Interaction of the Wnt/β-catenin and RAS-ERK pathways involving co-stabilization of both β-catenin and RAS plays important roles in the colorectal tumorigenesis
Publication date: May 2018Source: Advances in Biological Regulation, Volume 68Author(s): Sang-Kyu Lee, Jeong-Ha Hwang, Kang-Yell ChoiAbstractCancer development is usually driven by multiple genetic and molecular alterations rather than by a single defect. In the human colorectal cancer (CRC), series of mutations of genes are involved in the different stages of tumorigenesis. For example, adenomatous polyposis coli (APC) and KRAS mutations have been known to play roles in the initiation and progression of the tumorigenesis, respectively. However, many studies indicate that mutations of these two genes, which play roles in t...
Source: Advances in Biological Regulation - July 11, 2018 Category: Biology Source Type: research
Disrupting the ‘Warburg effect’ re-routes cancer cells to OXPHOS offering a vulnerability point via ‘ferroptosis’-induced cell death
Publication date: May 2018Source: Advances in Biological Regulation, Volume 68Author(s): Maša Ždralević, Milica Vučetić, Boutaina Daher, Ibtissam Marchiq, Scott K. Parks, Jacques PouysségurAbstractThe evolution of life from extreme hypoxic environments to an oxygen-rich atmosphere has progressively selected for successful metabolic, enzymatic and bioenergetic networks through which a myriad of organisms survive the most extreme environmental conditions. From the two lethal environments anoxia/high O2, cells have developed survival strategies through expression of the transcriptional factors ATF4, HIF1 and NRF2. Cance...
Source: Advances in Biological Regulation - July 11, 2018 Category: Biology Source Type: research
Nuclear organization mediates cancer-compromised genetic and epigenetic control
Publication date: Available online 9 May 2018Source: Advances in Biological RegulationAuthor(s): Sayyed K. Zaidi, Andrew J. Fritz, Kirsten M. Tracy, Jonathan A. Gordon, Coralee E. Tye, Joseph Boyd, Andre J. Van Wijnen, Jeffrey A. Nickerson, Antony N. Imbalzano, Jane B. Lian, Janet L. Stein, Gary S. SteinAbstractNuclear organization is functionally linked to genetic and epigenetic regulation of gene expression for biological control and is modified in cancer. Nuclear organization supports cell growth and phenotypic properties of normal and cancer cells by facilitating physiologically responsive interactions of chromosomes, ...
Source: Advances in Biological Regulation - July 11, 2018 Category: Biology Source Type: research
Roles of p53, NF-κB and the androgen receptor in controlling NGAL expression in prostate cancer cell lines
Publication date: Available online 18 May 2018Source: Advances in Biological RegulationAuthor(s): William H. Chappell, Saverio Candido, Stephen L. Abrams, Suzanne Russo, Roger Ove, Alberto M. Martelli, Lucio Cocco, Giulia Ramazzotti, Melchiorre Cervello, Giuseppe Montalto, Linda S. Steelman, Xiaohong Leng, Ralph B. Arlinghaus, Massimo Libra, James A. McCubreyAbstractNeutrophil gelatinase-associated lipocalin (NGAL a.k.a lipocalin 2, lnc2) is a secreted protein which can form a complex with matrix metalloproteinase-9 (MMP9). This MMP9/NGAL complex has been associated with metastasis. MMP9 and NGAL are detected in the urine ...
Source: Advances in Biological Regulation - July 11, 2018 Category: Biology Source Type: research
Systematic analysis of GSK-3 signaling pathways in aging of cerebral tissue
Publication date: Available online 21 June 2018Source: Advances in Biological RegulationAuthor(s): D. Drulis-Fajdasz, D. Rakus, J.R. Wiśniewski, J.A. McCubrey, A. GizakAbstractGlycogen synthase kinase-3 (GSK-3) is a constitutively active kinase, involved in regulation of multiple physiological processes. In brain, changes in GSK-3 signaling are related to neurodegenerative issues, including Alzheimer's disease. Due to the wide range of GSK-3 cellular targets, a therapeutic use of the enzyme inhibitors entails significant risk of side effects. Thus, altering the ratio of specific pool of GSK-3 or specific substrates instea...
Source: Advances in Biological Regulation - July 11, 2018 Category: Biology Source Type: research
The regulation of normal and neoplastic hematopoiesis is dependent on microenvironmental cells
Publication date: Available online 27 June 2018Source: Advances in Biological RegulationAuthor(s): Kenneth Kaushansky, Huichun ZhanAbstractEach day the adult human produces 4 × 1011 red blood cells, 1 × 1011 white blood cells and 1 × 1011 platelets, levels of production which can increase 10–20 fold in times of heightened demand. Hematopoiesis, or the formation of the ten different types of blood and marrow cells, is a complex process involving hematopoietic stem cells (HSCs), cytokine growth factors and cell surface adhesion molecules, and both specific and ubiquitous transcription factors. The marrow mic...
