nuclear organization supports cell growth and phenotypic properties of normal and cancer cells by facilitating physiologically responsive interactions of chromosomes, ...
Source: Advances in Biological Regulation - July 5, 2018 Category: Biology Source Type: research
Roles of p53, NF-κB and the androgen receptor in controlling NGAL expression in prostate cancer cell lines
Publication date: Available online 18 May 2018Source: Advances in Biological RegulationAuthor(s): William H. Chappell, Saverio Candido, Stephen L. Abrams, Suzanne Russo, Roger Ove, Alberto M. Martelli, Lucio Cocco, Giulia Ramazzotti, Melchiorre Cervello, Giuseppe Montalto, Linda S. Steelman, Xiaohong Leng, Ralph B. Arlinghaus, Massimo Libra, James A. McCubreyAbstractNeutrophil gelatinase-associated lipocalin (NGAL a.k.a lipocalin 2, lnc2) is a secreted protein which can form a complex with matrix metalloproteinase-9 (MMP9). This MMP9/NGAL complex has been associated with metastasis. MMP9 and NGAL are detected in the urine ...
Source: Advances in Biological Regulation - July 5, 2018 Category: Biology Source Type: research
Systematic analysis of GSK-3 signaling pathways in aging of cerebral tissue
Publication date: Available online 21 June 2018Source: Advances in Biological RegulationAuthor(s): D. Drulis-Fajdasz, D. Rakus, J.R. Wiśniewski, J.A. McCubrey, A. GizakAbstractGlycogen synthase kinase-3 (GSK-3) is a constitutively active kinase, involved in regulation of multiple physiological processes. In brain, changes in GSK-3 signaling are related to neurodegenerative issues, including Alzheimer's disease. Due to the wide range of GSK-3 cellular targets, a therapeutic use of the enzyme inhibitors entails significant risk of side effects. Thus, altering the ratio of specific pool of GSK-3 or specific substrates instea...
Source: Advances in Biological Regulation - July 5, 2018 Category: Biology Source Type: research
The regulation of normal and neoplastic hematopoiesis is dependent on microenvironmental cells
Publication date: Available online 27 June 2018Source: Advances in Biological RegulationAuthor(s): Kenneth Kaushansky, Huichun ZhanAbstractEach day the adult human produces 4 × 1011 red blood cells, 1 × 1011 white blood cells and 1 × 1011 platelets, levels of production which can increase 10–20 fold in times of heightened demand. Hematopoiesis, or the formation of the ten different types of blood and marrow cells, is a complex process involving hematopoietic stem cells (HSCs), cytokine growth factors and cell surface adhesion molecules, and both specific and ubiquitous transcription factors. The marrow mic...
Source: Advances in Biological Regulation - July 5, 2018 Category: Biology Source Type: research
Introduction of WT-TP53 into pancreatic cancer cells alters sensitivity to chemotherapeutic drugs, targeted therapeutics and nutraceuticals
Publication date: Available online 28 June 2018Source: Advances in Biological RegulationAuthor(s): Stephen L. Abrams, Kvin Lertpiriyapong, Li V. Yang, Alberto M. Martelli, Lucio Cocco, Stefano Ratti, Marco Falasca, Ramiro M. Murata, Pedro L. Rosalen, Paolo Lombardi, Massimo Libra, Saverio Candido, Giuseppe Montalto, Melchiorre Cervello, Linda S. Steelman, James A. McCubreyAbstractPancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five-year survival of only 5–10%. Mutations at the TP53 gene are readily ...
Source: Advances in Biological Regulation - July 5, 2018 Category: Biology Source Type: research
Introduction of WT-TP53 into pancreatic cancer cells alters sensitivity to chemotherapeutic drugs, targeted therapeutics and nutraceuticals
Publication date: Available online 28 June 2018 Source:Advances in Biological Regulation Author(s): Stephen L. Abrams, Kvin Lertpiriyapong, Li V. Yang, Alberto M. Martelli, Lucio Cocco, Stefano Ratti, Marco Falasca, Ramiro M. Murata, Pedro L. Rosalen, Paolo Lombardi, Massimo Libra, Saverio Candido, Giuseppe Montalto, Melchiorre Cervello, Linda S. Steelman, James A. McCubrey Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five-year survival of only 5–10%. Mutations at the TP53 gene ...
Source: Advances in Biological Regulation - June 28, 2018 Category: Biology Source Type: research
The regulation of normal and neoplastic hematopoiesis is dependent on microenvironmental cells
Publication date: Available online 27 June 2018 Source:Advances in Biological Regulation Author(s): Kenneth Kaushansky, Huichun Zhan Each day the adult human produces 4 × 1011 red blood cells, 1 × 1011 white blood cells and 1 × 1011 platelets, levels of production which can increase 10–20 fold in times of heightened demand. Hematopoiesis, or the formation of the ten different types of blood and marrow cells, is a complex process involving hematopoietic stem cells (HSCs), cytokine growth factors and cell surface adhesion molecules, and both specific and ubiquitous transcription factors. The marrow micro...
Source: Advances in Biological Regulation - June 27, 2018 Category: Biology Source Type: research
Systematic analysis of GSK-3 signaling pathways in aging of cerebral tissue
Publication date: Available online 21 June 2018 Source:Advances in Biological Regulation Author(s): D. Drulis-Fajdasz, D. Rakus, J.R. Wiśniewski, J.A. McCubrey, A. Gizak Glycogen synthase kinase-3 (GSK-3) is a constitutively active kinase, involved in regulation of multiple physiological processes. In brain, changes in GSK-3 signaling are related to neurodegenerative issues, including Alzheimer's disease. Due to the wide range of GSK-3 cellular targets, a therapeutic use of the enzyme inhibitors entails significant risk of side effects. Thus, altering the ratio of specific pool of GSK-3 or specific substrates inste...
Source: Advances in Biological Regulation - June 21, 2018 Category: Biology Source Type: research
Roles of p53, NF- κB and the androgen receptor in controlling NGAL expression in prostate cancer cell lines
Publication date: Available online 18 May 2018 Source:Advances in Biological Regulation Author(s): William H. Chappell, Saverio Candido, Stephen L. Abrams, Suzanne Russo, Roger Ove, Alberto M. Martelli, Lucio Cocco, Giulia Ramazzotti, Melchiorre Cervello, Giuseppe Montalto, Linda S. Steelman, Xiaohong Leng, Ralph B. Arlinghaus, Massimo Libra, James A. McCubrey Neutrophil gelatinase-associated lipocalin (NGAL a.k.a lipocalin 2, lnc2) is a secreted protein which can form a complex with matrix metalloproteinase-9 (MMP9). This MMP9/NGAL complex has been associated with metastasis. MMP9 and NGAL are detected in...
Source: Advances in Biological Regulation - May 18, 2018 Category: Biology Source Type: research
Nuclear organization mediates cancer-compromised genetic and epigenetic control
Publication date: Available online 9 May 2018 Source:Advances in Biological Regulation Author(s): Sayyed K. Zaidi, Andrew Fritz, Kirsten Tracy, Jonathan Gordon, Coralee Tye, Joseph Boyd, Andre Van Wijnen, Jeffrey Nickerson, Anthony Imbalzano, Jane Lian, Janet Stein, Gary Stein Nuclear organization is functionally linked to genetic and epigenetic regulation of gene expression for biological control and is modified in cancer. Nuclear organization supports cell growth and phenotypic properties of normal and cancer cells by facilitating physiologically responsive interactions of chromosomes, genes and regulatory ...
Source: Advances in Biological Regulation - May 14, 2018 Category: Biology Source Type: research