Source: Advances in Biological Regulation - July 11, 2018 Category: Biology Source Type: research
Introduction of WT-TP53 into pancreatic cancer cells alters sensitivity to chemotherapeutic drugs, targeted therapeutics and nutraceuticals
Publication date: Available online 28 June 2018Source: Advances in Biological RegulationAuthor(s): Stephen L. Abrams, Kvin Lertpiriyapong, Li V. Yang, Alberto M. Martelli, Lucio Cocco, Stefano Ratti, Marco Falasca, Ramiro M. Murata, Pedro L. Rosalen, Paolo Lombardi, Massimo Libra, Saverio Candido, Giuseppe Montalto, Melchiorre Cervello, Linda S. Steelman, James A. McCubreyAbstractPancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five-year survival of only 5–10%. Mutations at the TP53 gene are readily ...
Source: Advances in Biological Regulation - July 11, 2018 Category: Biology Source Type: research
Where do substrates of diacylglycerol kinases come from? Diacylglycerol kinases utilize diacylglycerol species supplied from phosphatidylinositol turnover-independent pathways
Publication date: January 2018Source: Advances in Biological Regulation, Volume 67Author(s): Fumio Sakane, Satoru Mizuno, Daisuke Takahashi, Hiromichi SakaiAbstractDiacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to produce phosphatidic acid (PA). Mammalian DGK comprises ten isozymes (α–κ) and regulates a wide variety of physiological and pathological events, such as cancer, type II diabetes, neuronal disorders and immune responses. DG and PA consist of various molecular species that have different acyl chains at the sn-1 and sn-2 positions, and consequently, mammalian cells contain at least 50 structural...
Source: Advances in Biological Regulation - July 5, 2018 Category: Biology Source Type: research
Review of four major distinct types of human phospholipase A2
Publication date: January 2018Source: Advances in Biological Regulation, Volume 67Author(s): Alexis M. Vasquez, Varnavas D. Mouchlis, Edward A. DennisAbstractThe phospholipase A2 superfamily of enzymes plays a significant role in the development and progression of numerous inflammatory diseases. Through their catalytic action on membrane phospholipids, phospholipases are the upstream regulators of the eicosanoid pathway releasing free fatty acids for cyclooxygenases, lipoxygenases, and cytochrome P450 enzymes which produce various well-known inflammatory mediators including leukotrienes, thromboxanes and prostaglandins. El...
Source: Advances in Biological Regulation - July 5, 2018 Category: Biology Source Type: research
Effects of berberine, curcumin, resveratrol alone and in combination with chemotherapeutic drugs and signal transduction inhibitors on cancer cells—Power of nutraceuticals
Publication date: January 2018Source: Advances in Biological Regulation, Volume 67Author(s): James A. McCubrey, Stephen L. Abrams, Kvin Lertpiriyapong, Lucio Cocco, Stefano Ratti, Alberto M. Martelli, Saverio Candido, Massimo Libra, Ramiro M. Murata, Pedro L. Rosalen, Paolo Lombardi, Giuseppe Montalto, Melchiorre Cervello, Agnieszka Gizak, Dariusz Rakus, Linda S. SteelmanAbstractOver the past fifty years, society has become aware of the importance of a healthy diet in terms of human fitness and longevity. More recently, the concept of the beneficial effects of certain components of our diet and other compounds, that are co...
Source: Advances in Biological Regulation - July 5, 2018 Category: Biology Source Type: research
PLCγ1: Potential arbitrator of cancer progression
Publication date: January 2018Source: Advances in Biological Regulation, Volume 67Author(s): Hyun-Jun Jang, Pann-Ghill Suh, Yu Jin Lee, Kyeong Jin Shin, Lucio Cocco, Young Chan ChaeAbstractPhospholipase C (PLC) is an essential mediator of cellular signaling. PLC regulates multiple cellular processes by generating bioactive molecules such as inositol-1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These products propagate and regulate cellular signaling via calcium (Ca2+) mobilization and activation of protein kinase C (PKC), other kinases, and ion channels. PLCγ1, one of the primary subtypes of PLC, is directly activat...
Source: Advances in Biological Regulation - July 5, 2018 Category: Biology Source Type: research
Signaling by cell surface death receptors: Alterations in head and neck cancer
Publication date: January 2018Source: Advances in Biological Regulation, Volume 67Author(s): Brandon C. Leonard, Daniel E. JohnsonAbstractCell surface death receptors are members of the tumor necrosis factor receptor (TNFR) superfamily and mediate signals leading to the induction of apoptosis or necroptosis, as well as NF-κB-mediated cell survival. These biochemical processes play key roles in cell growth, development, tissue homeostasis, and immune responses. The downstream signaling complexes activated by different death receptors can differ significantly and are subject to multiple, distinct regulatory mechanisms. Dysr...
Source: Advances in Biological Regulation - July 5, 2018 Category: Biology Source Type: research
Advances in Biological Regulation
Publication date: January 2018Source: Advances in Biological Regulation, Volume 67Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - July 5, 2018 Category: Biology Source Type: research
Acknowledgements
Publication date: January 2018Source: Advances in Biological Regulation, Volume 67Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - July 5, 2018 Category: Biology Source Type: research
Foreword
Publication date: January 2018Source: Advances in Biological Regulation, Volume 67Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - July 5, 2018 Category: Biology Source Type: research
